2008
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Geller DS, Zhang J, Wisgerhof MV, Shackleton C, Kashgarian M, Lifton RP. A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 3117-3123. PMID: 18505761, PMCID: PMC2515083, DOI: 10.1210/jc.2008-0594.Peer-Reviewed Original ResearchConceptsGlucocorticoid-remediable aldosteronismAdrenal fasciculataAdministration of dexamethasoneAdrenal steroid productionAdrenal steroid biosynthesisNew familial formAge 7 yrSecondary hypertensionBilateral adrenalectomyMost patientsPrimary aldosteronismAdrenal weightClinical syndromeAdrenal glandCortisol secretionLeading causeAldosteronismHypertensionMedical treatmentAldosterone synthaseSteroid productionAutosomal dominant formCellular hypertrophyCortical compartmentFamilial forms
1970
A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency
Kotchen T, Knight E, Kashgarian M, Mulrow P. A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency. Nephron 1970, 7: 317-330. PMID: 4316656, DOI: 10.1159/000179832.Peer-Reviewed Original ResearchConceptsRenin activitySevere chronic renal insufficiencyChronic dialysis programRenin substrate levelsChronic renal insufficiencyPlasma renin activityMean arterial pressureRenin-angiotensin systemNormal plasma levelsMalignant hypertensionRenal insufficiencyRenin levelsOnly patientsArterial pressureBlood pressureUremic patientsDialysis programPlasma levelsUremic plasmaAutopsy specimensJG cellsBowie stainPatientsReninDialysis
1967
Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*
Hayslett J, Kashgarian M, Epstein F. Changes in Proximal and Distal Tubular Reabsorption Produced by Rapid Expansion of Extracellular Fluid*. Journal Of Clinical Investigation 1967, 46: 1254-1263. PMID: 6027087, PMCID: PMC297124, DOI: 10.1172/jci105618.Peer-Reviewed Original ResearchConceptsTubular reabsorptionTubular diameterDistal tubular reabsorptionGlomerular filtration rateProximal tubular reabsorptionAdministration of aldosteroneLoop of HenleAcute infusionFiltration rateRenal contentSaline infusionGlomerular filtrationSegments of tubulesIsotonic salineProximal tubulesExcretion of saltTubular flowReabsorptionExtracellular fluidInfusionTubulesInterstitial volumeRatsTransit timeAldosterone