2014
Outcomes in patients undergoing nephrectomy for renal cancer on chronic anticoagulation therapy
Sfakianos J, Hakimi A, Kim P, Zabor E, Mano R, Bernstein M, Karellas M, Russo P. Outcomes in patients undergoing nephrectomy for renal cancer on chronic anticoagulation therapy. European Journal Of Surgical Oncology 2014, 40: 1700-1705. PMID: 24813810, PMCID: PMC4208948, DOI: 10.1016/j.ejso.2014.04.010.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnticoagulantsAspirinBlood TransfusionFemaleFibrinolytic AgentsHumansIncidenceIntraoperative ComplicationsKidney NeoplasmsLength of StayMaleMiddle AgedNeoplasm StagingNephrectomyPlatelet Aggregation InhibitorsPostoperative ComplicationsRetrospective StudiesRisk FactorsSeverity of Illness IndexTreatment OutcomeUnited StatesConceptsOverall complication rateComplication rateChronic anticoagulationRenal tumorsChronic anticoagulation therapyLength of stayLogistic regression modelsACT patientsAspirin patientsChronic aspirinHigher transfusionAnticoagulation therapyASA scoreAspirin useTransfusion rateAnticoagulation groupSurgical resectionMedian lengthOpen surgeryClinical differencesRenal surgeryGrade 3Renal cancerRetrospective analysisAnticoagulation
2013
Increased Incidence of Pathologically Nonorgan Confined Prostate Cancer in African-American Men Eligible for Active Surveillance
Ha Y, Salmasi A, Karellas M, Singer E, Kim J, Han M, Partin A, Kim W, Lee D, Kim I. Increased Incidence of Pathologically Nonorgan Confined Prostate Cancer in African-American Men Eligible for Active Surveillance. Urology 2013, 81: 831-836. PMID: 23465143, PMCID: PMC3978180, DOI: 10.1016/j.urology.2012.12.046.Peer-Reviewed Original ResearchConceptsNational Comprehensive Cancer NetworkAA menRadical prostatectomyActive surveillanceProstate cancerNCCN criteriaBiopsy coresAS criteriaAS inclusion criteriaFinal surgical pathologyComprehensive Cancer NetworkPositive biopsy coresDatabase of menWorse clinicopathological featuresAfrican American menPathological upstagingAdvanced diseaseIndependent predictorsPathologic characteristicsClinicopathological featuresPreoperative PSAClinicopathologic findingsWA patientsInclusion criteriaPositive cores
2012
Defining the impact of vascular risk factors on erectile function recovery after radical prostatectomy
Teloken P, Nelson C, Karellas M, Stasi J, Eastham J, Scardino P, Mulhall J. Defining the impact of vascular risk factors on erectile function recovery after radical prostatectomy. BJU International 2012, 111: 653-657. PMID: 22758405, DOI: 10.1111/j.1464-410x.2012.11321.x.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAnalysis of VarianceAustraliaDatabases, FactualDiabetes MellitusErectile DysfunctionFollow-Up StudiesHumansHypercholesterolemiaHypertensionMaleMiddle AgedMultivariate AnalysisPenile ErectionProspective StudiesProstatectomyProstatic NeoplasmsRecovery of FunctionRegression AnalysisRisk FactorsSmokingTreatment OutcomeVascular DiseasesConceptsVascular risk factorsErectile function recoveryPreoperative erectile functionRadical prostatectomyFunction recoveryErectile functionRisk factorsPatient factorsSurgical techniquePresence of VRFNerve-sparing statusPostoperative erectile functionNew treatment strategiesProspective databaseEF recoverySTUDY ADDDiabetes mellitusMultivariable analysisCigarette smokingErectile dysfunctionPatient counsellingUnivariate analysisProstate cancerTreatment strategiesPreoperative information
2010
Partial nephrectomy for selected renal cortical tumours of ≥7 cm
Karellas M, O’Brien M, Jang T, Bernstein M, Russo P. Partial nephrectomy for selected renal cortical tumours of ≥7 cm. BJU International 2010, 106: 1484-1487. PMID: 20518765, PMCID: PMC4319322, DOI: 10.1111/j.1464-410x.2010.09405.x.Peer-Reviewed Original ResearchConceptsRenal cortical tumorsPartial nephrectomyCortical tumorsRenal unitsLarge tumorsPre-existing renal insufficiencyUse of PNConventional clear cell carcinomaAccepted surgical approachMedian tumor sizeGlomerular filtration rateInstitutional review board approvalClear cell carcinomaEffective tumor controlReview board approvalRenal insufficiencySolitary kidneyMetastatic diseaseMedian ageAppropriate tumorSurgical databaseTumor sizeCell carcinomaSurgical approachTumor controlEditorial Comment
Karellas M. Editorial Comment. Journal Of Urology 2010, 183: 137. PMID: 19913247, DOI: 10.1016/j.juro.2009.08.198.Peer-Reviewed Original Research
2008
Advanced‐stage renal cell carcinoma treated by radical nephrectomy and adjacent organ or structure resection
Karellas M, Jang T, Kagiwada M, Kinnaman M, Jarnagin W, Russo P. Advanced‐stage renal cell carcinoma treated by radical nephrectomy and adjacent organ or structure resection. BJU International 2008, 103: 160-164. PMID: 18782305, PMCID: PMC2769168, DOI: 10.1111/j.1464-410x.2008.08025.x.Peer-Reviewed Original ResearchConceptsRenal cell carcinomaRadical nephrectomyAdjacent organsCell carcinomaAdvanced stage renal cell carcinomaAdvanced renal cell carcinomaConventional clear cell carcinomaAdjuvant clinical trialsEvidence of diseaseInstitutional review board approvalPositive surgical marginsSurgical margin statusClear cell carcinomaPathological stage T3Review board approvalPT4 stageMetastatic diseaseMost patientsSurgical resectionSystemic agentsMargin statusSurgical managementSurgical marginsStage T3Clinical trialsSurvival rates after resection for localized kidney cancer: 1989 to 2004
Russo P, Jang T, Pettus J, Huang W, Eggener S, O'Brien M, Karellas M, Karanikolas N, Kagiwada M. Survival rates after resection for localized kidney cancer: 1989 to 2004. Cancer 2008, 113: 84-96. PMID: 18470927, PMCID: PMC3985136, DOI: 10.1002/cncr.23520.Peer-Reviewed Original ResearchConceptsProgression-free survivalNumber of nephrectomiesProportion of patientsOverall patient survivalDisease progressionKidney cancerOverall survivalLocal recurrenceDistant metastasisPatient survivalTumor sizeRenal tumorsFive-year progression-free survivalMemorial Sloan-Kettering Cancer CenterMultivariate Cox regression analysisConcomitant lymph node dissectionSelect renal tumorsSurgery-related characteristicsLymph node dissectionYear of surgeryKaplan-Meier methodCox regression analysisCurrent treatment paradigmsSmall renal tumorsTumor size categories
2007
ITGCN of the Testis, Contralateral Testicular Biopsy and Bilateral Testicular Cancer
Karellas M, Damjanov I, Holzbeierlein J. ITGCN of the Testis, Contralateral Testicular Biopsy and Bilateral Testicular Cancer. Urologic Clinics Of North America 2007, 34: 119-125. PMID: 17484917, DOI: 10.1016/j.ucl.2007.02.015.Peer-Reviewed Original ResearchConceptsContralateral testicular biopsyTesticular tumorsTesticular biopsyIntratubular germ cell neoplasiaTesticular germ cell tumorsBilateral testicular cancerBilateral testicular tumorsGerm cell tumorsGerm cell neoplasiaNoninvasive precursor lesionsTreatment optionsTesticular cancerCell tumorsPrecursor lesionsCell neoplasiaMalignant transformationDiagnostic strategiesTumorsMolecular changesBiopsyNeoplasiaSkakkebaekLesionsCancerIncidence
2006
Medical management of common urinary calculi.
Pietrow P, Karellas M. Medical management of common urinary calculi. American Family Physician 2006, 74: 86-94. PMID: 16848382.Peer-Reviewed Original ResearchConceptsMost patientsRecurrent calculiAggressive fluid intakeIntake of saltMedical managementFluid recommendationsPharmacologic interventionsFluid intakeUrine collectionSerum studiesCommon conditionGenetic predispositionInfectious calculiPatientsU.S. menMetabolic investigationsCommon urinary calculiUrinary calculiIntakeStone inhibitorsInhibitorsHypercalciuriaThiazidesDiureticsMedicationsEvaluation of Ureterointestinal Anastomosis: Wallace vs Bricker
Evangelidis A, Lee E, Karellas M, Thrasher J, Holzbeierlein J. Evaluation of Ureterointestinal Anastomosis: Wallace vs Bricker. Journal Of Urology 2006, 175: 1755-1758. PMID: 16600750, DOI: 10.1016/s0022-5347(05)01020-7.Peer-Reviewed Original ResearchConceptsStricture rateUreterointestinal anastomosisOperating room timeBricker anastomosisWallace anastomosisRadiation therapyRoom timeDays of followupNeoadjuvant radiation therapyNumber of patientsType of diversionSignificant differencesBricker's methodAdjuvant radiationAdjuvant therapyComplication rateCystectomy databaseRetrospective reviewStricture formationBricker groupPatientsAnastomosisWallace groupTherapyStricture
2005
ACUTE RENAL FAILURE IN A MONOZYGOTIC TWIN PRESENTING WITH CLOACAL EXSTROPHY
KARELLAS M, GATTI J, MURPHY J. ACUTE RENAL FAILURE IN A MONOZYGOTIC TWIN PRESENTING WITH CLOACAL EXSTROPHY. Journal Of Urology 2005, 173: 230-231. PMID: 15592082, DOI: 10.1097/01.ju.0000148422.02693.57.Peer-Reviewed Original Research