2020
Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development?
Wu R, Nie J, Abraham P, Halligan T, Gabrick K, Peck CJ, Sawh-Martinez R, Steinbacher DM, Alperovich M, McPartland J, Persing JA. Neurologic Characterization of Craniosynostosis: Can Direct Brain Recordings Predict Language Development? Journal Of Craniofacial Surgery 2020, 32: 78-82. PMID: 32941205, DOI: 10.1097/scs.0000000000007004.Peer-Reviewed Original ResearchConceptsNeural responsesLanguage deficitsLanguage developmentERP assessmentMetopic patientsMismatch negativity waveLarger negative amplitudesLong-term cognitionLanguage achievementCognitive outcomesMMNBrain recordingsInfant developmentBayley ScalesNegative amplitudeBSID scoresEEG testingBSIDDeficitsElectroencephalogramNeurocognitionCognitionSpeechStimuliYears of ageRisk of peri-operative complications in children receiving preoperative steroids
Mets EJ, Chouairi F, Mirza H, Allam O, Park KE, Junn A, Alperovich M. Risk of peri-operative complications in children receiving preoperative steroids. Pediatric Surgery International 2020, 36: 1345-1352. PMID: 32918623, DOI: 10.1007/s00383-020-04742-9.Peer-Reviewed Original ResearchConceptsAdverse eventsPediatric patientsSteroid usePreoperative steroidsNational Surgical Quality Improvement Project Pediatric databaseThirty-day adverse eventsPropensity scorePostoperative adverse eventsPeri-operative complicationsPediatric surgery patientsSimilar larger studiesMore comorbiditiesPerioperative impactHospital stayPerioperative complicationsAdult patientsPatient demographicsSteroid treatmentSurgery patientsSurgical variablesWound dehiscenceSurgical outcomesPediatric databasePatientsLarger studySpring-Assisted Strip Craniectomy Versus Cranial Vault Remodeling: Long-Term Psychological, Behavioral, and Executive Function Outcomes.
Chandler L, Allam O, Park KE, Smetona J, Gabrick KS, Wu RT, Morgan C, Park SE, Chapman LA, Couture DE, David LR, Runyan CM, Persing JA, Alperovich M. Spring-Assisted Strip Craniectomy Versus Cranial Vault Remodeling: Long-Term Psychological, Behavioral, and Executive Function Outcomes. Journal Of Craniofacial Surgery 2020, 31: 2101-2105. PMID: 32890160, DOI: 10.1097/scs.0000000000006806.Peer-Reviewed Original ResearchConceptsExecutive function outcomesExecutive functioning skillsBehavior Rating InventoryBehavior Assessment SystemSocial withdrawal symptomsExecutive functionRating InventoryBASC-2Term PsychologicalNon-syndromic sagittal synostosisCohen's dSecond editionSAS groupChildrenFunction outcomesWithdrawal symptomsPsychologicalAssessment systemBehavioralSkillsParentsCaregiversInventoryExecutivesWhat Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis?
Lu X, Forte AJ, Wilson AT, Park KE, Allam O, Mozaffari MA, Alperovich M, Steinbacher DM, Alonso N, Persing JA. What Is the Difference in Cranial Base Morphology in Isolated and Syndromic Bicoronal Synostosis? Plastic & Reconstructive Surgery 2020, 146: 599-610. PMID: 32842109, DOI: 10.1097/prs.0000000000007068.Peer-Reviewed Original ResearchClassification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Classification of Subtypes of Crouzon Syndrome Based on the Type of Vault Suture Synostosis. Journal Of Craniofacial Surgery 2020, 31: 678-684. PMID: 32068731, DOI: 10.1097/scs.0000000000006173.Peer-Reviewed Original ResearchConceptsClass IIICrouzon syndromeClass IClass IISuture involvementSuture synostosisSimilar craniofacial characteristicsComputed tomography scanClassification of subtypesSurgical interventionMorphology of patientsAnatomic deformityTomography scanSurgical techniqueCT scanDifferent subtypesSagittal synostosisSyndromeClass IVPremature closureCraniofacial characteristicsSevere craniofacial malformationsCranial base lengthSynostosisDifferent pathologiesSMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis.
Wu RT, Timberlake AT, Abraham PF, Gabrick KS, Lu X, Peck CJ, Sawh-Martinez RF, Steinbacher DM, Alperovich MA, Persing JA. SMAD6 Genotype Predicts Neurodevelopment in Nonsyndromic Craniosynostosis. Plastic & Reconstructive Surgery 2020, 145: 117e-125e. PMID: 31592950, DOI: 10.1097/prs.0000000000006319.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild BehaviorChild DevelopmentChild, PreschoolCraniosynostosesCraniotomyDevelopmental DisabilitiesDouble-Blind MethodFemaleFollow-Up StudiesHumansInfantIntelligence TestsLoss of Function MutationMalePlastic Surgery ProceduresProspective StudiesSkullSmad6 ProteinTreatment Outcome
2019
Veau III and Veau IV Cleft Palate: Do Peri-Operative Complications Differ?
Chouairi F, Mets EJ, Gabrick KS, Alperovich M. Veau III and Veau IV Cleft Palate: Do Peri-Operative Complications Differ? Journal Of Craniofacial Surgery 2019, 30: 2372-2374. PMID: 31584550, DOI: 10.1097/scs.0000000000005918.Peer-Reviewed Original ResearchCleft lip repair: are outcomes between unilateral and bilateral clefts comparable?
Chouairi F, Mets EJ, Torabi SJ, Alperovich M. Cleft lip repair: are outcomes between unilateral and bilateral clefts comparable? Journal Of Plastic Surgery And Hand Surgery 2019, 54: 29-32. PMID: 31524555, DOI: 10.1080/2000656x.2019.1661848.Peer-Reviewed Original ResearchMeSH KeywordsAsthmaCardiovascular Surgical ProceduresCase-Control StudiesCentral Nervous SystemCleft LipComorbidityDatabases, FactualDevelopmental DisabilitiesFemaleGastrointestinal DiseasesHumansInfantMaleNutritional SupportPatient ReadmissionReoperationRespiration, ArtificialTracheostomyUnited StatesConceptsPeri-operative outcomesCleft lip repairMore comorbiditiesBilateral cleftsCleft lipNational Surgical Quality Improvement Program Pediatric databaseLip repairStructural central nervous system abnormalitiesCentral nervous system abnormalitiesPrimary cleft lip repairUnilateral cleft lip patientsBilateral cleft patientsPrevious cardiac surgeryPost-operative outcomesPrimary cleft lipNervous system abnormalitiesBilateral cleft lipCleft lip patientsCleft populationVentilator dependencePatient demographicsCardiac surgeryNutritional supportPropensity matchingOperative courseAirway Analysis in Apert Syndrome.
Forte AJ, Lu X, Hashim PW, Steinbacher DM, Alperovich M, Persing JA, Alonso N. Airway Analysis in Apert Syndrome. Plastic & Reconstructive Surgery 2019, 144: 704-709. PMID: 31461034, DOI: 10.1097/prs.0000000000005937.Peer-Reviewed Original ResearchConceptsPosterior nasal spineApert syndromeNasal spineTomographic scanPharyngeal airway volumeRespiratory insufficiencyAirway compromiseAirway volumeAirway spaceRespiratory impairmentClinical managementAirway analysisPosterior airwayNasal cavityDisease comorbiditiesPatientsSyndromeSkull baseNasal measurementsSpine distanceStatistical significanceMidfacial deformitiesSpineAirwayPharyngeal regionPredictors of Adverse Events Following Cleft Palate Repair.
Mets EJ, Chouairi F, Torabi SJ, Alperovich M. Predictors of Adverse Events Following Cleft Palate Repair. Journal Of Craniofacial Surgery 2019, 30: 1414-1418. PMID: 31299734, DOI: 10.1097/scs.0000000000005542.Peer-Reviewed Original ResearchConceptsCleft palate repairPerioperative blood transfusionBronchopulmonary dysplasia/chronic lung diseaseAdverse eventsChronic lung diseaseBlood transfusionPalate repairRisk factorsCerebral palsyLung diseaseNational Surgical Quality Improvement Project Pediatric databasePrimary cleft palate repairWound dehiscence rateSurgical risk factorsThirty-day readmissionIntraoperative adverse eventsPost-surgical complicationsSystemic risk factorsCleft palate surgeryYears of ageLife-threatening risksReoperation rateProlonged lengthPulmonary diseaseRisk stratificationAssociation of Regional Cranial Base Deformity and Ultimate Structure in Crouzon Syndrome.
Lu X, Jorge Forte A, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Association of Regional Cranial Base Deformity and Ultimate Structure in Crouzon Syndrome. Plastic & Reconstructive Surgery 2019, 143: 1233e-1243e. PMID: 31136487, DOI: 10.1097/prs.0000000000005643.Peer-Reviewed Original ResearchWhat is the Functional Difference Between Sagittal With Metopic and Isolated Sagittal Craniosynotosis?
Cabrejo R, Lacadie C, Chuang C, Yang J, Sun A, Brooks E, Beckett J, Eilbott J, Gabrick K, Steinbacher D, Alperovich M, Pelphrey K, Ventola P, Constable T, Persing JA. What is the Functional Difference Between Sagittal With Metopic and Isolated Sagittal Craniosynotosis? Journal Of Craniofacial Surgery 2019, 30: 968-973. PMID: 30882572, DOI: 10.1097/scs.0000000000005288.Peer-Reviewed Original ResearchConceptsDiffusion tensor imagingFunctional magnetic resonance imagingISC groupInfant patientsFunctional brain connectivityMagnetic resonance imagingResting-state functional connectivity MRI dataDTI dataWhite matter microstructureCerebrospinal fluidFMRIB Software LibraryResonance imagingSagittal synostosisSagittal craniosynostosisMetopic synostosisPatientsTensor imagingBrain connectivityMetopic craniosynostosisSMC groupFMRI imagingSignificant differencesSynostosisSagittalMRI dataNational 30-Day Outcomes for Posterior Cranial Vault Distraction
Chouairi F, Torabi SJ, Alperovich M. National 30-Day Outcomes for Posterior Cranial Vault Distraction. Journal Of Craniofacial Surgery 2019, Publish Ahead of Print: &na;. PMID: 30807468, DOI: 10.1097/scs.0000000000005285.Peer-Reviewed Original ResearchConceptsPosterior vault distractionOperative timePediatric databaseNational Surgical Quality Improvement Program Pediatric databaseCalvarial volumeBlood transfusion volumeIncidence of strokeMajority of patientsSurgical site infectionPosterior cranial vault distractionNational pediatric databaseTransfusion requirementsTransfusion volumeOlder patientsPerioperative outcomesBlood transfusionPatient ageSite infectionPatient backgroundSafety profileSafe procedureRisk factorsInclusion criteriaPatient profilesPatientsMandibular Spatial Reorientation and Morphological Alteration of Crouzon and Apert Syndrome.
Lu X, Sawh-Martinez R, Forte AJ, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Mandibular Spatial Reorientation and Morphological Alteration of Crouzon and Apert Syndrome. Annals Of Plastic Surgery 2019, 83: 568-582. PMID: 31008788, DOI: 10.1097/sap.0000000000001811.Peer-Reviewed Original ResearchTemporal Evaluation of Craniofacial Relationships in Apert Syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Gabrick K, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Temporal Evaluation of Craniofacial Relationships in Apert Syndrome. Journal Of Craniofacial Surgery 2019, 30: 317-325. PMID: 30358751, DOI: 10.1097/scs.0000000000004836.Peer-Reviewed Original ResearchConceptsYears of ageApert syndromeNasal spineComputed tomography scanMaxillary planeAnterior nasal spineMonths of ageApert syndrome patientsPosterior nasal spineSella-nasion planeTomography scanSyndrome patientsAge subgroupsAnatomic relationshipsSyndromeFacial deformityAngulation changeFrankfort horizontal planeCranial base lengthMonthsIntracellular regulatory mechanismsCraniofacial malformationsAgeDeformityMaterialize softwareSpatial and temporal changes of midface in Apert’s syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Wilson A, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Spatial and temporal changes of midface in Apert’s syndrome. Journal Of Plastic Surgery And Hand Surgery 2019, 53: 130-137. PMID: 30782083, DOI: 10.1080/2000656x.2018.1541324.Peer-Reviewed Original Research
2018
Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Orbit, zygoma, and maxilla growth patterns in Crouzon syndrome. International Journal Of Oral And Maxillofacial Surgery 2018, 48: 309-321. PMID: 30389113, DOI: 10.1016/j.ijom.2018.10.013.Peer-Reviewed Original ResearchConceptsCrouzon syndromeCT scanAnteroposterior lengthWidth of maxillaPreoperative CT scanMonths-2 yearsMonths of agePrincipal deformityControl subjectsGlobe projectionAge subgroupsMaxillary wideningSecondary deformitiesOrbital wallAnterior protrusionSyndromeFacial malformationsMonthsDeformityAnteroposterior positionZygomatic regionCranial baseZygomaMalformationsMaterialise softwareAnterior convex lateral orbital wall: distinctive morphology in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Anterior convex lateral orbital wall: distinctive morphology in Apert syndrome. British Journal Of Oral And Maxillofacial Surgery 2018, 56: 864-869. PMID: 30337164, DOI: 10.1016/j.bjoms.2018.09.011.Peer-Reviewed Original ResearchNational Longitudinal Comparison of Patients Undergoing Surgical Management of Craniosynostosis
Wu RT, Shultz BN, Gabrick KS, Abraham PF, Cabrejo R, Persing JA, Alperovich M. National Longitudinal Comparison of Patients Undergoing Surgical Management of Craniosynostosis. Journal Of Craniofacial Surgery 2018, 29: 1755-1759. PMID: 30095569, DOI: 10.1097/scs.0000000000004775.Peer-Reviewed Original ResearchConceptsCranial vault remodelingCVR patientsLength of stayPrivate insuranceStrip craniectomyInpatient DatabaseCraniectomy patientsVault remodelingKids' Inpatient DatabaseNonsyndromic craniosynostosis patientsCraniosynostosis managementInsurancePostsurgical complicationsSurgical managementHospital chargesTreatment optionsLongitudinal comparisonHospital characteristicsSerum transfusionMedicaid patientsAccidental punctureSurgical preferenceCraniectomyPatientsMultivariate analysisNormal angulation of skull base in Apert syndrome
Lu X, Forte AJ, Sawh-Martinez R, Wu R, Cabrejo R, Steinbacher DM, Alperovich M, Alonso N, Persing JA. Normal angulation of skull base in Apert syndrome. Journal Of Cranio-Maxillofacial Surgery 2018, 46: 2042-2051. PMID: 30391086, DOI: 10.1016/j.jcms.2018.09.026.Peer-Reviewed Original ResearchConceptsAnterior cranial baseApert syndromeCranial base lengthSkull baseSevere craniofacial deformitiesPosterior cranial base lengthYears of ageMonths of ageUnoperated patientsCT scanAnterior cranial base lengthCranial base angleLate infancySyndromeAge rangeCraniofacial deformitiesCranial baseDeformityAdditive effectSkull vaultMonthsAngulationSignificant changesAgeBase length