2025
Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review
Jalilian-Khave L, Kitaneh R, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. Potential roles for vitamin D in preventing and treating impulse control disorders, behavioral addictions, and substance use disorders: A scoping review. Addiction Neuroscience 2025, 14: 100190. DOI: 10.1016/j.addicn.2024.100190.Peer-Reviewed Original ResearchImpulse control disordersSubstance use disordersControl disordersBehavioral addictionsTreating impulse control disordersVitamin DClinical studiesAddictive disordersSerotonergic circuitsExposure to vitamin DVitamin D deficiencyVitamin D levelsSymptom presenceDisordersPotential beneficial effectsJoanna Briggs InstituteD deficiencyPotential therapeutic mechanismAddictionD levelsWeb of ScienceTherapeutic mechanismQuality of studiesCochrane LibraryOvid MEDLINE
2024
The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
Sandhu M, Schonwald A, Boyko M, Jafar T, Freedman I, Woeste J, Kurup A, Funaro M, Zlotnik A, Gruenbaum S, Elsamadicy A, Reynolds R, Gruenbaum B. The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2024, 168: 105952. PMID: 39603437, DOI: 10.1016/j.neubiorev.2024.105952.Peer-Reviewed Original ResearchPost-TBI depressionTraumatic brain injurySpectrum of TBI severityBrain injuryDiagnosis of depressionNeurobehavioral symptomsTBI severitySystematic reviewDepressionMeta-analysisStatistically significant differenceMedian ageFemale patientsPooled analysisFemale sexRisk factorsSevere casesParticipantsPotential associationSignificant differenceSexSeverityRiskInjurySubjectsAssociations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review
Hsaio C, DiMeola K, Jegede O, Funaro M, Langstengel J, Yaggi H, Barry D. Associations Among Sleep, Pain, and Medications for Opioid Use Disorder: a Scoping Review. Current Addiction Reports 2024, 1-17. DOI: 10.1007/s40429-024-00606-7.Peer-Reviewed Original ResearchOpioid use disorderOUD severityUse disorderTreatment characteristicsOpioid use disorder treatment settingsTreatment of sleepDosing scheduleDisorder severityOpioidPainWeb of ScienceAssessed patientsCochrane LibraryMeasures of sleepMOUD treatmentCurrent evidenceMOUDSleepSleep disturbanceProvider preferencesPatientsStudy examined sleepDisordersTreatment settingsMedicationLong-Term Use of Muscle Relaxant Medications for Chronic Pain
Oldfield B, Gleeson B, Morford K, Adams Z, Funaro M, Becker W, Merlin J. Long-Term Use of Muscle Relaxant Medications for Chronic Pain. JAMA Network Open 2024, 7: e2434835. PMID: 39298168, PMCID: PMC11413720, DOI: 10.1001/jamanetworkopen.2024.34835.Peer-Reviewed Original ResearchConceptsLow back painBack painSkeletal muscle relaxantsChronic painRandomized clinical trialsNeck painCohort studyEfficacy of long-term useLong-term useSystematically searched Ovid MEDLINEMuscle relaxant medicationsModerate risk of biasOpioid prescribing guidelinesRisk of biasQuality of cohort studiesWeb of SciencePainful crampsRelaxant medicationsChronic pain syndromesPainful spasmsOvid MEDLINEPrescribing guidelinesSystematic reviewIncreased prescriptionModerate riskSelf-Change from Alcohol Problems among Racially and Ethnically Minoritized Adults: A Systematic Review
Haeny A, Schick M, Crouch M, Bautista T, Chowdhary A, McKenley C, Funaro M. Self-Change from Alcohol Problems among Racially and Ethnically Minoritized Adults: A Systematic Review. Current Addiction Reports 2024, 11: 818-837. DOI: 10.1007/s40429-024-00591-x.Peer-Reviewed Original ResearchSelf-changeAlcohol problemsProcess of self-changeREM groupRelevant constructsMultiracial groupsRacial identityFormal treatmentNative groupsNative HawaiiansLatin groupAlaska Native communitiesAlaska Native groupsREMPacific IslandersAlcoholNative communitiesAdultsSystematic reviewSystematic literature reviewHealing strategiesThe Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review
Jegede O, De Aquino J, Hsaio C, Caldwell E, Funaro M, Petrakis I, Muvvala S. The Impact of High-Potency Synthetic Opioids on Pharmacotherapies for Opioid Use Disorder: A Scoping Review. Journal Of Addiction Medicine 2024, 18: 499-510. PMID: 39356620, PMCID: PMC11449257, DOI: 10.1097/adm.0000000000001356.Peer-Reviewed Original ResearchNonmedical opioid useOpioid use disorderOpioid useWithdrawal symptomsTreatment outcomesSymptoms prior to treatmentUse disorderRisk of precipitated withdrawalLow-dose buprenorphineSynthetic opioidsPotency synthetic opioidsConclusions Current evidencePrecipitated withdrawalRisk of overdoseDosing strategiesPharmacological interactionsClinical significanceDecreased riskWeb of ScienceOpioidInclusion criteriaCurrent evidenceClinical implicationsMOUDPainThe Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews
Kitaneh R, Jalilian-Khave L, Ysrayl B, Borelli A, Funaro M, Potenza M, Angarita G. The Relationship Between Vitamin D and the Development and Treatment of Attention-Deficit Hyperactivity Disorder: An Overview of Systematic Reviews. Current Behavioral Neuroscience Reports 2024, 11: 164-181. DOI: 10.1007/s40473-024-00278-7.Peer-Reviewed Original ResearchAttention-deficit/hyperactivity disorderAttention-deficit/hyperactivity disorder symptomsTreatment of attention-deficit hyperactivity disorderSeverity of ADHD symptomsAttention-deficit hyperactivity disorderManagement of attention-deficit/hyperactivity disorderOutcomes of attention-deficit/hyperactivity disorderOverview of systematic reviewsADHD symptomsSerum vitamin D levelsHyperactivity disorderInclusion criteriaMeta-analysesVitamin D levelsBrain regionsMaternal serum vitamin D levelsPrenatal vitamin D levelsAssociated with improvementsNeurotransmitter regulationRisk of offspringVitamin D supplementationD levelsWell-powered randomized clinical trialsSystematic literature searchSummaryThe literatureA review of the kappa opioid receptor system in opioid use
Cayir S, Zhornitsky S, Barzegary A, Sotomayor-Carreño E, Sarfo-Ansah W, Funaro M, Matuskey D, Angarita G. A review of the kappa opioid receptor system in opioid use. Neuroscience & Biobehavioral Reviews 2024, 162: 105713. PMID: 38733895, DOI: 10.1016/j.neubiorev.2024.105713.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsKappa opioid receptor systemKappa-opioid receptorsOUD subjectsKappa-opioid receptor expressionOpioid withdrawal symptomsWithdrawal symptomsDynorphin levelsPeripheral blood lymphocytesOpioid useDrug-seeking/taking behaviorAnti-reward systemsKappa-opioid receptor antagonistClinical studiesCerebrospinal fluidOpioid receptor systemKOR/dynorphin systemDisorder subjectsOpioid receptorsOpioid intoxicationBlood lymphocytesReceptor systemOpioidWeb of ScienceClinical roleDynorphinPrehospital use of point-of-care tests by community health workers: a scoping review
Ebbs D, Taricia M, Funaro M, O’Daniel M, Cappello M. Prehospital use of point-of-care tests by community health workers: a scoping review. Frontiers In Public Health 2024, 12: 1360322. PMID: 38721545, PMCID: PMC11076783, DOI: 10.3389/fpubh.2024.1360322.Peer-Reviewed Original ResearchConceptsCommunity health workersHealth workersPoint-of-care testingPrehospital settingLocal community health workersFull-text reviewMedical Subject HeadingsPRISMA extensionPrehospital useImplementation strategiesResource settingsEarly risk stratificationMedical librariansStudy criteriaSubject headingsPoint-of-carePrehospitalRisk stratificationWorkersCommunitySetsReviewPRISMAHIVMalariaCentral Venous Catheter Consideration in Pediatric Oncology: A Systematic Review and Meta-analysis From the American Pediatric Surgical Association Cancer Committee
Christison-Lagay E, Brown E, Bruny J, Funaro M, Glick R, Dasgupta R, Grant C, Engwall-Gill A, Lautz T, Rothstein D, Walther A, Ehrlich P, Aldrink J, Rodeberg D, Baertschiger R. Central Venous Catheter Consideration in Pediatric Oncology: A Systematic Review and Meta-analysis From the American Pediatric Surgical Association Cancer Committee. Journal Of Pediatric Surgery 2024, 59: 1427-1443. PMID: 38637207, DOI: 10.1016/j.jpedsurg.2024.03.047.Peer-Reviewed Original ResearchCentral venous catheterIncreased risk of complicationsAbsolute neutrophil countRisk of complicationsIncreased riskCatheter placementCatheter compositionIncreased risk of hematomaTunneled central venous cathetersPlatelet count <Risk of hematomaMeta-analysisIncidence of complicationsLimited evidenceModern oncology practiceEnglish-language articlesCatheter salvageLock therapyNeutropenic patientsCatheter removalBloodstream infectionsTunneled cathetersPlatelet countNo significant differenceVenous cathetersMachine Learning For Mental Health: Focus on Affective and Nonaffective Psychosis
Ferrara M, Franchini G, Funaro M, Murri M, Toffanin T, Zerbinati L, Valier B, Ambrosio D, Marconi F, Cutroni M, Basaldella M, Seno S, Grassi L. Machine Learning For Mental Health: Focus on Affective and Nonaffective Psychosis. 2024, 239-258. DOI: 10.1201/9781003378068-11.Peer-Reviewed Original ResearchAntipsychotic agents in anxiety disorders: An umbrella review
Garakani A, Buono F, Salehi M, Funaro M, Klimowicz A, Sharma H, Faria C, Larkin K, Freire R. Antipsychotic agents in anxiety disorders: An umbrella review. Acta Psychiatrica Scandinavica 2024, 149: 295-312. PMID: 38382649, DOI: 10.1111/acps.13669.Peer-Reviewed Original ResearchSecond-generation antipsychoticsFirst-generation antipsychoticsGeneralized anxiety disorderStudies of antipsychoticsAnxiety disordersAntipsychotic agentsEfficacy of first-generation antipsychoticsTreatment of anxiety disordersEfficacy of antipsychotic agentsMeta-analysesAntidepressant treatmentNonantipsychotic medicationsAntipsychoticsFirst-line treatmentAnxietyComparing monotherapyUmbrella reviewDisordersQuetiapineSystematic reviewSide effectsAMSTAR-2Off-labelAPA PsycInfoCINAHL CompleteCorrection: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. Correction: On the proportion of patients who experience a prodrome prior to psychosis onset: a systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1567-1567. PMID: 38351175, DOI: 10.1038/s41380-024-02481-0.Peer-Reviewed Original ResearchOn the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis
Benrimoh D, Dlugunovych V, Wright A, Phalen P, Funaro M, Ferrara M, Powers A, Woods S, Guloksuz S, Yung A, Srihari V, Shah J. On the proportion of patients who experience a prodrome prior to psychosis onset: A systematic review and meta-analysis. Molecular Psychiatry 2024, 29: 1361-1381. PMID: 38302562, DOI: 10.1038/s41380-024-02415-w.Peer-Reviewed Original ResearchSources of heterogeneitySystematic reviewProportion of patientsMeta-analysisSubgroup analysisCochrane Database of Systematic ReviewsDatabase of Systematic ReviewsMeta-analysis of studies of patientsPsychosis onsetProspective cohort studyCochrane Central Register of Controlled TrialsCentral Register of Controlled TrialsRegister of Controlled TrialsAPA PsycInfoNarrative synthesisMeta-analysis estimatesCochrane Central RegisterPrevention of psychosisAscertainment methodsWeb of Science Core CollectionRecall biasQualitative studyAssess heterogeneityCohort studyOvid MEDLINENeural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis
Ibrahim K, Iturmendi-Sabater I, Vasishth M, Barron D, Guardavaccaro M, Funaro M, Holmes A, McCarthy G, Eickhoff S, Sukhodolsky D. Neural circuit disruptions of eye gaze processing in autism spectrum disorder and schizophrenia: An activation likelihood estimation meta-analysis. Schizophrenia Research 2024, 264: 298-313. PMID: 38215566, PMCID: PMC10922721, DOI: 10.1016/j.schres.2023.12.003.Peer-Reviewed Original ResearchConceptsRight inferior frontal gyrusAutism spectrum disorderInferior frontal gyrusEye gaze processingActivation likelihood estimationRight fusiform gyrusGaze processingFrontal gyrusFusiform gyrusFrontotemporal circuitryFunctional decodingSpectrum disorderActivation likelihood estimation meta-analysisMeta-analytic connectivity modelingMeta-analytic connectivityNeural circuit disruptionsTransdiagnostic biomarkerEmotional processingLeft amygdalaNeurobiological dysfunctionSocial cognitionEmotion perceptionNeural mechanismsSchizophreniaSpatial cognition
2023
Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsyClinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR)
Mishra N, Kwan P, Tanaka T, Sunnerhagen K, Dawson J, Zhao Y, Misra S, Wang S, Sharma V, Mazumder R, Funaro M, Ihara M, Nicolo J, Liebeskind D, Yasuda C, Cendes F, Quinn T, Ge Z, Scalzo F, Zelano J, Kasner S, Consortium I, Mishra N, Kwan P, Friedman A, Engel J. Clinical characteristics and outcomes of patients with post-stroke epilepsy: protocol for an individual patient data meta-analysis from the International Post-stroke Epilepsy Research Repository (IPSERR). BMJ Open 2023, 13: e078684. PMID: 37968000, PMCID: PMC10660442, DOI: 10.1136/bmjopen-2023-078684.Peer-Reviewed Original ResearchConceptsPost-stroke epilepsyPost-stroke seizuresIndividual patient dataClinical characteristicsLate post-stroke seizuresPatient dataOutcomes of patientsFuture clinical trialsPatient outcome measuresComprehensive search strategyAcute strokePeer-reviewed journalsStroke patientsPrognostic valueStroke mortalityBias assessmentClinical trialsObservational studyOutcome measuresLanguage of publicationEpileptic seizuresPatientsEthics approvalStudy authorsIPD-MAOutcomes in Patients With Poststroke Seizures
Misra S, Kasner S, Dawson J, Tanaka T, Zhao Y, Zaveri H, Eldem E, Vazquez J, Silva L, Mohidat S, Hickman L, Khan E, Funaro M, Nicolo J, Mazumder R, Yasuda C, Sunnerhagen K, Ihara M, Ross J, Liebeskind D, Kwan P, Quinn T, Engel J, Mishra N. Outcomes in Patients With Poststroke Seizures. JAMA Neurology 2023, 80: 1155-1165. PMID: 37721736, PMCID: PMC10507596, DOI: 10.1001/jamaneurol.2023.3240.Peer-Reviewed Original ResearchConceptsPoststroke seizuresPoor functional outcomeLate seizuresEarly seizuresStroke subtypesFunctional outcomeOdds ratioSystematic reviewJoanna Briggs Institute toolsHemorrhagic stroke subtypesOutcomes of patientsHistory of strokeTrials of interventionsRisk of biasMeta-Analyses (PRISMA) checklistPreferred Reporting ItemsMeta-regression analysisWeb of ScienceRecurrent strokeGreater disabilityPoor outcomeDementia riskSubgroup analysisBias assessmentEgger's testAdult Electronic Nicotine Delivery System Use in the USA: a Scoping Review Through a Health Equity Lens
Suttiratana S, Kong G, Li W, Ouellette R, Balasuriya L, Funaro M, Arnold C, Krishnan-Sarin S. Adult Electronic Nicotine Delivery System Use in the USA: a Scoping Review Through a Health Equity Lens. Current Addiction Reports 2023, 10: 825-836. PMID: 39372844, PMCID: PMC11452013, DOI: 10.1007/s40429-023-00521-3.Peer-Reviewed Original ResearchElectronic nicotine delivery systemsHealth equity lensElectronic nicotine delivery systems (ENDS) usePopulation health strategiesEquity lensNicotine delivery systemsUS National SurveyCigarette cessationIntervention trialsHealth strategiesENDS useHealth disparitiesReviewThe objectiveHealth equityHealth influencesDemographic characteristicsEthnic differencesLongitudinal studyScoping ReviewNational surveySummaryThe useMost studiesDelivery systemReviewLevel factorsA Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents
Aneni K, Meyer J, Funaro M, Pegram D, Umutoni F, Gomati de la Vega I, Jiao M, Fernandes C, Onyeaka H, Baiden P, Camenga D. A Systematic Review and Meta-Analysis Evaluating the Efficacy of Stand-Alone Digital Interventions to Prevent Substance Use Among Adolescents. Current Addiction Reports 2023, 10: 378-395. DOI: 10.1007/s40429-023-00508-0.Peer-Reviewed Original ResearchSubstance useTobacco useLarge effect sizesSystematic reviewDigital interventionsEffect sizeSystematic literature searchBooster sessionsPrevention servicesPacific Islander groupsTrial studySignificant effect sizePrevent Substance UseMeta-AnalysisCannabis useLiterature searchAlcohol useEthnic distributionInterventionSignificant reductionAdolescentsMultiple sessionsEfficacyCannabisNative American adolescents