2024
The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis
Sandhu M, Schonwald A, Boyko M, Jafar T, Freedman I, Woeste J, Kurup A, Funaro M, Zlotnik A, Gruenbaum S, Elsamadicy A, Reynolds R, Gruenbaum B. The association between female sex and depression following traumatic brain injury: A systematic review and meta-analysis. Neuroscience & Biobehavioral Reviews 2024, 168: 105952. PMID: 39603437, DOI: 10.1016/j.neubiorev.2024.105952.Peer-Reviewed Original ResearchPost-TBI depressionTraumatic brain injurySpectrum of TBI severityBrain injuryDiagnosis of depressionNeurobehavioral symptomsTBI severitySystematic reviewDepressionMeta-analysisStatistically significant differenceMedian ageFemale patientsPooled analysisFemale sexRisk factorsSevere casesParticipantsPotential associationSignificant differenceSexSeverityRiskInjurySubjects
2023
Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury
Misra S, Khan E, Lam T, Mazumder R, Gururangan K, Hickman L, Goswami V, Funaro M, Eldem E, Sansing L, Sico J, Quinn T, Liebeskind D, Montaner J, Kwan P, Mishra N. Common Pathways of Epileptogenesis in Patients With Epilepsy Post–Brain Injury. Neurology 2023, 101: e2243-e2256. PMID: 37550071, PMCID: PMC10727219, DOI: 10.1212/wnl.0000000000207749.Peer-Reviewed Original ResearchConceptsStandardized mean differencePoststroke epilepsyBrain injuryGenetic susceptibilityDisparate time pointsRisk of epileptogenesisLate-onset seizuresDevelopment of epilepsyBlood glucose levelsTraumatic brain injuryMean biomarker levelsIndividual genetic susceptibilityWeb of ScienceReported biomarkersPrimary outcomeEpileptogenic processBiofluid biomarkersBias assessmentBiomarker levelsCommon biological pathwaysEnrichment analysisGlucose levelsHigh riskPrognostic studiesEpilepsy