2024
Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study
Hoobler R, Puklin L, Harrigan M, Cartmel B, Li F, Sanft T, Ferrucci L, Irwin M, Playdon M. Baseline predictors associated with successful weight loss among breast cancer survivors in the Lifestyle, Exercise, and Nutrition (LEAN) study. Journal Of Cancer Survivorship 2024, 1-9. PMID: 39528779, DOI: 10.1007/s11764-024-01702-3.Peer-Reviewed Original ResearchBreast cancer survivorsClinically meaningful weight lossCancer survivorsWeight loss interventionCancer SurvivorsBreast cancer survivorsWeight loss successConclusionBreast cancer survivorsPrevention of weight gainAssociated with lower oddsHistory of weight gainHealthy body weightMultivariate logistic regressionCancer treatmentSuccessful weight lossBreast cancer treatmentIntervention armLower oddsResultsBaseline dataDesign of programsWeight lossLogistic regressionC-statisticWeight gainSurvivorsIntervention1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial
Ligibel J, Ballman K, mccall L, Goodwin P, Weiss A, Crane T, Irwin M, Thomson C, Hahn O, Spears P, Hershman D, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Winer E, Carey L, Partridge A. 1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial. Annals Of Oncology 2024, 35: s1078. DOI: 10.1016/j.annonc.2024.08.1913.Peer-Reviewed Original Research
2023
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin L, Li F, Cartmel B, Zhao J, Sanft T, Lisevick A, Winer E, Lustberg M, Spiegelman D, Sharifi M, Irwin M, Ferrucci L. Post-diagnosis weight trajectories and mortality among women with breast cancer. Npj Breast Cancer 2023, 9: 98. PMID: 38042922, PMCID: PMC10693588, DOI: 10.1038/s41523-023-00603-5.Peer-Reviewed Original ResearchBody mass indexBreast cancer diagnosisWeight changeCause mortalityClinical characteristicsWeight gainWeight lossBreast cancerWeight trajectoriesPost-diagnosis weight changeBreast cancer-specific mortalityCox proportional hazards modelModern treatment eraCancer-specific mortalityCancer diagnosisModerate weight lossModerate weight gainProportional hazards modelAdverse health outcomesElectronic health recordsTreatment eraBaseline characteristicsTumor RegistryMass indexWeight managementRandomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionDiet and physical activity interventions in Black and Latina women with breast cancer: A scoping review
Pichardo M, Sanft T, Ferrucci L, Romero-Ramos Y, Cartmel B, Harrigan M, Velazquez A, Fayanju O, Winer E, Irwin M. Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review. Frontiers In Oncology 2023, 13: 1079293. PMID: 36994212, PMCID: PMC10040823, DOI: 10.3389/fonc.2023.1079293.Peer-Reviewed Original ResearchBreast cancer survivorsPhysical activity interventionsLifestyle interventionCancer survivorsActivity interventionsLatina womenEfficacy trialsBreast cancerLatina breast cancer survivorsTrial of dietOne-year followFavorable behavioral changesBreast cancer diagnosisPrimary outcomeAvailable peer-reviewed literatureFuture trialsInformal care giversPilot trialSustained behavior changeEfficacy studiesHealthful lifestyleCare giversTrialsWeight lossCancer diagnosis
2022
Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors
Dieli-Conwright CM, Harrigan M, Cartmel B, Chagpar A, Bai Y, Li FY, Rimm DL, Pusztai L, Lu L, Sanft T, Irwin ML. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Npj Breast Cancer 2022, 8: 29. PMID: 35256599, PMCID: PMC8901848, DOI: 10.1038/s41523-022-00396-z.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionBreast tissue biopsiesUsual careLoss interventionCancer survivorsWeight lossBreast cancerTissue markersTissue biopsiesLifestyle behavioural interventionUsual care groupSerum insulin levelsWeight loss trialWeight loss groupBreast cancer treatmentBreast tissue markersInsulin receptor levelsInflammatory markersAdiponectin levelsSerum leptinCare groupInsulin levelsSerum biomarkersBlood draw
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenEffect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth recordsRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associationsExamining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2020
Energetics
Ferrucci L, Irwin M. Energetics. 2020, 303-320. DOI: 10.1007/978-3-030-42011-6_15.Peer-Reviewed Original ResearchWeight loss interventionCancer riskLoss interventionCancer outcomesRisk factorsReduced cancer riskIndependent risk factorEnergy balance interventionsDifferent cancer sitesDiet interventionPhysical inactivityDifferent cancer typesSurrogate markerCancer sitesBalance interventionsPhysical activityNew therapiesPoor dietObesityVaried age groupsAge groupsCancer typesCancer developmentMortalityWeight loss
2018
The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401).
Ligibel J, Barry W, Alfano C, Hershman D, Irwin M, Neuhouser M, Thomson C, Delahanty L, Frank E, Spears P, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Goodwin P, Carey L, Partridge A, Winer E. The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401). Journal Of Clinical Oncology 2018, 36: tps598-tps598. DOI: 10.1200/jco.2018.36.15_suppl.tps598.Peer-Reviewed Original Research
2011
Obesity and Cancer: Epidemiology
Irwin M. Obesity and Cancer: Epidemiology. Energy Balance And Cancer 2011, 1: 101-110. DOI: 10.1007/978-1-4419-9911-5_4.Peer-Reviewed Original ResearchA review of web‐based weight loss interventions in adults
Arem H, Irwin M. A review of web‐based weight loss interventions in adults. Obesity Reviews 2011, 12: e236-e243. PMID: 20804523, PMCID: PMC3086798, DOI: 10.1111/j.1467-789x.2010.00787.x.Peer-Reviewed Original ResearchConceptsWeight lossWeb-based weight loss interventionObesity-related health complicationsWeight loss interventionBurden of diseasePublic health practitionersInternet-delivered interventionsAssociated health consequencesLoss interventionLow adherenceHealthcare costsEfficacious interventionsHealth complicationsObesity ratesControl groupNon-Caucasian participantsHealth consequencesWeight gainHealth practitionersIntervention resultsDefinitive conclusionsPopulation-specific researchPeer-reviewed literatureInterventionMore males
2010
Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study
Irwin ML, Duggan C, Wang CY, Smith AW, McTiernan A, Baumgartner RN, Baumgartner KB, Bernstein L, Ballard-Barbash R. Fasting C-Peptide Levels and Death Resulting From All Causes and Breast Cancer: The Health, Eating, Activity, and Lifestyle Study. Journal Of Clinical Oncology 2010, 29: 47-53. PMID: 21115859, PMCID: PMC3055859, DOI: 10.1200/jco.2010.28.4752.Peer-Reviewed Original ResearchConceptsC-peptide levelsRisk of deathType 2 diabetesBreast cancerHazard ratioLifestyle StudyC-peptideDietary-induced weight lossSerum C-peptideCox regression analysisBody mass indexRegional breast cancerBreast cancer diagnosisMass indexInsulin secretionTreatment strategiesObservational studyEstrogen receptorPhysical activityCancerWeight lossCancer diagnosisCertain subgroupsWomenDeathPhysical Activity, Weight Control, and Cancer Prognosis
Schmitz K, Irwin M, Speck R. Physical Activity, Weight Control, and Cancer Prognosis. Energy Balance And Cancer 2010, 165-182. DOI: 10.1007/978-1-4419-7551-5_8.Peer-Reviewed Original ResearchPhysical activityExercise programCancer prognosisWeight controlMortality of cancerMajority of evidenceGastric cardiaCancer survivorsPoor prognosisBreast cancerBody weightColon cancerPrognosisCancerCancer treatmentWeight lossCancer diagnosisDiagnosisPatientsPersistent effectsEvidenceObesityCardiaEndometriumRecurrence