2009
Sleep Breathing Disorders in the U.S. Female Population
Kapsimalis F, Kryger M. Sleep Breathing Disorders in the U.S. Female Population. Journal Of Women's Health 2009, 18: 1211-1219. PMID: 19627224, PMCID: PMC2825714, DOI: 10.1089/jwh.2008.1054.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeU.S. female populationHigh riskBerlin questionnaireFemale populationCommon symptomsDaytime sleepinessMedical disordersPrimary care medical communityRestless legs syndrome symptomsChronic medical disordersSleep apnea syndromeSleep breathing disordersMenstrual cycle statusSleep onset insomniaSuch common symptomsNational Sleep FoundationAnnual telephone surveyHabitual snoringApnea syndromeBreathing disordersPostpartum womenCommon disorderSyndrome symptomsOnset insomniaExpenditure on Health Care in Obese Women with and without Sleep Apnea
Banno K, Ramsey C, Walld R, Kryger MH. Expenditure on Health Care in Obese Women with and without Sleep Apnea. Sleep 2009, 32: 247-252. PMID: 19238812, PMCID: PMC2635589, DOI: 10.1093/sleep/32.2.247.Peer-Reviewed Original ResearchConceptsNormal-weight controlsObese controlsObese womenOSAS casesWeight controlPhysician feesPhysician visitsTertiary university-based medical centerHealth servicesUniversity-based medical centerAge-matched womenEffect of obesityRetrospective observational studyTreatment of OSAOverall medical costsHealth care utilizationMore health servicesGreater financial burdenHealth care expendituresOSA casesCare utilizationSleep apneaObservational studyMedical CenterGeneral population
2008
Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K. Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea. Lung 2008, 186: 209-217. PMID: 18365276, DOI: 10.1007/s00408-008-9082-x.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea severityObstructive sleep apneaNon-OSA groupBody mass indexModerate OSAS groupCRP levelsInsulin resistanceApnea severityOSAS groupMale patientsLeptin levelsSleep apneaSevere obstructive sleep apnea syndromeHomeostasis model assessment methodSevere sleep apneaSevere OSAS groupSleep apnea syndromeC-reactive proteinTotal sleep timeNocturnal hypoxemiaApnea syndromeModel assessment methodHip ratioMass index
2007
Cytokines and pathological sleep
Kapsimalis F, Basta M, Varouchakis G, Gourgoulianis K, Vgontzas A, Kryger M. Cytokines and pathological sleep. Sleep Medicine 2007, 9: 603-614. PMID: 18024171, DOI: 10.1016/j.sleep.2007.08.019.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsMultiple biologic actionsObstructive sleep apneaExcessive daytime sleepinessNew biologic treatmentsChronic inflammatory diseaseHormonal regulatory mechanismsCardiovascular consequencesSleep apneaBiologic treatmentExcessive sleepinessSleep disturbancesDaytime sleepinessInflammatory diseasesSleep disordersCytokinesImmune systemBiologic actionsIntercellular mediatorsPathological sleepTarget tissuesSleepinessSleep lossImportant roleDisordersApnea
2005
Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center.
Banno K, Walld R, Kryger MH. Increasing obesity trends in patients with sleep-disordered breathing referred to a sleep disorders center. Journal Of Clinical Sleep Medicine 2005, 1: 364-6. PMID: 17564402, DOI: 10.5664/jcsm.26362.Peer-Reviewed Original ResearchConceptsSleep-related breathing disordersBody mass indexSleep disorders centerMean body mass indexDisorders CenterBMI unitsObesity trendsSleep-disordered breathingPrevalence of obesityTime of referralYear of referralNumber of patientsMale patientsFemale patientsMass indexBreathing disordersMean ageNew patientsPatientsSignificant positive correlationReferralWomenObesityRegression analysisSexDifferences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome
Shepertycky M, Banno K, Kryger MH. Differences between Men and Women in the Clinical Presentation of Patients Diagnosed with Obstructive Sleep Apnea Syndrome. Sleep 2005, 28: 309-314. PMID: 16173651, DOI: 10.1093/sleep/28.3.309.Peer-Reviewed Original ResearchConceptsEpworth Sleepiness Scale scoreApnea-hypopnea indexBody mass indexClinical presentationMass indexObstructive sleep apnea syndrome (OSA) resultsTertiary university-based medical centerScale scoreRetrospective chart review analysisObstructive sleep apnea syndromeUniversity-based medical centerLaboratory polysomnographic studiesMain presenting symptomChart review analysisUpper airway anatomySleep apnea syndromeHistory of depressionGender-related differencesLess alcohol consumptionPolysomnographic findingsPresenting symptomApnea syndromeHypothyroid diseasePolysomnographic studyPrimary complaint
2004
Review article: sleep and its relationship to gastro‐oesophageal reflux
Orr W, Heading R, Johnson L, Kryger M. Review article: sleep and its relationship to gastro‐oesophageal reflux. Alimentary Pharmacology & Therapeutics 2004, 20: 39-46. PMID: 15527463, DOI: 10.1111/j.1365-2036.2004.02239.x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGastro-oesophageal reflux diseaseReflux eventsObstructive sleep apnea syndromeMost symptomatic patientsGastro-oesophageal refluxSleep apnea syndromeSlow gastric emptyingCommon gastrointestinal conditionsFrequency of swallowingReflux diseaseRespiratory complicationsSymptomatic patientsApnea syndromeGastric emptyingDecreased qualitySaliva productionPatientsSleepGastrointestinal conditionsPhysiological changesClearance behaviorConscious perceptionHeartburnComplicationsObesity
2002
Gender and Obstructive Sleep Apnea Syndrome, Part 2: Mechanisms
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 2: Mechanisms. Sleep 2002, 25: 497-504. PMID: 12150315, DOI: 10.1093/sleep/25.5.497.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeUpper airway muscle functionHormone replacement therapyUpper airway anatomySleep breathing disordersControl of ventilationOSAS prevalenceBreathing disordersReplacement therapySex hormonesCommon disorderFemale genderMuscle functionEpidemiologic studiesAdipose tissueSyndromeDisordersAdult malesGenderRiskFemalesPercentObesityGender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features
Kapsimalis F, Kryger MH. Gender and Obstructive Sleep Apnea Syndrome, Part 1: Clinical Features. Sleep 2002, 25: 409-416. PMID: 12071542, DOI: 10.1093/sleep/25.4.409.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsObstructive sleep apnea syndromeSleep apnea syndromeApnea syndromeGeneral populationPrevalence of OSASOSAS casesPolysomnography findingsMale predominanceClinical featuresClinical presentationFemale patientsClinic populationEpidemiologic studiesPathophysiologic studiesSyndromeFemalesMalesPopulationLatest studiesPatientsPrevalenceDiseaseStudyOnly malesWomenWhat Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis?
Smith R, Ronald J, Delaive K, Walld R, Manfreda J, Kryger MH. What Are Obstructive Sleep Apnea Patients Being Treated for Prior to This Diagnosis? CHEST Journal 2002, 121: 164-172. PMID: 11796446, DOI: 10.1378/chest.121.1.164.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeBody mass indexChronic obstructive airways diseaseObstructive airways diseaseHealth care utilizationSleep apnea patientsControl subjectsApnea patientsAirway diseaseOSAS patientsCardiovascular diseaseObstructive sleep apnea patientsHealth care utilization measuresApnea-hypopnea indexCongestive heart failureEffect of obesityIschemic heart diseaseSleep apnea syndromeDegree of hypoxemiaSignificant independent predictorsLogistic regression analysisCertain cardiovascular disordersHealth care resourcesRegression analysisApnea syndrome
2001
The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome
Berg G, Delaive K, Manfreda J, Walld R, Kryger M. The Use of Health-Care Resources in Obesity-Hypoventilation Syndrome. CHEST Journal 2001, 120: 377-383. PMID: 11502632, DOI: 10.1378/chest.120.2.377.Peer-Reviewed Original ResearchConceptsGeneral population control subjectsObese control subjectsObesity hypoventilation syndromeInitiation of treatmentOHS patientsControl subjectsRetrospective observational cohort studyObservational cohort studyMeasurement of BMISleep breathing disordersHealth care utilizationPopulation control subjectsSleep disorders centerHealth care resourcesCohort studyPhysician visitsBreathing disordersDisorders CenterPatientsControl groupDiagnosisPhysician feesHealth careVisitsTreatment
2000
Diagnosis and management of sleep apnea syndrome
Kryger M. Diagnosis and management of sleep apnea syndrome. Clinical Cornerstone 2000, 2: 39-44. PMID: 10875045, DOI: 10.1016/s1098-3597(00)90039-5.Peer-Reviewed Original ResearchConceptsSleep apnea syndromeApnea syndromeContinuous positive airway pressureMain presenting symptomPositive airway pressureSleep breathing disordersConstellation of signsPresenting symptomAirway pressureMost patientsExcessive daytimeSleep apneaBreathing disordersAbnormal breathingComplete resolutionSleep disruptionBusy cliniciansSymptomsSyndromeSleepDiagnosisDisordersEpisodesHypoxemiaApnea
1996
Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea
Kryger M, Roos L, Delaive K, Walld R, Horrocks J. Utilization of Health Care Services in Patients With Severe Obstructive Sleep Apnea. Sleep 1996, 19: s111-s116. PMID: 9122567, DOI: 10.1093/sleep/19.suppl_9.s111.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaHealth care servicesSleep apneaControl groupCare servicesSevere obstructive sleep apneaHealth care utilizationSleep apnea patientsObese patientsOSA patientsCare utilizationInitial diagnosisOSA groupControl subjectsApnea patientsHospital costsPhysician claimsPatientsApneaControl counterpartsHeavy consumersSpecific evaluationGroupTotal expenditureHospital
1995
Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders?
Yamashiro Y, Kryger M. Nocturnal Oximetry: Is It a Screening Tool for Sleep Disorders? Sleep 1995, 18: 167-171. PMID: 7610312, DOI: 10.1093/sleep/18.3.167.Peer-Reviewed Original ResearchConceptsUpper airway resistance syndromeExcessive daytime sleepinessHome oximetrySleep disordersSevere OSA patientsTertiary referral hospitalPeriodic limb movementsSleep disorders centerNumber of desaturationsSleep-breathing disordersDisorders of sleepOxygen saturation dataMild OSAOSA patientsPolysomnographic diagnosisReferral hospitalSleep apneaResistance syndromeDaytime sleepinessDisorders CenterBlinded comparisonClinical diagnosisOximetryPolysomnographyPatients
1988
Sleep Apnea and Body Position during Sleep
George C, Millar T, Kryger M. Sleep Apnea and Body Position during Sleep. Sleep 1988, 11: 90-99. PMID: 3363274, DOI: 10.1093/sleep/11.1.90.Peer-Reviewed Original ResearchConceptsApnea-hypopnea indexRapid eye movementLateral decubitus positionApnea durationObese patientsSleep apneaDecubitus positionBody positionSleep stagesSevere sleep apneaObstructive sleep apneaNon-REM sleepMajor treatment interventionApnea frequencyOvernight studyPatientsTreatment interventionsApneaNREMEye movementsSleepPrevious studiesPolysomnogramSupinePosition changes
1987
Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100
West P, George C, Kryger M. Dynamic in Vivo Response Characteristics of Three Oximeters: Hewlett-Packard 47201A, Biox III, and Nellcor N-100. Sleep 1987, 10: 263-271. PMID: 3629089, DOI: 10.1093/sleep/10.3.263.Peer-Reviewed Original ResearchConceptsOxygen saturation measurementsHeart rateSaO2 measurementsOxygen saturationSleep apnea syndrome patientsArterial oxygen saturationPulse oximeterHewlett-Packard 47201ASyndrome patientsLinear regression analysisSaturation measurementsNellcor NOximeter sensorBiox IIIOximeterPatientsRegression analysisResponse relationshipSleepPulse oximeter sensorSaO2
1986
Sleep in Restrictive Lung Disease
George C, Kryger M. Sleep in Restrictive Lung Disease. Sleep 1986, 10: 409-418. PMID: 3317724, DOI: 10.1093/sleep/10.5.409.Peer-Reviewed Original ResearchConceptsInterstitial lung diseaseLung diseaseNocturnal oxygenNocturnal desaturationMuscle weaknessLung disease patientsRestrictive lung diseaseFibrotic lung diseaseUse of drugsFurther hypoxemiaNocturnal hypoxemiaNasal CPAPNocturnal hypoventilationAcute alveolitisLong-term evaluationRestrictive diseaseOxygenation abnormalitiesDisease patientsKyphoscoliosis patientsDeformity changesSleep changesSleep architectureSleep structureNeuromuscular diseasePatients
1985
Fat, Sleep, and Charles Dickens: literary and Medical Contributions to the Understanding of Sleep Apnea
Kryger M. Fat, Sleep, and Charles Dickens: literary and Medical Contributions to the Understanding of Sleep Apnea. Clinics In Chest Medicine 1985, 6: 555-562. PMID: 3910333, DOI: 10.1016/s0272-5231(21)00394-4.Peer-Reviewed Original Research
1983
Sleep apnea. From the needles of Dionysius to continuous positive airway pressure.
Kryger M. Sleep apnea. From the needles of Dionysius to continuous positive airway pressure. JAMA Internal Medicine 1983, 143: 2301-3. PMID: 6360064, DOI: 10.1001/archinte.143.12.2301.Peer-Reviewed Original ResearchThe role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. Bulletin Européen De Physiopathologie Respiratoire 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths