2015
Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease
Sun H, Palcza J, Rosenberg R, Kryger M, Siringhaus T, Rowe J, Lines C, Wagner JA, Troyer MD. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 2015, 109: 416-426. PMID: 25661282, DOI: 10.1016/j.rmed.2014.12.010.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAzepinesCross-Over StudiesDouble-Blind MethodFemaleHumansMaleMiddle AgedOrexin Receptor AntagonistsPulmonary Disease, Chronic ObstructiveRespirationSeverity of Illness IndexSleepSleep Aids, PharmaceuticalSpirometryTreatment OutcomeTriazolesUnited StatesConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseSleep breathing disordersOrexin receptor antagonistPulmonary diseaseBreathing disordersReceptor antagonistModerate chronic obstructive pulmonary diseaseDay 4Effects of suvorexantModerate airflow limitationRespiratory depressant effectsApnea-hypopnea indexMaximum daily doseClinical research unitTotal sleep timeTreatment of insomniaMean AHICOPD patientsAirflow limitationHypopnea indexDaily doseMean SpO2Spirometry criteriaHypnotic medications
2008
The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease
Kryger M, Roth T, Wang-Weigand S, Zhang J. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep And Breathing 2008, 13: 79-84. PMID: 18584227, DOI: 10.1007/s11325-008-0196-4.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultComorbidityCross-Over StudiesDouble-Blind MethodFemaleHumansIndenesMaleOximetryPolysomnographyPulmonary Disease, Chronic ObstructiveReceptors, MelatoninSeverity of Illness IndexSleep Apnea SyndromesSleep Apnea, ObstructiveSleep Initiation and Maintenance DisordersSleep StagesYoung AdultConceptsSevere chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseEffects of ramelteonObstructive pulmonary diseasePulmonary diseaseMean SaO2Respiratory depressant effectsApnea-hypopnea indexPoor sleep qualityTotal sleep timeMelatonin receptor agonistResultsNo significant differencesSignificant differencesAbnormal breathing eventsRamelteon 8Primary endpointAdverse eventsPersistent sleepCrossover studyDepressant effectPolysomnographic monitoringReceptor agonistRespiratory effortInsomnia treatmentSleep qualityAssociation of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea
Kapsimalis F, Varouchakis G, Manousaki A, Daskas S, Nikita D, Kryger M, Gourgoulianis K. Association of Sleep Apnea Severity and Obesity with Insulin Resistance, C-Reactive Protein, and Leptin Levels in Male Patients with Obstructive Sleep Apnea. Lung 2008, 186: 209-217. PMID: 18365276, DOI: 10.1007/s00408-008-9082-x.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea severityObstructive sleep apneaNon-OSA groupBody mass indexModerate OSAS groupCRP levelsInsulin resistanceApnea severityOSAS groupMale patientsLeptin levelsSleep apneaSevere obstructive sleep apnea syndromeHomeostasis model assessment methodSevere sleep apneaSevere OSAS groupSleep apnea syndromeC-reactive proteinTotal sleep timeNocturnal hypoxemiaApnea syndromeModel assessment methodHip ratioMass index
2007
Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD
Kryger M, Wang-Weigand S, Zhang J, Roth T. Effect of Ramelteon, a selective MT1/MT2-receptor agonist, on respiration during sleep in mild to moderate COPD. Sleep And Breathing 2007, 12: 243-250. PMID: 18060441, DOI: 10.1007/s11325-007-0156-4.Peer-Reviewed Original ResearchConceptsModerate chronic obstructive pulmonary diseaseChronic obstructive pulmonary diseaseAbnormal breathing eventsSelective MT1/MT2 receptor agonistMT1/MT2 receptor agonistMean apnea-hypopnea indexBreathing eventsEffects of ramelteonMT2 receptor agonistSingle bedtime doseApnea-hypopnea indexObstructive pulmonary diseaseNumber of awakeningsTotal sleep timeMelatonin receptor agonistBedtime dosePlacebo groupAdverse eventsPulmonary diseaseCrossover studyPhysical examinationReceptor agonistSleep efficiencySleep durationSleep time
2006
Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment
Banno K, Manfreda J, Walld R, Delaive K, Kryger MH. Healthcare Utilization in Women with Obstructive Sleep Apnea Syndrome 2 Years After Diagnosis and Treatment. Sleep 2006, 29: 1307-1311. PMID: 17068984, DOI: 10.1093/sleep/29.10.1307.Peer-Reviewed Original ResearchMeSH KeywordsBody Mass IndexContinuous Positive Airway PressureCosts and Cost AnalysisFemaleHumansMiddle AgedPolysomnographySeverity of Illness IndexSleep Apnea, ObstructiveConceptsObstructive sleep apnea syndromeContinuous positive airway pressureClinic visitsHealthcare utilizationWeight lossTertiary university-based medical centerRetrospective observational cohort studyEntire groupUniversity-based medical centerTreatment-compliant patientsObservational cohort studyPositive airway pressureSleep apnea syndromeAirway pressureCohort studyCompliant patientsApnea syndromePhysician claimsMedical CenterWL groupGeneral populationPatientsDiagnosisVisitsWomenGender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome
Vagiakis E, Kapsimalis F, Lagogianni I, Perraki H, Minaritzoglou A, Alexandropoulou K, Roussos C, Kryger M. Gender differences on polysomnographic findings in Greek subjects with obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 424-430. PMID: 16740405, DOI: 10.1016/j.sleep.2005.12.014.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeApnea-hypopnea indexBody mass indexSleep apnea syndromeMale patientsApnea syndromeFemale patientsOnset latencyMean apnea-hypopnea indexSleep apnea hypopnea indexHigher apnea-hypopnea indexNon-rapid eye movement sleepSleep disorders centerREM onset latencyEye movement sleepAthens Medical SchoolPercent of menSleep efficiency indexTotal sleep timeGreek subjectsAspects of sleepSleep onset latencyNorth American clinicsEvangelismos HospitalNREM-AHIHyperthyroidism in a patient referred for an assessment of obstructive sleep apnea syndrome
Banno K, Okamura K, Kryger MH. Hyperthyroidism in a patient referred for an assessment of obstructive sleep apnea syndrome. Sleep Medicine 2006, 7: 195-196. PMID: 16458602, DOI: 10.1016/j.sleep.2005.09.001.Peer-Reviewed Original Research
2005
Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease
Singh H, Pollock R, Uhanova J, Kryger M, Hawkins K, Minuk GY. Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease. Digestive Diseases And Sciences 2005, 50: 2338-2343. PMID: 16416185, DOI: 10.1007/s10620-005-3058-y.Peer-Reviewed Original ResearchConceptsNonalcoholic fatty liver diseaseSymptoms of OSANonalcoholic fatty liverObstructive sleep apneaFatty liver diseaseNAFLD patientsNASH patientsNonalcoholic steatohepatitisRisk factorsLiver diseaseSleep apneaInsulin resistancePrevalence of OSASleep apnea questionnaireIndependent risk factorPrevalence of diabetesBody mass indexPeripheral insulin resistanceLiver biopsyFatty liverMass indexTriglyceride levelsQuestionnaire criteriaPrevalence ratesPatientsUtilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP
Albarrak M, Banno K, Al. Sabbagh AA, Delaive K, Walld R, Manfreda J, Kryger MH. Utilization of Healthcare Resources in Obstructive Sleep Apnea Syndrome: a 5Year Follow-Up Study in Men Using CPAP. Sleep 2005, 28: 1306-1311. PMID: 16295216, DOI: 10.1093/sleep/28.10.1306.Peer-Reviewed Original ResearchConceptsObstructive sleep apnea syndromeSleep apnea syndromeIschemic heart diseaseHealthcare utilizationApnea syndromeHeart diseaseTreatment of OSASContinuous positive airway pressure useUntreated obstructive sleep apnea syndromeRetrospective observational cohort studyPositive airway pressure useEpworth Sleepiness Scale scoreLong-term health benefitsHigher healthcare utilizationObservational cohort studyApnea-hypopnea indexBody mass indexCPAP treatmentCohort studyPhysician visitsMass indexEligible menOSAS diagnosisFifth yearOSA diagnosis
2002
Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist
Kryger M, Walld R, Manfreda J. Diagnoses Received by Narcolepsy Patients in the Year Prior to Diagnosis by a Sleep Specialist. Sleep 2002, 25: 36-41. PMID: 11833859, DOI: 10.1093/sleep/25.1.36.Peer-Reviewed Original ResearchConceptsOnset of symptomsSleep disorders centerCorrect diagnosisNarcolepsy patientsDisorders CenterManitoba Health databaseDiagnosis of narcolepsyNervous system disordersLonger intervalsClinical featuresExcessive daytimeNarcolepsy diagnosisNeurologic conditionsControl subjectsHypnagogic hallucinationsGeneral practitionersNeurologic disordersTeaching hospitalDoctor visitsNocturnal sleepSevere symptomatologySystem disordersGeneral populationSleep specialistsSpecialist evaluation
1997
Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography
Pouliot Z, Peters M, Neufeld H, Kryger M. Using Self-Reported Questionnaire Data to Prioritize OSA Patients for Polysomnography. Sleep 1997, 20: 232-236. PMID: 9178919, DOI: 10.1093/sleep/20.3.232.Peer-Reviewed Original ResearchConceptsBody mass indexEpworth Sleepiness ScaleObstructive sleep apneaSimple clinical dataPercent of casesAnalysis of receiverHundreds of patientsLow AIObserved apneaApnea indexOSA patientsConsecutive patientsSleep apneaMass indexSelf-reported questionnaire dataClinical dataSleepiness ScalePatientsApneaPolysomnographyCharacteristic curveQuestionnaire dataGroupQuestionnaireSubjects