1987
Trial of a Dopaminergic Antidepressant in Obstructive Sleep Apnea
George C, West P, Millar T, Kryger M. Trial of a Dopaminergic Antidepressant in Obstructive Sleep Apnea. Sleep 1987, 10: 180-183. PMID: 3589330, DOI: 10.1093/sleep/10.2.180.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaAnticholinergic side effectsSleep apneaSide effectsImmune hemolytic anemiaCentral nervous system stimulant propertiesPharmacologic therapyUseful therapyEffective therapyUnacceptable incidenceDopaminergic antidepressantsHemolytic anemiaNomifensineRigorous scientific testingStimulant propertiesTherapyApneaAntidepressantsPatientsAnemiaDopaminergicIncidenceTrialsScientific testingProtriptyline
1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. Bulletin Européen De Physiopathologie Respiratoire 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolence