1994
Ventilatory Instability in Patients With Congestive Heart Failure and Nocturnal Cheyne-Stokes Breathing
Ahmed M, Serrette C, Kryger M, Anthonisen N. Ventilatory Instability in Patients With Congestive Heart Failure and Nocturnal Cheyne-Stokes Breathing. Sleep 1994, 17: 527-534. PMID: 7809566, DOI: 10.1093/sleep/17.6.527.Peer-Reviewed Original ResearchConceptsCongestive heart failureCheyne-Stokes breathingAir-breathing controlsShort-term potentiationHeart failureCirculatory delayAge-matched normalsEnd-tidal CO2Air-breathing levelsAlveolar hypoxiaCHF patientsHyperoxic ventilationVentilatory instabilityVentilatory patternHypoxic hyperventilationPatient ventilationBreathing controlBreathing patternPatientsHyperoxiaVentilationHypoxiaProlonged circulation timeCompared resultsBrief exposure
1980
The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3
Fleetham J, Bradley C, Kryger M, Anthonisen N. The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 833-40. PMID: 6779682, DOI: 10.1164/arrd.1980.122.6.833.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseHypoxemic chronic obstructive pulmonary diseaseOxygen therapyHypoxic responseLow-flow oxygen therapyCentral ventilatory driveFlow oxygen therapyNocturnal oxygen therapyObstructive pulmonary diseaseArterial O2 saturationNocturnal oxygenPulmonary diseaseSuch patientsVentilatory driveMinute ventilationInspiratory flowO2 saturationPatientsTherapyContinuous oxygenMonthsHypoxiaInitial responseHypoxemiaVentilation
1978
Familial aspects of decreased hypoxic drive in endurance athletes
Scoggin C, Doekel R, Kryger M, Zwillich C, Weil J. Familial aspects of decreased hypoxic drive in endurance athletes. Journal Of Applied Physiology 1978, 44: 464-468. PMID: 632187, DOI: 10.1152/jappl.1978.44.3.464.Peer-Reviewed Original ResearchConceptsVentilatory responseEndurance athletesLong-distance runnersHypoxic ventilatory responseUnexplained respiratory failureFamilies of patientsHypercapnic responseRespiratory failureVentilatory responsivenessEndurance athleticsHealthy parentsShape parameter ANonathletic controlsHypoxic responseHypoxiaSimilar extentFamilial aspectsHypercapniaConsequence of conditioningAthletesRecent studiesFamilial influencesRunnersResponsePatients
1976
Depression of Hypoxic Ventilatory Response by Nitrous Oxide
Yacoub O, Doell D, Kryger M, Anthonisen N. Depression of Hypoxic Ventilatory Response by Nitrous Oxide. Anesthesiology 1976, 45: 385-389. PMID: 973689, DOI: 10.1097/00000542-197610000-00006.Peer-Reviewed Original ResearchClinical Semi-Starvation — Depression of Hypoxic Ventilatory Response
Doekel R, Zwillich C, Scoggin C, Kryger M, Weil J. Clinical Semi-Starvation — Depression of Hypoxic Ventilatory Response. New England Journal Of Medicine 1976, 295: 358-361. PMID: 819829, DOI: 10.1056/nejm197608122950703.Peer-Reviewed Original ResearchConceptsHypoxic ventilatory responseVentilatory responseHypercapnic ventilatory responseMetabolic rateRespiratory failureIntravenous fluidsDecreased metabolic rateCarbohydrate dietNormal subjectsCaloric restrictionDay 10HypercapniaSupplemental electrolytesResponse responseSubjectsResponseHypoxemiaDecreaseHypoxiaAlimentationEffect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3
Kryger M, Yacoub O, Dosman J, Macklem P, Anthonisen N. Effect of Meperidine on Occlusion Pressure Responses to Hypercapnia and Hypoxia with and without External Inspiratory Resistance1–3. American Journal Of Respiratory And Critical Care Medicine 1976, 114: 333-40. PMID: 973724, DOI: 10.1164/arrd.1976.114.2.333.Peer-Reviewed Original ResearchConceptsInspiratory resistanceNormal subjectsOcclusion pressure responsesInspiratory motor outputEffect of meperidineOral meperidineVentilatory responseAcute increaseInspiratory effortClosed airwayMeperidineHypercapniaProgressive hypoxiaMotor outputMore depressionHypoxiaHypoxic responsePressure responseP0.1Combination of resistanceSubjectsResponseAirway
1975
Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia
Kryger M, Yacoub O, Anthonisen N. Effect of inspiratory resistance on occlusion pressure in hypoxia and hypercapnia. Respiratory Physiology & Neurobiology 1975, 24: 241-248. PMID: 1188196, DOI: 10.1016/0034-5687(75)90016-x.Peer-Reviewed Original Research