1987
Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease
Kryger M, Rogelio P, Conway W, Roth T, Anthonisen N, George C. Hypercapnia and Sleep O2 Desaturation in Chronic Obstructive Pulmonary Disease. Sleep 1987, 10: 216-223. PMID: 3629083, DOI: 10.1093/sleep/10.3.216.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseBlue bloatersPink puffersSleep hypoxemiaPulmonary diseaseO2 desaturationHypoxemic chronic obstructive pulmonary diseaseNocturnal Oxygen Therapy TrialBetter lung functionArterial blood gasesWide clinical spectrumHypercapnic patientsSame PaO2Sleep oxygenationSleep SaO2Airflow obstructionHypoxemic patientsPulmonary hypertensionCOPD populationHypercapnic groupMost patientsNormocapnic patientsLung functionBlood gases
1980
The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3
Fleetham J, Bradley C, Kryger M, Anthonisen N. The Effect of Low Flow Oxygen Therapy on the Chemical Control of Ventilation in Patients with Hypoxemic COPD1–3. American Journal Of Respiratory And Critical Care Medicine 1980, 122: 833-40. PMID: 6779682, DOI: 10.1164/arrd.1980.122.6.833.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseHypoxemic chronic obstructive pulmonary diseaseOxygen therapyHypoxic responseLow-flow oxygen therapyCentral ventilatory driveFlow oxygen therapyNocturnal oxygen therapyObstructive pulmonary diseaseArterial O2 saturationNocturnal oxygenPulmonary diseaseSuch patientsVentilatory driveMinute ventilationInspiratory flowO2 saturationPatientsTherapyContinuous oxygenMonthsHypoxiaInitial responseHypoxemiaVentilation