1983
The role of protriptyline in obstructive sleep apnea.
Brownell L, Perez-Padilla R, West P, Kryger M. The role of protriptyline in obstructive sleep apnea. Bulletin Européen De Physiopathologie Respiratoire 1983, 19: 621-4. PMID: 6360257.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTreatment of mildLong-term treatmentTricyclic agentsObese patientsObstructive apneaClinical statusCrossover trialImproved oxygenationInvasive treatmentTerm treatmentPatientsApneaArousal frequencySomnolenceProtriptylineTreatmentTrialsOxygenationREMTherapyMildMonths
1982
Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial
Brownell L, West P, Sweatman P, Acres J, Kryger M. Protriptyline in Obstructive Sleep Apnea — A Double-Blind Trial. New England Journal Of Medicine 1982, 307: 1037-1042. PMID: 6750396, DOI: 10.1056/nejm198210213071701.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaSleep apneaTotal sleep timeApnea timeApnea durationBody weightSleep timeDouble-blind crossover studyDouble-blind trialMonths of treatmentWeeks of treatmentNocturnal oxygenationREM reductionDaytime somnolenceCrossover studyTricyclic antidepressantsApneaArousal frequencySimilar decreaseProtriptylineSimilar improvementsTreatmentOxygenationDurationSomnolenceSleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease
Fleetham J, West P, Mezon B, Conway W, Roth T, Kryger M. Sleep, Arousals, and Oxygen Desaturation in Chronic Obstructive Pulmonary Disease. American Journal Of Respiratory And Critical Care Medicine 1982, 126: 429-33. PMID: 7125332, DOI: 10.1164/arrd.1982.126.3.429.Peer-Reviewed Original ResearchConceptsOxygen desaturationArousal frequencySleep qualityChronic obstructive pulmonary diseaseAge-matched normal subjectsLower mean SaO2Role of hypoxemiaArterial oxygen desaturationObstructive pulmonary diseaseRoom air breathingArterial O2 saturationPoor sleep qualityReduced sleep timeSleep stage changesApneic episodesPulmonary functionOxygen therapyPulmonary diseaseSupplemental oxygenMean SaO2Sleep disruptionREM sleepNormal subjectsO2 saturationPatients