2019
Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells
Chioccioli M, Feriani L, Kotar J, Bratcher PE, Cicuta P. Phenotyping ciliary dynamics and coordination in response to CFTR-modulators in Cystic Fibrosis respiratory epithelial cells. Nature Communications 2019, 10: 1763. PMID: 30992452, PMCID: PMC6467870, DOI: 10.1038/s41467-019-09798-3.Peer-Reviewed Original ResearchConceptsHuman airway epithelial cellsEpithelial cellsCystic fibrosis respiratory epithelial cellsAirway epithelial cellsRespiratory epithelial cellsCiliary beat frequencyCiliary beatingRespiratory disordersRespiratory diseaseClinical observationsCystic fibrosisDrug efficacyPilot studyDrug testingEfficient drugsDrugsIndividual donorsEfficacyDrug screeningBeat dynamicsCellsSame genotypeFibrosisDonorsDisease
2017
Phototaxis beyond turning: persistent accumulation and response acclimation of the microalga Chlamydomonas reinhardtii
Arrieta J, Barreira A, Chioccioli M, Polin M, Tuval I. Phototaxis beyond turning: persistent accumulation and response acclimation of the microalga Chlamydomonas reinhardtii. Scientific Reports 2017, 7: 3447. PMID: 28615673, PMCID: PMC5471259, DOI: 10.1038/s41598-017-03618-8.Peer-Reviewed Original ResearchConceptsChlamydomonas reinhardtiiModel organism Chlamydomonas reinhardtiiMicroalga Chlamydomonas reinhardtiiPhototactic motilityEukaryotic microalgaeChlorophyll fluorescenceFlagellar activitySingle cellsReinhardtiiPhototaxisPhototactic responsePopulation levelAdaptation dynamicsCell steeringMicroorganismsPersistent accumulationLight exposure historyStriking quantitative agreementCellsFirst quantitative studyChlamydomonasPhotosynthesisAcclimationMicroalgaeMotility