2021
Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eating
2018
Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study
Sanft T, Usiskin I, Harrigan M, Cartmel B, Lu L, Li FY, Zhou Y, Chagpar A, Ferrucci LM, Pusztai L, Irwin ML. Randomized controlled trial of weight loss versus usual care on telomere length in women with breast cancer: the lifestyle, exercise, and nutrition (LEAN) study. Breast Cancer Research And Treatment 2018, 172: 105-112. PMID: 30062572, DOI: 10.1007/s10549-018-4895-7.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsWeight loss interventionUsual care groupBody mass indexBreast cancer riskCancer survivorsUsual careLoss interventionBreast cancerStage 0Quantitative polymerase chain reactionCare groupTelomere lengthCancer riskStage II/III breast cancerObese breast cancer survivorsWeight lossI breast cancerNon-Hispanic whitesPurposeSome studiesMass indexIntervention groupPhysical activityBlood samplesConclusionOur findingsExercise and weight loss interventions and miRNA expression in women with breast cancer
Adams BD, Arem H, Hubal MJ, Cartmel B, Li F, Harrigan M, Sanft T, Cheng CJ, Pusztai L, Irwin ML. Exercise and weight loss interventions and miRNA expression in women with breast cancer. Breast Cancer Research And Treatment 2018, 170: 55-67. PMID: 29511965, PMCID: PMC6444907, DOI: 10.1007/s10549-018-4738-6.Peer-Reviewed Original ResearchConceptsBaseline body mass indexBC survivorsTumor recurrenceWeight gainWeight lossBreast cancer survivorsSerum miRNA expressionWeight loss interventionBody mass indexWeight loss trialCancer-related deathIndependent clinical trialsMiRNA expressionSix-month interventionCanonical pathwaysTop canonical pathwaysPhysical exercise trialsIngenuity Pathway AnalysisIngenuity Pathway Analysis softwareSporadic BCDevelopment of cancerLoss interventionMass indexCancer survivorsExercise trials
2016
Response
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Response. Journal Of The National Cancer Institute 2016, 108: djw024. PMID: 26933009, DOI: 10.1093/jnci/djw024.Commentaries, Editorials and Letters
2015
Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis
Playdon MC, Bracken MB, Sanft TB, Ligibel JA, Harrigan M, Irwin ML. Weight Gain After Breast Cancer Diagnosis and All-Cause Mortality: Systematic Review and Meta-Analysis. Journal Of The National Cancer Institute 2015, 107: djv275. PMID: 26424778, PMCID: PMC4715249, DOI: 10.1093/jnci/djv275.Peer-Reviewed Original ResearchConceptsBody mass indexBreast cancer-specific mortalityCancer-specific mortalityCause mortalityWeight gainBreast cancer diagnosisBreast cancerStage I-IIIC breast cancerSystematic reviewPrediagnosis body mass indexWomen age 18 yearsPostdiagnosis weight gainCancer diagnosisCause mortality ratesBreast cancer mortalityAge 18 yearsWeb of ScienceCohort studyRecurrence outcomesMass indexCancer mortalityClinical trialsHigh riskMortality rateBody weight