2020
Actin flow-dependent and -independent force transmission through integrins
Driscoll TP, Ahn SJ, Huang B, Kumar A, Schwartz MA. Actin flow-dependent and -independent force transmission through integrins. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 32413-32422. PMID: 33262280, PMCID: PMC7768777, DOI: 10.1073/pnas.2010292117.Peer-Reviewed Original ResearchConceptsActin binding siteProtein interactionsDistinct protein interactionsDynamic protein interactionsIntegrin-dependent adhesionBinding sitesSubstrate stiffnessActin flowActin filamentsStiff substratesExtracellular matrixTalinVinculinIntegrinsReciprocal exchangeClutchesForce transmissionAdhesionFlow-independent mechanismsLarge adhesionABS3Cell edgeABS2SitesInteraction
1982
A new radioactive cross-linking reagent for studying the interactions of proteins.
Schwartz M, Das O, Hynes R. A new radioactive cross-linking reagent for studying the interactions of proteins. Journal Of Biological Chemistry 1982, 257: 2343-2349. PMID: 7061425, DOI: 10.1016/s0021-9258(18)34928-7.Peer-Reviewed Original ResearchConceptsCross-linking reagentInteraction of proteinsChemical cross-linking reagentsBinding of gelatinCovalent derivativesChemical behaviorSecond moleculeNeighboring macromoleculesN-succinimidyl propionateReagentsHigh yieldsBiological systemsNitro-4DerivativesBiological conditionsPhotolysisMacromoleculesMoleculesInteractionGelatinSituSurfaceYield