2021
Early events in endothelial flow sensing
Tanaka K, Joshi D, Timalsina S, Schwartz MA. Early events in endothelial flow sensing. Cytoskeleton 2021, 78: 217-231. PMID: 33543538, DOI: 10.1002/cm.21652.Peer-Reviewed Original ResearchConceptsFluid shear stressLymphatic endothelial cellsEndothelial cellsCytoskeletal pathwaysVascular morphogenesisBiochemical signalsGene expressionEC phenotypeLymphatic fluid flowEarly eventsPhysiologyImmediate mechanismPrimary mechanismRecent advancesMorphogenesisMechanotransductionSignalingPhenotypePathwayMechanismExpressionFlow sensingCellsImportant questions
2016
Endothelial fluid shear stress sensing in vascular health and disease
Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease. Journal Of Clinical Investigation 2016, 126: 821-828. PMID: 26928035, PMCID: PMC4767335, DOI: 10.1172/jci83083.Peer-Reviewed Original ResearchConceptsNormal morphogenesisBiochemical signalsGene expressionSame pathwayFluid shear stressCell behaviorSpecialized mechanismsMorphogenesisPathwayPathological conditionsEndothelial cellsVascular physiologyVascular systemBasic mechanismsRecent advancesFlow signalingSignalingMechanismAdult lifePhysiologyExpression
2011
Dynamic molecular processes mediate cellular mechanotransduction
Hoffman BD, Grashoff C, Schwartz MA. Dynamic molecular processes mediate cellular mechanotransduction. Nature 2011, 475: 316-323. PMID: 21776077, PMCID: PMC6449687, DOI: 10.1038/nature10316.Peer-Reviewed Original ResearchConceptsCell adhesion complexesDistinct signaling pathwaysTransduction of forceDynamic molecular processesEmbryonic developmentCellular mechanotransductionPlasma membraneBiochemical signalsAdult physiologySignaling pathwaysCellular responsesSubcellular structuresMolecular processesNumerous diseasesMechanical forcesMuscular dystrophyCytoskeletonTransductionMechanotransductionPathwayPhysiologyDisassemblyRecent workMembraneAssembly
2009
Mechanotransduction in vascular physiology and atherogenesis
Hahn C, Schwartz MA. Mechanotransduction in vascular physiology and atherogenesis. Nature Reviews Molecular Cell Biology 2009, 10: 53-62. PMID: 19197332, PMCID: PMC2719300, DOI: 10.1038/nrm2596.Peer-Reviewed Original ResearchConceptsImportant regulatory factorEndothelial extracellular matrixBiochemical signalsGene expressionBlood pressureRegulatory factorsCellular responsesRegions of arteriesFluid shear stressBlood flowExtracellular matrixPhysiological responsesProgression of atherosclerosisSystemic risk factorsNormal physiological responseMechanical forcesChronic inflammationPhysiologyVascular physiologyRisk factorsHigh cholesterolVascular endotheliumAtherosclerosisBlood vesselsCells
2005
αvβ3 Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch.
Katsumi A, Matsushita T, Naoe T, Schwartz M. αvβ3 Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch. Blood 2005, 106: 3689. DOI: 10.1182/blood.v106.11.3689.3689.Peer-Reviewed Original ResearchIntegrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*
Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA. Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*. Journal Of Biological Chemistry 2005, 280: 16546-16549. PMID: 15760908, DOI: 10.1074/jbc.c400455200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEnzyme ActivationEnzyme InhibitorsExtracellular MatrixExtracellular Signal-Regulated MAP KinasesIntegrin alphaVbeta3IntegrinsJNK Mitogen-Activated Protein KinasesLigandsMAP Kinase Kinase 4MiceMitogen-Activated Protein Kinase KinasesNIH 3T3 CellsPhosphatidylinositol 3-KinasesPhosphorylationProtein ConformationSignal TransductionStress, MechanicalTime FactorsConceptsIntegrin activationExtracellular matrix proteinsRole of integrinsConformational activationBiochemical signalsNIH3T3 cellsMolecular mechanismsCellular responsesMatrix proteinsExtracellular matrixCell growthMechanical stretch stimulationIntegrin alphavbeta3IntegrinsMechanical tensionMechanical stretchCritical determinantStretch stimulationActivationPhosphoinositolMechanotransductionJNKProteinApoptosisDifferentiation
2002
Effects of cell tension on the small GTPase Rac
Katsumi A, Milanini J, Kiosses WB, del Pozo MA, Kaunas R, Chien S, Hahn KM, Schwartz MA. Effects of cell tension on the small GTPase Rac. Journal Of Cell Biology 2002, 158: 153-164. PMID: 12105187, PMCID: PMC2173027, DOI: 10.1083/jcb.200201105.Peer-Reviewed Original ResearchMeSH KeywordsAmidesAnimalsAzepinesCell LineCell MembraneCell MovementCollagenDose-Response Relationship, DrugEnergy TransferGTP PhosphohydrolasesGuanine Nucleotide Exchange FactorsMicroscopy, FluorescenceMicroscopy, Phase-ContrastMicroscopy, VideoNaphthalenesNeoplasm ProteinsProteinsPseudopodiaPyridinesRac GTP-Binding ProteinsRatsStress, MechanicalTime FactorsT-Lymphoma Invasion and Metastasis-inducing Protein 1Transfection
2001
Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration
Calderwood D, Huttenlocher A, Kiosses W, Rose D, Woodside D, Schwartz M, Ginsberg M. Increased filamin binding to β-integrin cytoplasmic domains inhibits cell migration. Nature Cell Biology 2001, 3: 1060-1068. PMID: 11781567, DOI: 10.1038/ncb1201-1060.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBinding SitesCell MovementCell PolarityCHO CellsContractile ProteinsCricetinaeCytoplasmCytoskeletonFibronectinsFilaminsFocal AdhesionsHumansIntegrin beta ChainsIntegrinsIsoleucineJurkat CellsMicrofilament ProteinsProtein Structure, TertiaryRecombinant Fusion ProteinsTalinValineConceptsFocal adhesion formationFilamin bindingCell migrationMembrane protrusionsMatrix assemblyIntegrin-dependent cell migrationFibronectin matrix assemblyAmino acid substitutionsInhibits cell migrationAnimal developmentActin cytoskeletonIntegrin tailsBiochemical signalsAdhesion receptorsFilaminCell polarizationTalinAcid substitutionsExtracellular matrixAdhesion formationTailBindingAssemblyMigrationSelective loss