2021
Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma
Gao Y, Wang M, Guo X, Hu J, Chen TM, Finn S, Lacy J, Kunstman JW, H. C, Bellin MD, Robert ME, Desir GV, Gorelick FS. Renalase is a novel tissue and serological biomarker in pancreatic ductal adenocarcinoma. PLOS ONE 2021, 16: e0250539. PMID: 34587190, PMCID: PMC8480607, DOI: 10.1371/journal.pone.0250539.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Pancreatic DuctalCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedMonoamine OxidaseNeoplasm GradingPancreatic NeoplasmsPrognosisProspective StudiesRetrospective StudiesSurvival AnalysisUp-RegulationYoung AdultConceptsPlasma renalase levelsBorderline resectable PDACRenalase levelsPDAC precursor lesionsOverall survivalPDAC tissuesTumor characteristicsResectable PDACChronic pancreatitisPrecursor lesionsNormal pancreasPancreatic ductal adenocarcinoma growthAdvanced tumor characteristicsVaried clinical stagesWorse tumor characteristicsNode-positive diseasePancreatic ductal adenocarcinomaNormal pancreatic headSpindle-shaped cellsPlasma renalaseRenalase expressionUnderwent resectionAbdominal traumaPancreatic headPositive disease
2020
Frontiers in Celiac Disease
Patel N, Robert ME. Frontiers in Celiac Disease. The American Journal Of Surgical Pathology 2020, 46: e43-e54. PMID: 33739793, DOI: 10.1097/pas.0000000000001639.Peer-Reviewed Original ResearchConceptsCeliac diseaseType II refractory celiac diseaseMonoclonal T-cell populationChildhood viral infectionsDuodenal mucosal histologyImportant autoimmune diseasesRefractory celiac diseaseCommon autoimmune disorderT cell populationsCeliac disease patientsCeliac disease pathogenesisEvaluation of responseCeliac disease manifestationsGluten toleranceDietary glutenGluten exposureMechanisms of diseaseAutoimmune conditionsHLA-DQ2Mucosal histologySymptomatic diseaseInflammatory cascadeInitial diagnosisPatient's symptomsAutoimmune disordersSmooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases
Alpert L, Al-Sabti R, Graham RP, Pai RK, Gonzalez RS, Zhang X, Smith V, Wang HL, Westbrook L, Goldblum JR, Bakhshwin A, Shetty S, Klimstra DS, Shia J, Askan G, Robert ME, Thomas C, Frankel WL, Alsomali M, Hagen C, Mostafa ME, Feely MM, Assarzadegan N, Misdraji J, Shih AR, Agostini-Vulaj D, Meis JM, Tang S, Chatterjee D, Kang LI, Hart J, Lee SM, Smith T, Yantiss RK, Hissong EM, Gao ZH, Wu J, Resnick MB, Wu EY, Pai RK, Zhao L, Doyle LA, Chopra S, Panarelli NC, Hu S, Longacre TA, Raghavan SS, Lauwers GY, Ghayouri M, Cooper HS, Nagarathinam R, Bellizzi AM, Kakar S, Hosseini M, Rong J, Greenson JK, Lamps LW, Dong Z, Bronner MP. Smooth muscle tumors of the gastrointestinal tract: an analysis of prognostic features in 407 cases. Modern Pathology 2020, 33: 1410-1419. PMID: 32051556, PMCID: PMC8405135, DOI: 10.1038/s41379-020-0492-5.Peer-Reviewed Original ResearchConceptsSmooth muscle tumorsGastrointestinal smooth muscle tumorsMuscle tumorsPrognostic featuresSmall bowelGastrointestinal tractNon-progressive tumorsProgression-free survivalSlight female predominanceDisease-related deathKaplan-Meier plotsReceiver operator characteristic analysisSoft tissue pathologistsPotential prognostic featuresOperator characteristic analysisMucosal ulcerationSerosal involvementFemale predominanceLocal recurrenceMargin statusPathologic featuresTumor sizeLarge tumorsEsophageal tumorsTumor necrosis
2018
Hepatocellular Carcinoma Outcome is Predicted by Expression of Neuronal Calcium Sensor 1
Schuette D, Moore LM, Robert ME, Taddei TH, Ehrlich BE. Hepatocellular Carcinoma Outcome is Predicted by Expression of Neuronal Calcium Sensor 1. Cancer Epidemiology Biomarkers & Prevention 2018, 27: cebp.0167.2018. PMID: 29789326, PMCID: PMC8465775, DOI: 10.1158/1055-9965.epi-18-0167.Peer-Reviewed Original ResearchConceptsNeuronal calcium sensor-1Hepatocellular carcinomaDisease outcomePrognostic biomarkerIncidence of HCCWorse disease outcomesCancer-related deathLiver cancer cohortExpression levelsFurther functional assessmentEarly tumor detectionProspective cohortAsian patientsPatient survivalVariety of Ca2Tumor microarrayHCC patientsMetastatic cancerBreast cancerCancer cohortAggressive phenotypeNovel biomarkersFunctional assessmentPredictive valueTumor progression
2017
ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation
Rostami K, Marsh M, Johnson M, Mohaghegh H, Heal C, Holmes G, Ensari A, Aldulaimi D, Bancel B, Bassotti G, Bateman A, Becheanu G, Bozzola A, Carroccio A, Catassi C, Ciacci C, Ciobanu A, Danciu M, Derakhshan M, Elli L, Ferrero S, Fiorentino M, Fiorino M, Ganji A, Ghaffarzadehgan K, Going J, Ishaq S, Mandolesi A, Mathews S, Maxim R, Mulder C, Neefjes-Borst A, Robert M, Russo I, Rostami-Nejad M, Sidoni A, Sotoudeh M, Villanacci V, Volta U, Zali M, Srivastava A. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation. Gut 2017, 66: 2080. PMID: 28893865, PMCID: PMC5749338, DOI: 10.1136/gutjnl-2017-314297.Peer-Reviewed Original ResearchConceptsIntraepithelial lymphocyte countsReceiver operating characteristicIntraepithelial lymphocytesCoeliac diseaseMarsh III lesionsIII lesionsHistological diagnosis of coeliac diseaseNormal controlsReceiver operating characteristic curve analysisDiagnosis of coeliac diseaseOptimal cut-off pointReceiver operating characteristic analysisOptimal cut-offCount intraepithelial lymphocytesCut-off pointCut-offHistological diagnosisLymphocyte countMulticentre studyDuodenal biopsiesAntigenic influenceCurve analysisBiopsyDose responseControl group
2015
American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions
Allen J, Katzka D, Robert M, Leontiadis G. American Gastroenterological Association Institute Technical Review on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions. Gastroenterology 2015, 149: 1088-1118. PMID: 26278504, DOI: 10.1053/j.gastro.2015.07.040.Peer-Reviewed Original Research
1994
Pathology of the lymph nodes in patients with malignant melanoma.
Cochran A, Robert M, Wen D. Pathology of the lymph nodes in patients with malignant melanoma. Pathology 1994, 2: 385-400. PMID: 9420909.Peer-Reviewed Original ResearchConceptsMalignant melanomaLymph nodesLymph node metastases of malignant melanomaMetastases of malignant melanomaRegional lymph node metastasisLymph node dissectionPathological risk factorsPoor survival rateDifficulty of diagnosisVisceral metastasesSelective lymphadenectomyNode dissectionSurvival rateRisk factorsClinical considerationsLymphMelanomaPatientsLymphadenectomyMetastasisPrognosisDissection
1993
Pathological evaluation of the regional lymph nodes in malignant melanoma.
Robert M, Wen D, Cochran A. Pathological evaluation of the regional lymph nodes in malignant melanoma. Seminars In Diagnostic Pathology 1993, 10: 102-15. PMID: 8506413.Peer-Reviewed Original ResearchConceptsLymph node metastasisNode metastasisMalignant melanomaLymph nodesDevelopment of lymph node metastasesPrognostic significance of metastasisDiagnosis of metastatic melanomaClinical stage II diseaseSurvival rateFive-year survival rateStage I melanomaDetection of micrometastasesPathological risk factorsStage II diseaseRegional lymph nodesMetastatic melanomaII diseasePrognostic significancePathological evaluationDifferential diagnosisMelanomaRisk factorsMetastasisClinical implicationsLymph
1990
Squamous cell carcinoma of the uterine cervix--a review with emphasis on prognostic factors and unusual variants.
Robert M, Fu Y. Squamous cell carcinoma of the uterine cervix--a review with emphasis on prognostic factors and unusual variants. Seminars In Diagnostic Pathology 1990, 7: 173-89. PMID: 2218146.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaPathological features of squamous cell carcinomaIncidence of squamous cell carcinomaRisk of lymph node metastasisFeatures of squamous cell carcinomaSmall cell undifferentiated carcinomaInvasive squamous cell carcinomaPathological featuresCervical conization specimensCell undifferentiated carcinomaLymph node metastasisCompleteness of excisionEarly invasive carcinomaPathologically distinct variantCell typesPrognostic pathologic findingsConization specimensUterine cervixTumor dimensionUndifferentiated carcinomaLocalized diseasePrognostic factorsInvasive carcinomaLymphatic invasion