2021
International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease
Gordon I, Bettenworth D, Bokemeyer A, Srivastava A, Rosty C, de Hertogh G, Robert M, Valasek M, Mao R, Li J, Harpaz N, Borralho P, Pai R, Odze R, Feakins R, Parker C, Guizzetti L, Nguyen T, Shackelton L, Sandborn W, Jairath V, Baker M, Bruining D, Fletcher J, Feagan B, Pai R, Rieder F. International consensus to standardise histopathological scoring for small bowel strictures in Crohn’s disease. Gut 2021, 71: 479-486. PMID: 33952604, PMCID: PMC8903083, DOI: 10.1136/gutjnl-2021-324374.Peer-Reviewed Original ResearchConceptsSmall bowel stricturesMucosal inflammatory diseasesBowel stricturesCrohn's diseaseHistopathological scoring systemScoring systemInflammatory diseasesIncreased bowel wall thicknessCrypt architectural distortionIntact surface epitheliumSurgically resected specimensPyloric gland metaplasiaSmall bowel Crohn's diseaseEffective medical therapyLos Angeles methodologyPaneth cell hyperplasiaBowel wall thicknessBasal lymphoplasmacytosisAnastomotic strictureMedical therapyStricture diseaseCell hyperplasiaClinical trial efficiencyNeutrophilic inflammationLymphoid aggregates
2020
Immune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease
Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2020, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-oa.Peer-Reviewed Original ResearchConceptsHelicobacter pylori gastritisUpper gastrointestinal tractCeliac diseasePylori gastritisCPI therapyCD8 ratioDuodenal biopsiesInflammatory changesLymphoid aggregatesGastrointestinal tractAnti-programmed death receptor-1/Anti-cytotoxic T-lymphocyteDeath receptor-1/Immune checkpoint inhibitor therapyImmune-related adverse eventsDeath ligand 1 antibodyColonic mucosal changesGastrointestinal tract inflammationLamina propria CD3Lamina propria inflammationUpper gastrointestinal biopsiesUpper gastrointestinal injuryCheckpoint inhibitor therapyH pylori gastritisCD8 T cells