2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacyFour Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC
Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.Peer-Reviewed Original Research
2016
Zika Virus: From Obscurity to Potentially Devastating International Threat
Landry ML, Ko AI, Kramer LD, Vasilakis N. Zika Virus: From Obscurity to Potentially Devastating International Threat. Clinical Chemistry 2016, 62: 1175-1180. PMID: 27551005, PMCID: PMC5444535, DOI: 10.1373/clinchem.2016.261917.Peer-Reviewed Original Research
2009
Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus
Landry ML, Ferguson D. Cytospin-Enhanced Immunofluorescence and Impact of Sample Quality on Detection of Novel Swine Origin (H1N1) Influenza Virus. Journal Of Clinical Microbiology 2009, 48: 957-959. PMID: 20042632, PMCID: PMC2832425, DOI: 10.1128/jcm.01678-09.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnimalsChildChild, PreschoolClinical Laboratory TechniquesFluorescent Antibody Technique, DirectHumansInfantInfant, NewbornInfluenza A Virus, H1N1 SubtypeInfluenza, HumanNasopharynxReverse Transcriptase Polymerase Chain ReactionSensitivity and SpecificityVirologyYoung AdultConceptsNovel swine-origin influenza virusesSwine-origin influenza virusImmunofluorescence antibody testingReal-time reverse transcriptase PCRCycle threshold valuesPCR-positive resultsPediatric patientsCDC assayAntibody testingNasopharyngeal swabsReverse transcriptase-PCRSwine influenzaInfluenza virusTranscriptase-PCRPositive samplesPatientsPositive resultsInfluenzaSwabsCytospins
2003
Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus
Habib-Bein NF, Beckwith WH, Mayo D, Landry ML. Comparison of SmartCycler Real-Time Reverse Transcription-PCR Assay in a Public Health Laboratory with Direct Immunofluorescence and Cell Culture Assays in a Medical Center for Detection of Influenza A Virus. Journal Of Clinical Microbiology 2003, 41: 3597-3601. PMID: 12904361, PMCID: PMC179819, DOI: 10.1128/jcm.41.8.3597-3601.2003.Peer-Reviewed Original ResearchConceptsVirus-positive specimensDirect immunofluorescence antibody stainingPublic health laboratoriesHealth laboratoriesRT-PCRMedical CenterRapid diagnosisYale-New Haven HospitalReal-time RT-PCRResults of cultureRhesus monkey kidney cell culturesImmunofluorescence antibody stainingReal-time reverse transcriptionInfluenza A virusesMonkey kidney cell culturesConventional RT-PCR analysisReal-time RT-PCR systemRespiratory specimensInfluenza APatient managementDirect immunofluorescenceCell culturesKidney cell culturesRapid turnaround timeA virus
1996
Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness.
Einarsson O, Geba G, Zhu Z, Landry M, Elias J. Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness. Journal Of Clinical Investigation 1996, 97: 915-924. PMID: 8613544, PMCID: PMC507136, DOI: 10.1172/jci118514.Peer-Reviewed Original ResearchConceptsRespiratory syncytial virusIL-11 productionParainfluenza virus type 3Airway hyperresponsivenessIL-11Viral upper respiratory tract infectionUpper respiratory tract infectionBALB/c miceSimplex virus type 2Viral-induced asthmaViral respiratory infectionsRespiratory tract infectionsNonspecific airway hyperresponsivenessVirus type 2Virus type 3Clinical bronchospasmAirway dysfunctionAirway physiologyTract infectionsRespiratory infectionsRespiratory virusesSyncytial virusC miceNasal aspiratesViral infection
1995
Fatal enterovirus type 71 infection
LANDRY M, FONSECA S, COHEN S, BOGUE C. Fatal enterovirus type 71 infection. The Pediatric Infectious Disease Journal 1995, 14: 1095-1100. PMID: 8745025, DOI: 10.1097/00006454-199512000-00013.Peer-Reviewed Original ResearchInterleukin‐11 in Respiratory Inflammation
EINARSSON O, GEBA GP, ZHOU Z, LANDRY ML, PANETTIERI RA, TRISTRAM D, WELLIVER R, METINKO A, ELIAS JA. Interleukin‐11 in Respiratory Inflammation. Annals Of The New York Academy Of Sciences 1995, 762: 89-101. PMID: 7668577, DOI: 10.1111/j.1749-6632.1995.tb32317.x.Peer-Reviewed Original ResearchAsthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity
Einarsson O, Geba G, Panuska J, Zhu Z, Landry M, Elias J. Asthma-Associated Viruses Specifically Induce Lung Stromal Cells to Produce Interleukin-11, a Mediator of Airways Hyperreactivity. CHEST Journal 1995, 107: 132s-133s. PMID: 7874994, DOI: 10.1378/chest.107.3_supplement.132s.Peer-Reviewed Original Research
1992
An adventitious viral contaminant in commercially supplied A549 cells: identification of infectious bovine rhinotracheitis virus and its impact on diagnosis of infection in clinical specimens
Fong CK, Landry ML. An adventitious viral contaminant in commercially supplied A549 cells: identification of infectious bovine rhinotracheitis virus and its impact on diagnosis of infection in clinical specimens. Journal Of Clinical Microbiology 1992, 30: 1611-1613. PMID: 1320632, PMCID: PMC265345, DOI: 10.1128/jcm.30.6.1611-1613.1992.Peer-Reviewed Original ResearchHerpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs
Landry M, Bull C. Herpes Simplex Types 1 and 2: Latency in the Genital Tract of Guinea Pigs. Intervirology 1992, 33: 204-210. PMID: 1326498, DOI: 10.1159/000150252.Peer-Reviewed Original ResearchRecurrent Genital Infection in the Guinea Pig: Differences between Herpes Simplex Types 1 and 2
Landry M, Myerson D, Bull C. Recurrent Genital Infection in the Guinea Pig: Differences between Herpes Simplex Types 1 and 2. Intervirology 1992, 34: 169-179. PMID: 1339184, DOI: 10.1159/000150279.Peer-Reviewed Original ResearchConceptsHSV-2 strainsHSV-2HSV-1Genital infectionRecurrence rateHSV-1 McKrae strainType 1Herpes simplex virus type 2Simplex virus type 2Recurrent genital infectionsHerpes simplex type 1Guinea pig modelHSV type 1Simplex type 1HSV-1 strainsVirus type 2Vaginal virusAcute infectionLesion recurrenceOcular infectionsMcKrae strainGenital tractNervous systemType 2Guinea pigs
1991
Advantages of multiple cell culture systems for detection of mixed-virus infections
Fong C, Landry M. Advantages of multiple cell culture systems for detection of mixed-virus infections. Journal Of Virological Methods 1991, 33: 283-289. PMID: 1783674, DOI: 10.1016/0166-0934(91)90027-w.Peer-Reviewed Original ResearchConceptsMRC-5 cellsHSV-1MRC-5CMV-positive casesA549 cellsHSV-1 isolatesCell culturesRhesus monkey kidney cell culturesMonkey kidney cell culturesHuman continuous cell lineImmunosuppressed patientsCytomegalovirus antigenFibroblast cell strainsCentrifugation cultureKidney cell culturesViral agentsSimultaneous infectionContinuous cell linesCulture systemShell vialsMore virusesAdenovirus isolatesEmbryo cell culturesCell culture systemMixed virus infectionsAntiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1
Reuveni H, Bull CO, Landry ML, Milstone LM, Schwartz PM. Antiviral Activity of 5-Iodo-2’-Deoxyuridine and Related Drugs in Human Keratinocytes Infected in vitro with Herpes simplex Virus Type 1. Skin Pharmacology And Physiology 1991, 4: 291-297. PMID: 1665069, DOI: 10.1159/000210964.Peer-Reviewed Original ResearchConceptsGuinea pig embryo cellsHerpes simplex virus type 1Simplex virus type 1Virus type 1Antiviral activityThymidine phosphorylaseHuman keratinocytesType 1Cutaneous viral infectionsTopical antiviral agentsAntiviral agentsViral infectionExperimental animalsEmbryo cellsRelated drugsIUdRInfected cellsKeratinocytesDrugsCellsActivityInfectionPhosphorylase
1990
Nucleic acid hybridization in viral diagnosis
Landry M. Nucleic acid hybridization in viral diagnosis. Clinical Biochemistry 1990, 23: 267-277. PMID: 2225455, DOI: 10.1016/0009-9120(90)80053-l.Peer-Reviewed Original Research
1989
Rapid and accurate viral diagnosis
Landry ML, Mayo DR, Hsiung GD. Rapid and accurate viral diagnosis. Pharmacology & Therapeutics 1989, 40: 287-328. PMID: 2499895, PMCID: PMC7133644, DOI: 10.1016/0163-7258(89)90098-3.Peer-Reviewed Original Research
1988
Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type
Landry M, Zibello T. Ability of Herpes Simplex Virus (HSV) Types 1 and 2 To Induce Clinical Disease and Establish Latency Following Previous Genital Infection with the Heterologous HSV Type. The Journal Of Infectious Diseases 1988, 158: 1220-1226. PMID: 2848899, DOI: 10.1093/infdis/158.6.1220.Peer-Reviewed Original ResearchConceptsHerpes simplex virus type 1Simplex virus type 1Virus type 1Clinical diseaseHSV typesSuperinfecting virusType 1Heterologous virus typesPrevious genital infectionsLevels of serumHSV antibodiesGenital infectionHSV-2Prior infectionLatent infectionHSV-1Type 2Months postinoculationGuinea pigsVirus typeInitial virusLatent virusSuperinfectionInfectionDisease
1987
Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study
Fong C, Landry M, Hsiung GD. Replication of human adenoviruses in guinea pig embryo cells: an ultrastructural study. Archives Of Virology 1987, 93: 247-260. PMID: 3827599, DOI: 10.1007/bf01310978.Peer-Reviewed Original ResearchConceptsProgeny virusAdenovirus 2Cellular changesEmbryo cellsHuman adenovirus 2Adenovirus typesHuman cellsCell typesAdenovirus 3Human adenovirusesCellsProtein crystalsElectron microscopic examinationAdenovirus 31Human adenovirus typesAdenovirus 7Virus infectivity assaysInfectivity assaysBiological propertiesUltrastructural studyVirusGuinea pig embryo cellsInfectious virusReplicationCharacteristic fibersImpact of cell culture sensitivity and virus concentration on rapid detection of herpes simplex virus by cytopathic effects and immunoperoxidase staining
Zhao LS, Landry ML, Balkovic ES, Hsiung GD. Impact of cell culture sensitivity and virus concentration on rapid detection of herpes simplex virus by cytopathic effects and immunoperoxidase staining. Journal Of Clinical Microbiology 1987, 25: 1401-1405. PMID: 3040800, PMCID: PMC269234, DOI: 10.1128/jcm.25.8.1401-1405.1987.Peer-Reviewed Original ResearchConceptsHerpes simplex virusSimplex virusCytopathic effectHerpes simplex virus (HSV) isolationMink lungVero cellsOverall isolation rateViral antigen detectionViral infectivity titerCell culturesApplication of immunoperoxidaseCommercial kitsMRC-5 cellsRapidity of detectionRabbit kidney cellsCulture sensitivityVirus isolationClinical specimensInfectious virusInfectivity titersHigh titersAntigen detectionIsolation rateImmunoperoxidaseRabbit kidneyEffect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs.
Zheng ZM, Landry ML, Mayo DR, Hsiung GD. Effect of 2'-fluoro-5-methyl-ara-uracil and cyclophosphamide on herpes simplex virus infection in guinea pigs. Acta Pharmacologica Sinica 1987, 8: 158-63. PMID: 2959004.Peer-Reviewed Original Research