2009
Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use
Le T, Chiarella J, Simen BB, Hanczaruk B, Egholm M, Landry ML, Dieckhaus K, Rosen MI, Kozal MJ. Low-Abundance HIV Drug-Resistant Viral Variants in Treatment-Experienced Persons Correlate with Historical Antiretroviral Use. PLOS ONE 2009, 4: e6079. PMID: 19562031, PMCID: PMC2698118, DOI: 10.1371/journal.pone.0006079.Peer-Reviewed Original ResearchConceptsAntiretroviral treatment historyDrug-resistant mutationsVirologic failureAntiretroviral useDrug-resistant variantsTreatment historyOverall burdenGenotypic resistanceHIV drug-resistant mutationsHIV drug-resistant variantsStanford HIV database algorithmDrug-resistant viral variantsSubsequent antiretroviral regimensTreatment-experienced patientsConventional genotypingPrior treatment historyUltra-deep pyrosequencingSanger sequencingAntiretroviral regimensMore antiretroviralsChart reviewAntiretroviral drugsUltra-deep sequencingClinical implicationsViral variants
2007
Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006
Gray GC, McCarthy T, Lebeck MG, Schnurr DP, Russell KL, Kajon AE, Landry ML, Leland DS, Storch GA, Ginocchio CC, Robinson CC, Demmler GJ, Saubolle MA, Kehl SC, Selvarangan R, Miller MB, Chappell JD, Zerr DM, Kiska DL, Halstead DC, Capuano AW, Setterquist SF, Chorazy ML, Dawson JD, Erdman DD. Genotype Prevalence and Risk Factors for Severe Clinical Adenovirus Infection, United States 2004–2006. Clinical Infectious Diseases 2007, 45: 1120-1131. PMID: 17918073, PMCID: PMC2064001, DOI: 10.1086/522188.Peer-Reviewed Original ResearchConceptsAdenovirus infectionIntensive care unit staySolid organ transplantationChronic disease conditionsAdenovirus isolatesUnited States 2004Adenovirus-positive specimensRisk factor modelingTyping methodsUnit stayRisk factorsAntigenic presentationChronic diseasesGenotype prevalenceClinical dataOrgan transplantationSevere diseaseRecent transplantationBone marrowBlinded comparisonDisease severityMilitary traineesSequence typing methodInfectionCancer diagnosis