Dissociation of electrophysiologic and pharmacologic stability during an abbreviated oral loading regimen of amiodarone
Rosenfeld L, Kennedy E, Perlmutter R, Bookbinder M, McPherson C, Batsford W. Dissociation of electrophysiologic and pharmacologic stability during an abbreviated oral loading regimen of amiodarone. American Heart Journal 1987, 114: 1367-1374. PMID: 3687689, DOI: 10.1016/0002-8703(87)90538-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmiodaroneArrhythmias, CardiacChromatography, High Pressure LiquidDrug Administration ScheduleDrug EvaluationElectrophysiologyFemaleHeart VentriclesHumansMaleMiddle AgedVentricular FibrillationConceptsVentricular tachycardiaMicrograms/Sinus node recovery timeCycle lengthLoading regimenEarly outpatient managementOral loading regimenSinus cycle lengthSinoatrial conduction timeWenckebach cycle lengthVentricular refractory periodsDesethylamiodarone levelsElectrophysiologic testingHV intervalOutpatient managementElectrophysiologic studySerum levelsInpatient therapyElectrophysiologic changesTreatment periodConduction timeHigh-pressure liquid chromatographyRefractory periodDosing phaseRegimen