2002
Mitral valve prolapse in the general population the benign nature of echocardiographic features in the Framingham Heart Study
Freed LA, Benjamin EJ, Levy D, Larson MG, Evans JC, Fuller DL, Lehman B, Levine RA. Mitral valve prolapse in the general population the benign nature of echocardiographic features in the Framingham Heart Study. Journal Of The American College Of Cardiology 2002, 40: 1298-1304. PMID: 12383578, DOI: 10.1016/s0735-1097(02)02161-7.Peer-Reviewed Original ResearchConceptsMitral valve prolapseClassic mitral valve prolapseFramingham Heart StudyMitral regurgitationHeart StudyEchocardiographic featuresValve prolapsePossible mitral valve prolapseTwo-dimensional echocardiographic criteriaReferral-based seriesSignificant mitral regurgitationGender-matched subjectsMR jet areaMR degreeEchocardiographic abnormalitiesEchocardiographic characteristicsAtrial enlargementEchocardiographic criteriaLA volumeVentricular abnormalitiesVentricular sizeClinical complicationsReferral seriesBenign profileGeneral population
1999
Prevalence and Clinical Outcome of Mitral-Valve Prolapse
Freed L, Levy D, Levine R, Larson M, Evans J, Fuller D, Lehman B, Benjamin E. Prevalence and Clinical Outcome of Mitral-Valve Prolapse. New England Journal Of Medicine 1999, 341: 1-7. PMID: 10387935, DOI: 10.1056/nejm199907013410101.Peer-Reviewed Original ResearchConceptsMitral valve prolapseTwo-dimensional echocardiographic criteriaClassic mitral valve prolapseStudy of patientsFramingham Heart StudyChest painFrequent complicationEchocardiographic criteriaElectrocardiographic abnormalitiesHeart failureUnadjusted prevalenceAdverse sequelaeClinical outcomesFifth examinationAtrial fibrillationCerebrovascular diseaseMitral regurgitationMitral leafletSex distributionGeneral populationHeart StudyProlapseOffspring CohortSuperior displacementPrevalencePrevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study)
Singh J, Evans J, Levy D, Larson M, Freed L, Fuller D, Lehman B, Benjamin E. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). The American Journal Of Cardiology 1999, 83: 897-902. PMID: 10190406, DOI: 10.1016/s0002-9149(98)01064-9.Peer-Reviewed Original ResearchConceptsBody mass indexColor Doppler echocardiographyClinical determinantsAortic regurgitationDoppler echocardiographyMass indexValvular regurgitationMultiple logistic regression analysisPopulation-based cohortPopulation-based estimatesLogistic regression analysisAnorectic drugsClinical variablesFramingham StudyHealthy menMale genderMild severityFemale genderMitralTricuspidGeneral populationRoutine examinationRegurgitationPrevalenceWomen