2020
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Yu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A. Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes. Nature Metabolism 2020, 2: 1013-1020. PMID: 32895576, PMCID: PMC7572844, DOI: 10.1038/s42255-020-0269-7.Peer-Reviewed Original ResearchConceptsIslet transplantationSubcutaneous spacePancreatic isletsNon-human primate modelSyngeneic islet transplantationType 1 diabetesTreatment of typeLack of neovascularizationPancreatic islet transplantationNew therapeutic paradigmHuman pancreatic isletsSustained normoglycaemiaGraft survivalHypoxic cell deathPrimate modelPreclinical modelsAnimal modelsTransplantationSubcutaneous transplantationTherapeutic paradigmDiabetesEuglycaemiaCell deathIsletsTransplantation methodologies
2018
Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation
Habertheuer A, Korutla L, Rostami S, Reddy S, Lal P, Naji A, Vallabhajosyula P. Donor tissue-specific exosome profiling enables noninvasive monitoring of acute rejection in mouse allogeneic heart transplantation. Journal Of Thoracic And Cardiovascular Surgery 2018, 155: 2479-2489. PMID: 29499866, DOI: 10.1016/j.jtcvs.2017.12.125.Peer-Reviewed Original ResearchConceptsEarly acute rejectionDonor heartsAcute rejectionHeart transplantationStudy armsImmunologic rejectionMaintenance armHeterotopic heart transplantation modelAllogeneic heart transplantationTime pointsHeart transplantation modelHeterotopic heart transplantationAbsence of rejectionNovel biomarker platformDevelopment of biomarkersNoninvasive monitoringTransplant heartCardiac allograftsImmunocompetent recipientsAllograft monitoringImmunodeficient recipientsRecipient circulationTransplantation modelDay 1Total plasma