2020
Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Levine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.Peer-Reviewed Original ResearchConceptsSyncytin-1Preeclampsia groupMaternal circulationExtracellular vesiclesCommon placental pathologyHigh expressionDiagnosis of preeclampsiaConditions of preeclampsiaBone alkaline phosphatasePotential physiologic roleTissue-specific biomarkersExtracellular microvesiclesPlasma extracellular vesiclesAlkaline phosphatasePreeclampsia subjectsNormal pregnancyPlacental pathologyCell extracellular vesiclesImproved biomarkersMaternal bloodPreeclampsiaPlacental syncytiotrophoblastMaternal plasmaPlacental alkaline phosphatasePhysiologic role
2019
Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium
Saha P, Sharma S, Korutla L, Datla SR, Shoja-Taheri F, Mishra R, Bigham GE, Sarkar M, Morales D, Bittle G, Gunasekaran M, Ambastha C, Arfat MY, Li D, Habertheuer A, Hu R, Platt MO, Yang P, Davis ME, Vallabhajosyula P, Kaushal S. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium. Science Translational Medicine 2019, 11 PMID: 31118291, PMCID: PMC6857931, DOI: 10.1126/scitranslmed.aau1168.Peer-Reviewed Original ResearchConceptsCardiac progenitor cellsMessenger RNACondition-specific mannerComputational pathway analysisProgenitor cellsCellular messenger RNAsCardiosphere-derived cellsProgenitor cell typesStem cell fieldCell-derived exosomesPathway analysisMicroRNA (miRNA) cargoCell typesExosomesTransplanted progenitor cellsCPC exosomesConditional activityPlasma exosomesC-kitCellsCell fieldTransplanted cardiac progenitor cellsRNAMyocardial infarction modelPathway
2000
Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway
Strayer D, Korutla L. Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway. Journal Of Cellular Physiology 2000, 184: 229-238. PMID: 10867648, DOI: 10.1002/1097-4652(200008)184:2<229::aid-jcp11>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDNA-Binding ProteinsFemaleGlycoproteinsHepatocyte Nuclear Factor 3-alphaLungNuclear ProteinsPhosphatidylinositol 3-KinasesPromoter Regions, GeneticProtein IsoformsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsReceptors, Cell SurfaceThyroid Nuclear Factor 1Transcription FactorsTranscription, GeneticConceptsSP-B promoterSP-B transcriptionPI3-kinaseHNF-3Consensus recognition elementSurfactant proteinsPI3-kinase pathwaySP-A receptorGel shift analysisCell transcriptional activityKinase localizationCellular functionsInteraction of SPTranscription factorsCell biologyNuclear localizationPlasma membraneKinase pathwayTranscriptional activityTranscriptionProteinSpCognate receptorsPromoterType II cells
1999
SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes
Korutla L, Strayer D. SP‐A as a cytokine: Surfactant protein‐A–regulated transcription of surfactant proteins and other genes. Journal Of Cellular Physiology 1999, 178: 379-386. PMID: 9989784, DOI: 10.1002/(sici)1097-4652(199903)178:3<379::aid-jcp12>3.0.co;2-c.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsCarrier ProteinsCells, CulturedFemaleGene Expression RegulationGenes, fosGenes, junMacrophages, PeritonealProteolipidsPulmonary AlveoliPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsRats, Sprague-DawleyRNA, MessengerTranscription, GeneticConceptsType II cellsSurfactant secretionProtein gene transcriptionSurfactant proteinsSurfactant gene expressionOverall transcript levelsC-fos transcriptionSP-A receptorII cellsSP-C mRNA levelsHost antimicrobial defenseSurfactant proteins SPMRNA levelsTranscript stabilityGene transcriptionSP-A effectsTranscript levelsGene expressionTranscriptionC-JunAlveolar type II cellsNew transcriptionSurfactant-associated proteinsSpProtein
1994
Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat
Korutla L, Stewart G, Lasz E, Maione T, Niewiarowski S. Evaluation of Recombinant Platelet Factor 4 and Protamine Sulfate for Heparin Neutralization: Clotting and Clearance Studies in Rat. Thrombosis And Haemostasis 1994, 71: 609-614. PMID: 8091389, DOI: 10.1055/s-0038-1642491.Peer-Reviewed Original ResearchConceptsRecombinant platelet factor 4Platelet factor 4Protamine sulfatePartial thromboplastin timeFactor 4Heparin clearanceHeparin neutralizationThromboplastin timeVitro additionClearance studiesDifferent physiological effectsAdverse effectsRatsOrgan depositionHeparinAnticoagulant activityPhysiological effectsGreater percentageLoss of radioactivityHalf lifeHeparin-agarose chromatographyInjectionMinLarge percentageRadioactivity