2012
Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis
Scofield M, Korutla L, Jackson T, Kalivas P, Mackler S. Nucleus Accumbens 1, a Pox virus and Zinc finger/Bric-a-brac Tramtrack Broad protein binds to TAR DNA-binding protein 43 and has a potential role in Amyotrophic Lateral Sclerosis. Neuroscience 2012, 227: 44-54. PMID: 23022214, PMCID: PMC3505276, DOI: 10.1016/j.neuroscience.2012.09.043.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAspartic AcidCell DeathCholine O-AcetyltransferaseCytoplasmDNA-Binding ProteinsEmbryo, MammalianGene Expression RegulationGlial Fibrillary Acidic ProteinGlutamic AcidImmunoprecipitationNeoplasm ProteinsNeuronsPhosphopyruvate HydrataseProtein BindingRatsRepressor ProteinsSpinal CordTransfectionUbiquitinationConceptsNucleus accumbens-1Amyotrophic lateral sclerosisPOZ/BTB domainUbiquitin-proteasome systemTDP-43Protein 43Lateral sclerosisBTB domainPrimary spinal cord culturesDevelopment of ALSTAR DNA-binding protein 43POZ/BTB proteinDNA-binding protein 43Extracellular glutamate levelsTDP-43 expressionFull-length TDP-43Spinal cord culturesGST pulldown assaysPost-translational modificationsUbiquitinated protein aggregatesCholinergic neuronsGlutamate toxicityCord culturesGlutamate levelsSpinal cord
2007
NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoREST
Korutla L, Degnan R, Wang P, Mackler S. NAC1, a cocaine‐regulated POZ/BTB protein interacts with CoREST. Journal Of Neurochemistry 2007, 101: 611-618. PMID: 17254023, DOI: 10.1111/j.1471-4159.2006.04387.x.Peer-Reviewed Original ResearchConceptsPOZ/BTB proteinPOZ/BTB domainBTB proteinsBTB domainProtein-protein interactionsHEK293T cellsNeuro-2a cellsT cellsTranscriptional regulatorsRepressor proteinRat brain samplesBrain samplesCoRESTCoimmunoprecipitation studiesHomodimer formationHomodimer assemblyRepressor mechanismProtein expressionProteinDirect interactionEndogenous interactionPresent studyPox virus
2003
The mouse nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by ap1
Mackler S, Homan Y, Korutla L, Conti A, Blendy J. The mouse nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by ap1. Neuroscience 2003, 121: 355-361. PMID: 14521994, DOI: 10.1016/s0306-4522(03)00376-2.Peer-Reviewed Original ResearchAnimalsBlotting, NorthernBlotting, SouthernCell DifferentiationCell Line, TumorChromosomes, Human, Pair 8Cloning, MolecularColforsinDNA ProbesDNA-Binding ProteinsDrosophilaDrosophila ProteinsExonsGene ExpressionHumansMiceMice, Inbred C57BLMutagenesisNerve Tissue ProteinsNeuroblastomaPromoter Regions, GeneticRatsRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerSequence AlignmentSequence AnalysisTranscription Factor AP-1Transcription FactorsTransfectionZinc Fingers
2000
Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway
Strayer D, Korutla L. Activation of surfactant protein‐B transcription: Signaling through the SP‐A receptor utilizing the PI3 kinase pathway. Journal Of Cellular Physiology 2000, 184: 229-238. PMID: 10867648, DOI: 10.1002/1097-4652(200008)184:2<229::aid-jcp11>3.0.co;2-x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDNA-Binding ProteinsFemaleGlycoproteinsHepatocyte Nuclear Factor 3-alphaLungNuclear ProteinsPhosphatidylinositol 3-KinasesPromoter Regions, GeneticProtein IsoformsProteolipidsPulmonary Surfactant-Associated Protein APulmonary Surfactant-Associated ProteinsPulmonary SurfactantsRatsReceptors, Cell SurfaceThyroid Nuclear Factor 1Transcription FactorsTranscription, GeneticConceptsSP-B promoterSP-B transcriptionPI3-kinaseHNF-3Consensus recognition elementSurfactant proteinsPI3-kinase pathwaySP-A receptorGel shift analysisCell transcriptional activityKinase localizationCellular functionsInteraction of SPTranscription factorsCell biologyNuclear localizationPlasma membraneKinase pathwayTranscriptional activityTranscriptionProteinSpCognate receptorsPromoterType II cells
1996
Mechanism of interferon action: in vivo activation of 91 kDa transcription factor.
Korutla L, Kumar R. Mechanism of interferon action: in vivo activation of 91 kDa transcription factor. Anticancer Research 1996, 16: 2789-95. PMID: 8917387.Peer-Reviewed Original ResearchConceptsLive human cellsHuman cellsSpecific cellular genesProtein tyrosine kinasesRegulation of expressionTreatment of cellsProtein phosphotyrosineCellular genesEarly biochemical eventsDistinct biological effectsTranscription factorsTyrosine phosphorylationTyrosine kinaseSodium orthovanadateBiochemical eventsCell growthInterferon actionBiological effectsPossible involvementCellsActivationVivo activationKinaseGenesPhosphorylation
1995
Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons
Kumar R, Korutla L. Induction of Expression of Interferon-Stimulated Gene Factor-3 (ISGF-3) Proteins by Interferons. Experimental Cell Research 1995, 216: 143-148. PMID: 7529187, DOI: 10.1006/excr.1995.1018.Peer-Reviewed Original ResearchCell NucleusCytosolDNA-Binding ProteinsGene Expression RegulationHumansInterferon Type IInterferon-gammaInterferon-Stimulated Gene Factor 3Interferon-Stimulated Gene Factor 3, gamma SubunitKineticsPhosphorylationPhosphotyrosineRecombinant ProteinsRNA, MessengerTranscription FactorsTumor Cells, CulturedTyrosine
1994
Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells.
Kumar R, Korutla L, Zhang K. Cell cycle-dependent modulation of alpha-interferon-inducible gene expression and activation of signaling components in Daudi cells. Journal Of Biological Chemistry 1994, 269: 25437-25441. PMID: 7929242, DOI: 10.1016/s0021-9258(18)47269-9.Peer-Reviewed Original ResearchMeSH Keywords2',5'-Oligoadenylate SynthetaseBase SequenceBurkitt LymphomaCell CycleDNA-Binding ProteinsEnzyme ActivationG1 PhaseGene Expression RegulationHumansInterferon-alphaJanus Kinase 1Molecular Sequence DataProteinsProtein-Tyrosine KinasesS PhaseSignal TransductionSTAT1 Transcription FactorTrans-ActivatorsTumor Cells, CulturedTYK2 KinaseConceptsTyk-2 kinaseJAK-1Synthetase proteinTyrosine phosphorylationGene expressionCell cycle-dependent modulationCell cycleCell cycle-dependent expressionCell cycle-dependent changesInducible gene expressionGene factor 3Unique expression patternCycle-dependent expressionG1/S phaseCell cycle progressionG1/SIFN-inducible gene expressionG2/M.Human Burkitt lymphoma Daudi cellsInduction of expressionG1/S blockG2/MDaudi cellsIFN-alpha-inducible genesCycle-dependent changes