2020
Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia
Levine L, Habertheuer A, Ram C, Korutla L, Schwartz N, Hu RW, Reddy S, Freas A, Zielinski PD, Harmon J, Molugu SK, Parry S, Vallabhajosyula P. Syncytiotrophoblast extracellular microvesicle profiles in maternal circulation for noninvasive diagnosis of preeclampsia. Scientific Reports 2020, 10: 6398. PMID: 32286341, PMCID: PMC7156695, DOI: 10.1038/s41598-020-62193-7.Peer-Reviewed Original ResearchConceptsSyncytin-1Preeclampsia groupMaternal circulationExtracellular vesiclesCommon placental pathologyHigh expressionDiagnosis of preeclampsiaConditions of preeclampsiaBone alkaline phosphatasePotential physiologic roleTissue-specific biomarkersExtracellular microvesiclesPlasma extracellular vesiclesAlkaline phosphatasePreeclampsia subjectsNormal pregnancyPlacental pathologyCell extracellular vesiclesImproved biomarkersMaternal bloodPreeclampsiaPlacental syncytiotrophoblastMaternal plasmaPlacental alkaline phosphatasePhysiologic role
2008
NAC1, a POZ/BTB protein that functions as a corepressor
Korutla L, Wang P, Jackson T, Mackler S. NAC1, a POZ/BTB protein that functions as a corepressor. Neurochemistry International 2008, 54: 245-252. PMID: 19121354, DOI: 10.1016/j.neuint.2008.12.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCentral Nervous SystemGenes, ReporterHumansKruppel-Like Transcription FactorsMiceNeoplasm ProteinsNerve Tissue ProteinsPromyelocytic Leukemia Zinc Finger ProteinProtein IsoformsProtein Structure, TertiaryProto-Oncogene ProteinsRecombinant Fusion ProteinsRepressor ProteinsTranscription, GeneticConceptsPOZ/BTB proteinBTB proteinsPOZ/BTB domainFusion proteinVP16 activation domainGST pulldown assaysGAL4 fusion proteinsTranscriptional repressor proteinZinc finger proteinProtein-protein interactionsB fusion proteinFinger proteinActivation domainTransient assaysNAC1 functionPulldown assaysRepressor proteinBTB domainNon-neuronal cellsTranscriptional inhibitionCorepressorNeuronal cellsProteinMature CNSSelective interaction
1996
Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 Cells
Korutla L, Kumar R. Inhibition of Vesicular Stomatitis Virus Replication by Epidermal Growth Factor in Human Epidermoid A-431 Cells. Biochemical And Biophysical Research Communications 1996, 220: 670-674. PMID: 8607823, DOI: 10.1006/bbrc.1996.0462.Peer-Reviewed Original ResearchConceptsEpidermal growth factorVesicular stomatitis virusInfectious viral particle productionAnti-EGF receptor monoclonal antibodyGrowth factorObserved antiviral effectReceptor monoclonal antibodyVesicular stomatitis virus replicationHuman epidermoid AVSV protein synthesisAntiviral effectViral particle productionAntiviral actionVSV infectionPrior treatmentViral protein synthesisVSV replicationPostinfection treatmentVirus replicationMonoclonal antibodiesInhibitory effectEarly effectsProtein synthesisSignificant inhibitionCell protection