2008
NAC1, a POZ/BTB protein that functions as a corepressor
Korutla L, Wang P, Jackson T, Mackler S. NAC1, a POZ/BTB protein that functions as a corepressor. Neurochemistry International 2008, 54: 245-252. PMID: 19121354, DOI: 10.1016/j.neuint.2008.12.008.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell LineCentral Nervous SystemGenes, ReporterHumansKruppel-Like Transcription FactorsMiceNeoplasm ProteinsNerve Tissue ProteinsPromyelocytic Leukemia Zinc Finger ProteinProtein IsoformsProtein Structure, TertiaryProto-Oncogene ProteinsRecombinant Fusion ProteinsRepressor ProteinsTranscription, GeneticConceptsPOZ/BTB proteinBTB proteinsPOZ/BTB domainFusion proteinVP16 activation domainGST pulldown assaysGAL4 fusion proteinsTranscriptional repressor proteinZinc finger proteinProtein-protein interactionsB fusion proteinFinger proteinActivation domainTransient assaysNAC1 functionPulldown assaysRepressor proteinBTB domainNon-neuronal cellsTranscriptional inhibitionCorepressorNeuronal cellsProteinMature CNSSelective interaction
2000
NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat
Mackler S, Korutla L, Cha X, Koebbe M, Fournier K, Bowers M, Kalivas P. NAC-1 Is a Brain POZ/BTB Protein That Can Prevent Cocaine-Induced Sensitization in the Rat. Journal Of Neuroscience 2000, 20: 6210-6217. PMID: 10934270, PMCID: PMC6772573, DOI: 10.1523/jneurosci.20-16-06210.2000.Peer-Reviewed Original ResearchConceptsPOZ/BTB proteinBTB proteinsTranscriptional regulatorsNAC-1POZ/BTB domainZinc finger regionTwo-hybrid studiesDNA-binding proteinsBTB domainTranscription factorsGene transcriptionFinger regionReporter geneProteinNuclei of neuronsMammalian brainTranscriptionBehavioral sensitizationPox virusRegulatorCell culturesAdministration of cocaineRat nucleus accumbensExpressionLong-term neuroadaptations