2020
Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection
Hu RW, Korutla L, Reddy S, Harmon J, Zielinski PD, Bueker A, Molina M, Romano C, Margulies K, McLean R, Lal P, Vallabhajosyula P. Circulating Donor Heart Exosome Profiling Enables Noninvasive Detection of Antibody-mediated Rejection. Transplantation Direct 2020, 6: e615. PMID: 33134491, PMCID: PMC7575166, DOI: 10.1097/txd.0000000000001057.Peer-Reviewed Original ResearchAntibody-mediated rejectionDonor exosomesEndomyocardial biopsyDonor heartsHuman leukocyte antigen (HLA) IHLA-I antibodiesRejection episodesTransplanted heartsComplement depositionI antibodiesPatientsClinical settingMRNA expressionAntigen IRejection typeTissue levelsI specificityProtein expressionTime pointsGold standardNoninvasive detectionAntibodiesTroponin proteinsBiopsyExosomes
2019
Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium
Saha P, Sharma S, Korutla L, Datla SR, Shoja-Taheri F, Mishra R, Bigham GE, Sarkar M, Morales D, Bittle G, Gunasekaran M, Ambastha C, Arfat MY, Li D, Habertheuer A, Hu R, Platt MO, Yang P, Davis ME, Vallabhajosyula P, Kaushal S. Circulating exosomes derived from transplanted progenitor cells aid the functional recovery of ischemic myocardium. Science Translational Medicine 2019, 11 PMID: 31118291, PMCID: PMC6857931, DOI: 10.1126/scitranslmed.aau1168.Peer-Reviewed Original ResearchConceptsCardiac progenitor cellsMessenger RNACondition-specific mannerComputational pathway analysisProgenitor cellsCellular messenger RNAsCardiosphere-derived cellsProgenitor cell typesStem cell fieldCell-derived exosomesPathway analysisMicroRNA (miRNA) cargoCell typesExosomesTransplanted progenitor cellsCPC exosomesConditional activityPlasma exosomesC-kitCellsCell fieldTransplanted cardiac progenitor cellsRNAMyocardial infarction modelPathway