2023
Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial
Kaushal S, Hare J, Hoffman J, Boyd R, Ramdas K, Pietris N, Kutty S, Tweddell J, Husain S, Menon S, Lambert L, Danford D, Kligerman S, Hibino N, Korutla L, Vallabhajosyula P, Campbell M, Khan A, Naioti E, Yousefi K, Mehranfard D, McClain-Moss L, Oliva A, Davis M. Intramyocardial cell-based therapy with Lomecel-B during bidirectional cavopulmonary anastomosis for hypoplastic left heart syndrome: the ELPIS phase I trial. European Heart Journal Open 2023, 3: oead002. PMID: 36950450, PMCID: PMC10026620, DOI: 10.1093/ehjopen/oead002.Peer-Reviewed Original ResearchCardiac magnetic resonance imagingGlobal longitudinal strainMedicinal signaling cellsEjection fractionRight ventricleOpen-label multicentre trialMajor adverse cardiac eventsHypoplastic left heart syndromeAdverse cardiac eventsInvestigational cell therapyBidirectional cavopulmonary anastomosisPhase I trialRV ejection fractionRisk of deathMagnetic resonance imagingPrimary endpointCardiac eventsRV functionSurgical palliationI trialMulticentre trialCavopulmonary anastomosisCell-based therapiesHeart syndromeRibonucleic acid
2021
Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine
Dash BC, Korutla L, Vallabhajosyula P, Hsia HC. Unlocking the Potential of Induced Pluripotent Stem Cells for Wound Healing: The Next Frontier of Regenerative Medicine. Advances In Wound Care 2021, 11: 622-638. PMID: 34155919, DOI: 10.1089/wound.2021.0049.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cell (iPSC) technologyTissue-engineered skin constructsSkin constructsSkin tissue engineeringStem cell technologyPluripotent stem cell (iPSC) technologyInduced pluripotent stem cellsPluripotent stem cellsCell-based therapiesRegenerative medicineTissue engineeringCell technologyCurrent advancementsTissue regenerationDisease modelingHiPSC linesEfficient manufacturing processesIPSC linesCurrent progressFunctional cellsLarge animal studiesNext generation