2020
Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes
Yu M, Agarwal D, Korutla L, May CL, Wang W, Griffith NN, Hering BJ, Kaestner KH, Velazquez OC, Markmann JF, Vallabhajosyula P, Liu C, Naji A. Islet transplantation in the subcutaneous space achieves long-term euglycaemia in preclinical models of type 1 diabetes. Nature Metabolism 2020, 2: 1013-1020. PMID: 32895576, PMCID: PMC7572844, DOI: 10.1038/s42255-020-0269-7.Peer-Reviewed Original ResearchConceptsIslet transplantationSubcutaneous spacePancreatic isletsNon-human primate modelSyngeneic islet transplantationType 1 diabetesTreatment of typeLack of neovascularizationPancreatic islet transplantationNew therapeutic paradigmHuman pancreatic isletsSustained normoglycaemiaGraft survivalHypoxic cell deathPrimate modelPreclinical modelsAnimal modelsTransplantationSubcutaneous transplantationTherapeutic paradigmDiabetesEuglycaemiaCell deathIsletsTransplantation methodologies
2013
NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease
Korutla L, Furlong H, Mackler S. NAC1, A POZ/BTB protein interacts with Parkin and may contribute to Parkinson’s disease. Neuroscience 2013, 257: 86-95. PMID: 24231739, DOI: 10.1016/j.neuroscience.2013.11.001.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAnimalsBrainCell Line, TransformedCentral Nervous SystemCysteine Proteinase InhibitorsCytoplasmDown-RegulationGlutathione TransferaseHumansImmunoprecipitationLeupeptinsMaleMiceNerve Tissue ProteinsNeuronsParkinson DiseaseProteasome Endopeptidase ComplexRepressor ProteinsUbiquitin-Protein LigasesConceptsNucleus accumbens-1Neuronal cell deathParkinson's diseaseDisease patientsParkinson's disease patientsProteasomal activityPOZ/BTB proteinCell deathNeuronal cellsDiseaseParkin levelsProtein levelsCell susceptibilityParkin proteinProteasome protein levelsPatientsProteasome activityUbiquitin-dependent proteasome degradationCell viabilityParkin degradationDeathParkinKey proteinsProteasome degradationToxicity
2003
NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells
Korutla L, Neustadter J, Fournier K, Mackler S. NAC1, a POZ/BTB protein present in the adult mammalian brain, triggers apoptosis after adenovirus-mediated overexpression in PC-12 cells. Neuroscience Research 2003, 46: 33-39. PMID: 12725910, DOI: 10.1016/s0168-0102(03)00024-5.Peer-Reviewed Original ResearchConceptsPC-12 cellsCell deathPOZ/BTB proteinPro-apoptotic protein BaxPOZ/BTBAnti-apoptotic protein Bcl-2Mammalian brainAdenoviral-mediated gene transferProtein Bcl-2BTB proteinsTranscription factorsCellular developmentGenomic DNAAdult mammalian brainNAC1 expressionProtein BaxCell survivalGene transferUpstream mediatorDown regulationNAC1 overexpressionBcl-2Examples actProteinOverexpression