2022
Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia
Farrelly L, Zheng S, Schrode N, Topol A, Bhanu N, Bastle R, Ramakrishnan A, Chan J, Cetin B, Flaherty E, Shen L, Gleason K, Tamminga C, Garcia B, Li H, Brennand K, Maze I. Chromatin profiling in human neurons reveals aberrant roles for histone acetylation and BET family proteins in schizophrenia. Nature Communications 2022, 13: 2195. PMID: 35459277, PMCID: PMC9033776, DOI: 10.1038/s41467-022-29922-0.Peer-Reviewed Original ResearchConceptsHistone posttranslational modificationsPosttranslational modificationsUnbiased proteomic approachPluripotent stem cellsPatient-derived neuronsH2A.Z acetylationChromatin profilingHyperacetylated histonesFamily proteinsProteomic approachProtein interactionsHistone acetylationTranscriptional abnormalitiesEpigenetic factorsExtraterminal (BET) proteinsSZ casesRisk variantsHuman neuronsStem cellsAberrant roleProtein inhibitionBona fideTreatment of schizophreniaPostmortem human brainCritical role
2013
Inducing Cellular Aging: Enabling Neurodegeneration-in-a-Dish
Brennand K. Inducing Cellular Aging: Enabling Neurodegeneration-in-a-Dish. Cell Stem Cell 2013, 13: 635-636. PMID: 24315433, PMCID: PMC3908665, DOI: 10.1016/j.stem.2013.11.017.Commentaries, Editorials and LettersMeSH KeywordsAgingAnimalsHumansInduced Pluripotent Stem CellsLamin Type AModels, BiologicalNuclear ProteinsProtein Precursors