Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes
Ikegame S, Hashiguchi T, Hung C, Dobrindt K, Brennand K, Takeda M, Lee B. Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes. Proceedings Of The National Academy Of Sciences Of The United States Of America 2021, 118: e2026027118. PMID: 33903248, PMCID: PMC8106313, DOI: 10.1073/pnas.2026027118.Peer-Reviewed Original ResearchConceptsF mutantsMeasles inclusion body encephalitisBSR-T7 cellsMeasles virus F proteinReceptor-binding proteinVirus F proteinGenomic contextFitness advantageWild-type MeVRegulatory domainHyperfusogenic phenotypePrimary human neuronsMutant libraryPoint mutantsMutantsFitness selectionMeV receptorsF phenotypeInclusion body encephalitisNeuropathogenic phenotypeFitness landscapeChronic latent infectionFusion geneF proteinHuman neuronsCommon Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection
Dobrindt K, Hoagland DA, Seah C, Kassim B, O'Shea CP, Murphy A, Iskhakova M, Fernando MB, Powell SK, Deans PJM, Javidfar B, Peter C, Møller R, Uhl SA, Garcia MF, Kimura M, Iwasawa K, Crary JF, Kotton DN, Takebe T, Huckins LM, tenOever BR, Akbarian S, Brennand KJ. Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports 2021, 16: 505-518. PMID: 33636110, PMCID: PMC7881728, DOI: 10.1016/j.stemcr.2021.02.010.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAdolescentAdultAnimalsCell LineChlorocebus aethiopsClustered Regularly Interspaced Short Palindromic RepeatsCOVID-19FemaleFurinGenetic Predisposition to DiseaseHost-Pathogen InteractionsHumansInduced Pluripotent Stem CellsMaleNeuronsPeptide HydrolasesPolymorphism, Single NucleotideSARS-CoV-2Vero CellsConceptsSARS-CoV-2Clinical complicationsSARS-CoV-2 infectionCommon genetic variationHigh-risk individualsHost genetic variantsSignificant interindividual variabilityNeuron infectionUnderlying comorbiditiesViral loadHealthy individualsViral infectionClinical heterogeneityVitro SusceptibilityEtiologic agentHost responseInterindividual variabilityDiscovery of drugsInfectionHost geneticsHuman induced pluripotent stem cellsSingle nucleotide polymorphismsAntibody repertoireMore diseasesComplications