2021
Chapter 30 Functional genomics of psychiatric disease risk using genome engineering
Garcia M, Powell S, LaMarca E, Fernando M, Cohen S, Fang G, Akbarian S, Brennand K. Chapter 30 Functional genomics of psychiatric disease risk using genome engineering. 2021, 711-734. DOI: 10.1016/b978-0-12-823577-5.00021-0.ChaptersRisk variantsDisease-relevant cell typesPsychiatric disease riskPluripotent stem cellsFunctional genomicsGenetic risk architectureGenome engineeringComplex geneticsCRISPR engineeringHiPSC modelsCell typesFunctional explorationStem cellsFunctional impactRisk architecturePossible new avenuesGenetic findingsGenetic screeningNew insightsNovel therapeutic approachesFundamental roleNew avenuesDisease pathophysiologyEpigenomeVariants
2011
Rapid Cellular Turnover in Adipose Tissue
Rigamonti A, Brennand K, Lau F, Cowan C. Rapid Cellular Turnover in Adipose Tissue. PLOS ONE 2011, 6: e17637. PMID: 21407813, PMCID: PMC3047582, DOI: 10.1371/journal.pone.0017637.Peer-Reviewed Original ResearchConceptsCellular turnoverAdipocyte populationsRapid cellular turnoverGreen fluorescent proteinIndependent experimental approachesIncorporation of BrdUFluorescent proteinMurine adipose tissueRapid turnoverTissue turnoverPossible new avenuesTurnoverAdipose tissueExperimental approachNew avenuesHistones