2020
Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism
Breen MS, Browne A, Hoffman GE, Stathopoulos S, Brennand K, Buxbaum JD, Drapeau E. Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism. Molecular Autism 2020, 11: 53. PMID: 32560742, PMCID: PMC7304190, DOI: 10.1186/s13229-020-00355-0.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAutistic DisorderChildChild, PreschoolChromosome DeletionChromosome DisordersChromosomes, Human, Pair 22FemaleGene Expression ProfilingGene Expression RegulationHumansInduced Pluripotent Stem CellsMaleNeural Stem CellsNeuronsReproducibility of ResultsWnt Signaling PathwayConceptsNeural progenitor cellsTranscriptional signatureGene co-expression network analysisHiPSC-NPCsCo-expression network analysisIndependent biological samplesHiPSC-derived neural cellsProgenitor cellsPostsynaptic density genesDistinct transcriptional signaturesGenetic risk lociHuman-induced pluripotent stem cellsPluripotent stem cellsPotassium channel activityProtein translationSpecific neurobiological pathwaysTranscriptional differencesEmbryonic developmentLoss of SHANK3Risk lociHiPSC neuronsMorphological phenotypesWnt pathwayGenesHiPSC clones
2011
Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines
Woods N, Parker A, Moraghebi R, Lutz M, Firth A, Brennand K, Berggren W, Raya A, Belmonte J, Gage F, Verma I. Brief Report: Efficient Generation of Hematopoietic Precursors and Progenitors from Human Pluripotent Stem Cell Lines. Stem Cells 2011, 29: 1158-1164. PMID: 21544903, PMCID: PMC3254148, DOI: 10.1002/stem.657.Peer-Reviewed Original ResearchConceptsEmbryonic stem cellsHuman embryonic stem cellsHematopoietic stem cellsHematopoietic progenitorsStem cellsDifferentiation protocolsDefinitive hematopoietic stem cellsHuman pluripotent stem cell linesGeneration of precursorsMultipotent hematopoietic progenitorsIPSC linesStem cell linesPrimitive hematopoietic cellsPluripotent stem cellsPluripotent stem cell lineExtra-cellular matrix componentsEmbryonic developmentHematopoietic progenitor cellsDifferent human embryonic stem cellHematopoietic lineagesDifferentiation culturesHematopoietic potentialCellular matrix componentsNovel factorHematopoietic cells