Kristen Olivera
Research
Publications
2020
The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2.
Collora JA, Liu R, Albrecht K, Ho YC. The single-cell landscape of immunological responses of CD4+ T cells in HIV versus severe acute respiratory syndrome coronavirus 2. Current Opinion In HIV And AIDS 2020, 16: 36-47. PMID: 33165008, PMCID: PMC8162470, DOI: 10.1097/coh.0000000000000655.Peer-Reviewed Original ResearchConceptsHIV-1 infectionSARS-CoV-2 infectionCD4 T cellsT cellsLymphoid tissueHIV-1SARS-CoV-2-specific CD4 T cellsAcute respiratory syndrome coronavirus 2 infectionHIV-1-specific CD4 T cellsSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSevere SARS-CoV-2 infectionSevere acute respiratory syndrome coronavirus 2CD4 T-cell depletionSyndrome coronavirus 2 infectionAcute respiratory syndrome coronavirus 2CD4 T-cell lossFollicular helper T cellsHIV-1-infected cellsRespiratory syndrome coronavirus 2Coronavirus 2 infectionCytokine release syndromeT cell lossT-cell depletionHIV-1 reservoirProtective antibody responsesSingle-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target
Liu R, Yeh YJ, Varabyou A, Collora JA, Sherrill-Mix S, Talbot CC, Mehta S, Albrecht K, Hao H, Zhang H, Pollack RA, Beg SA, Calvi RM, Hu J, Durand CM, Ambinder RF, Hoh R, Deeks SG, Chiarella J, Spudich S, Douek DC, Bushman FD, Pertea M, Ho YC. Single-cell transcriptional landscapes reveal HIV-1–driven aberrant host gene transcription as a potential therapeutic target. Science Translational Medicine 2020, 12 PMID: 32404504, PMCID: PMC7453882, DOI: 10.1126/scitranslmed.aaz0802.Peer-Reviewed Original ResearchConceptsHost gene transcriptionGene transcriptionLong terminal repeatHIV-1 reactivationCellular factorsIntegration sitesNonsense-mediated RNA decaySingle-cell transcriptional landscapePotential therapeutic targetSingle-cell transcriptome analysisHIV-1-host interactionsHIV-1HIV-1 promoterTherapeutic targetHIV-1 5' long terminal repeatRNA decayTranscriptional landscapeHIV-1-infected individualsHIV-1-infected cellsTranscriptome analysisAberrant transcriptionRNA transcriptionHost RNACellular survivalTranscription pathway