2022
Extensive protein dosage compensation in aneuploid human cancers
Schukken KM, Sheltzer J. Extensive protein dosage compensation in aneuploid human cancers. Genome Research 2022, 32: 1254-1270. PMID: 35701073, PMCID: PMC9341510, DOI: 10.1101/gr.276378.121.Peer-Reviewed Original ResearchConceptsDosage compensationPost-translational regulatory mechanismsProtein complex subunitsCopy numberHuman cancersCell cycle genesEffects of aneuploidyMajority of proteinsChromosome copy numberProtein expression dataKey driver genesChromosome copy number changesExpression of oncogenesCopy number changesKey cancer driversComplex subunitsCycle genesGene groupsCancer driversCancer proteomeRegulatory mechanismsTumor suppressorExpression dataDriver genesChromosome gains
2021
Aneuploidy as a promoter and suppressor of malignant growth
Vasudevan A, Schukken KM, Sausville EL, Girish V, Adebambo OA, Sheltzer JM. Aneuploidy as a promoter and suppressor of malignant growth. Nature Reviews Cancer 2021, 21: 89-103. PMID: 33432169, DOI: 10.1038/s41568-020-00321-1.Peer-Reviewed Original Research
2020
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Schukken K, Lin Y, Bakker P, Schubert M, Preuss S, Simon J, van den Bos H, Storchova Z, Colomé-Tatché M, Bastians H, Spierings D, Foijer F. Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition. Life Science Alliance 2020, 3: e201900499. PMID: 31980556, PMCID: PMC6985455, DOI: 10.26508/lsa.201900499.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAniline CompoundsBenzimidazolesChromosomal InstabilityDrug SynergismGene Knockdown TechniquesHT29 CellsHumansKineticsM Phase Cell Cycle CheckpointsMCF-7 CellsMicrotubulesNeoplasmsNitrilesPhenotypePolymerizationProtein Kinase InhibitorsQuinolinesSpindle ApparatusSrc-Family KinasesConceptsChromosomal instability phenotypeChromosomal instabilitySpindle assembly checkpointDefective spindle assembly checkpointMicrotubule polymerization ratesHallmarks of cancerSensitivity to microtubule poisonsSmall-molecule compound screeningTargeting aneuploidyCheckpoint inhibitionPolymerization rateSAC inhibitionEuploid counterpartsTreated tumorsMicrotubule dynamicsAneuploid cellsTarget cellsCancerTumorAneuploidyMicrotubule poisonsToxic to cellsCells
2017
CIN and Aneuploidy: Different Concepts, Different Consequences
Schukken K, Foijer F. CIN and Aneuploidy: Different Concepts, Different Consequences. BioEssays 2017, 40 PMID: 29160563, DOI: 10.1002/bies.201700147.Peer-Reviewed Original Research