2023
Oncogene-like addiction to aneuploidy in human cancers
Girish V, Lakhani A, Thompson S, Scaduto C, Brown L, Hagenson R, Sausville E, Mendelson B, Kandikuppa P, Lukow D, Yuan M, Stevens E, Lee S, Schukken K, Akalu S, Vasudevan A, Zou C, Salovska B, Li W, Smith J, Taylor A, Martienssen R, Liu Y, Sun R, Sheltzer J. Oncogene-like addiction to aneuploidy in human cancers. Science 2023, 381: eadg4521. PMID: 37410869, PMCID: PMC10753973, DOI: 10.1126/science.adg4521.Peer-Reviewed Original Research
2020
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Schukken K, Lin Y, Bakker P, Schubert M, Preuss S, Simon J, van den Bos H, Storchova Z, Colomé-Tatché M, Bastians H, Spierings D, Foijer F. Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition. Life Science Alliance 2020, 3: e201900499. PMID: 31980556, PMCID: PMC6985455, DOI: 10.26508/lsa.201900499.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAniline CompoundsBenzimidazolesChromosomal InstabilityDrug SynergismGene Knockdown TechniquesHT29 CellsHumansKineticsM Phase Cell Cycle CheckpointsMCF-7 CellsMicrotubulesNeoplasmsNitrilesPhenotypePolymerizationProtein Kinase InhibitorsQuinolinesSpindle ApparatusSrc-Family KinasesConceptsChromosomal instability phenotypeChromosomal instabilitySpindle assembly checkpointDefective spindle assembly checkpointMicrotubule polymerization ratesHallmarks of cancerSensitivity to microtubule poisonsSmall-molecule compound screeningTargeting aneuploidyCheckpoint inhibitionPolymerization rateSAC inhibitionEuploid counterpartsTreated tumorsMicrotubule dynamicsAneuploid cellsTarget cellsCancerTumorAneuploidyMicrotubule poisonsToxic to cellsCells