2021
Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice
Schukken K, Zhu Y, Bakker P, Koster M, Harkema L, Youssef S, de Bruin A, Foijer F. Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice. Scientific Reports 2021, 11: 68. PMID: 33420244, PMCID: PMC7794249, DOI: 10.1038/s41598-020-80169-5.Peer-Reviewed Original ResearchConceptsAdult miceChromosomal instabilitySpindle assembly checkpointSevere intestinal phenotypeSubstantial weight lossEmbryonic lethalityLow proliferation rateP53 inactivationVillous atrophyMouse modelAneuploid cellsIntestinal phenotypeTumor evolutionIntestinal epitheliaIntestinal atrophyTissue-specific fashionMiceProliferation rateWeight lossSpindle assembly checkpoint functionAtrophyEpitheliaAssembly checkpointTissueLethality
2020
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Schukken K, Lin Y, Bakker P, Schubert M, Preuss S, Simon J, van den Bos H, Storchova Z, Colomé-Tatché M, Bastians H, Spierings D, Foijer F. Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition. Life Science Alliance 2020, 3: e201900499. PMID: 31980556, PMCID: PMC6985455, DOI: 10.26508/lsa.201900499.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAniline CompoundsBenzimidazolesChromosomal InstabilityDrug SynergismGene Knockdown TechniquesHT29 CellsHumansKineticsM Phase Cell Cycle CheckpointsMCF-7 CellsMicrotubulesNeoplasmsNitrilesPhenotypePolymerizationProtein Kinase InhibitorsQuinolinesSpindle ApparatusSrc-Family KinasesConceptsChromosomal instability phenotypeChromosomal instabilitySpindle assembly checkpointDefective spindle assembly checkpointMicrotubule polymerization ratesHallmarks of cancerSensitivity to microtubule poisonsSmall-molecule compound screeningTargeting aneuploidyCheckpoint inhibitionPolymerization rateSAC inhibitionEuploid counterpartsTreated tumorsMicrotubule dynamicsAneuploid cellsTarget cellsCancerTumorAneuploidyMicrotubule poisonsToxic to cellsCells