2023
Hemorrhagic Conversion of Acute Ischemic Stroke
Zubair A, Sheth K. Hemorrhagic Conversion of Acute Ischemic Stroke. Neurotherapeutics 2023, 20: 705-711. PMID: 37085684, PMCID: PMC10275827, DOI: 10.1007/s13311-023-01377-1.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeHemorrhagic conversionIschemic strokeTreatment of patientsHemorrhagic transformationEndovascular thrombectomySerious complicationsThrombolytic therapyTreatment optionsRisk factorsLeading causePatient outcomesCurrent treatmentTimely managementStrokePatientsTreatmentThrombectomyMorbidityComplicationsReviewPathophysiologyTherapyMortalityDiagnosis
2022
Nanoparticle-based drug delivery for the treatment of traumatic brain injury
Mohammed F, Omay S, Sheth K, Zhou J. Nanoparticle-based drug delivery for the treatment of traumatic brain injury. Expert Opinion On Drug Delivery 2022, 20: 55-73. PMID: 36420918, PMCID: PMC9983310, DOI: 10.1080/17425247.2023.2152001.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryBrain injurySecondary outcomesClinical trialsPathophysiology of TBIPhase III clinical trialsPhase II clinical trialClinical management strategiesSite of injuryOff-target toxicityPharmacological treatmentBrain penetrationLow off-target toxicityExperimental animalsInjuryChronic timescalesDosage thresholdDrug deliveryTrialsDrug targetingOutcomesTreatmentDeliveryPathophysiology