2001
Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI
Hyder F, Kida I, Behar K, Kennan R, Maciejewski P, Rothman D. Quantitative functional imaging of the brain: towards mapping neuronal activity by BOLD fMRI. NMR In Biomedicine 2001, 14: 413-431. PMID: 11746934, DOI: 10.1002/nbm.733.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingNeuronal activityBOLD functional MRIFunctional MRICerebral cortexPharmacological treatmentGlutamate release inhibitorNeuronal glucose oxidationRat cerebral cortexRelease of glutamateRat forepaw stimulation modelFMRI signalsFunctional magnetic resonance imagingQuantitative magnetic resonance imagingBlood oxygenation levelBOLD fMRI studiesEnergy metabolismBOLD fMRI signalMulti-modal magnetic resonance imagingGlutamatergic neuronsRelease inhibitorChannel blockersRat brainOxygen deliveryNeurochemical basis
2000
Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study
Hyder F, Kennan R, Kida I, Mason G, Behar K, Rothman D. Dependence of Oxygen Delivery on Blood Flow in Rat Brain: A 7 Tesla Nuclear Magnetic Resonance Study. Cerebrovascular And Brain Metabolism Reviews 2000, 20: 485-498. PMID: 10724113, DOI: 10.1097/00004647-200003000-00007.Peer-Reviewed Original ResearchConceptsMagnetic resonance imagingCapillary bedOxygen deliveryML xCerebral oxygen deliveryNicotine hydrogen tartrateRespective control conditionsValues of CBFMorphine anesthesiaSensorimotor cortexForepaw stimulationSodium pentobarbitalRat brainBlood flowCMRO2Mature ratsCortical activityResonance imagingBasal conditionsPercentage changeRatsAdministrationCBF
1999
In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics
Rothman D, Sibson N, Hyder F, Shen J, Behar K, Shulman R. In vivo nuclear magnetic resonance spectroscopy studies of the relationship between the glutamate--glutamine neurotransmitter cycle and functional neuroenergetics. Philosophical Transactions Of The Royal Society B Biological Sciences 1999, 354: 1165-1177. PMID: 10466144, PMCID: PMC1692640, DOI: 10.1098/rstb.1999.0472.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsGlutamate-glutamine cycleNerve terminalsNeurotransmitter cycleGlucose metabolismBlood oxygenation level-dependent magnetic resonance imagingLevel-dependent magnetic resonance imagingBrain glucose oxidationCortical glucose metabolismMagnetic resonance spectroscopy studyCortex of ratsMagnetic resonance imagingFunctional imaging studiesSpecific neuronal activityOxidative glucose metabolismGlial cellsNeuronal activityResonance imagingImaging studiesHuman cortexBrain functionBrain activityRatsCortexGlucose oxidationGlutamate
1994
Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation
Hyder F, Behar K, Martin M, Blamire A, Shulman R. Dynamic Magnetic Resonance Imaging of the Rat Brain during Forepaw Stimulation. Cerebrovascular And Brain Metabolism Reviews 1994, 14: 649-655. PMID: 8014212, DOI: 10.1038/jcbfm.1994.81.Peer-Reviewed Original ResearchConceptsSomatosensory areaChloralose-anesthetized ratsDynamic magnetic resonance imagingMagnetic resonance imagingForelimb motorForepaw stimulationRat brainBrain mapping methodsElectrical stimulationMR signal intensityParietal cortexResonance imagingBrain tissueCoronal planeFractional signal changeStimulationSignal changesOxygenation stateSignal intensityRatsAnteriorCortexBloodBrain