2024
CYP2C gene polymorphisms in North African populations
Messaoudi M, Pakstis A, Boussetta S, Ben Ammar Elgaaied A, Kidd K, Cherni L. CYP2C gene polymorphisms in North African populations. Molecular Biology Reports 2024, 51: 1145. PMID: 39532754, DOI: 10.1007/s11033-024-10093-8.Peer-Reviewed Original ResearchConceptsNorth African populationsCYP2C genesHuman CYP2C genesSuperfamily of genesAfrican populationsRegulatory regionsIntronic SNPGenetic variationHaplotype frequenciesChromosome 10Pharmacogenetic markersFunctional consequencesGenesResponse to medical treatmentSNPsTunisian populationCYP2C9Drug metabolismForeign chemicalsCYP2C19North AfricansBackgroundCytochrome P450Clinically useful drugsGene polymorphismsPrincipal component analysisGenetic diversity of North African populations in the 17q21 genomic region
Messaoudi M, Pakstis A, Ezzaher T, Boussetta S, Ben Ammar Elgaaied A, Kidd K, Cherni L. Genetic diversity of North African populations in the 17q21 genomic region. Mammalian Genome 2024, 35: 445-460. PMID: 38965090, DOI: 10.1007/s00335-024-10051-6.Peer-Reviewed Original ResearchNorth African populationsSingle-nucleotide polymorphismsGenetic structureGenetic diversityDemographic history of human populationsHaplotype analysisAutosomal single-nucleotide polymorphismsHistory of human populationsAfrican populationsSouthwest Asian populationsComplex demographic historyHeterogeneous genetic structureNorth AfricaAutosomal markersDemographic historyGenetic flowGenomic regionsGenome ProjectGenetic compositionGenetic heterogeneityGlobal contextHistory of North AfricaMigration processNorth AfricansCultural factors
2023
Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders
Baglaenko Y, Wagner C, Bhoj V, Brodin P, Gershwin M, Graham D, Invernizzi P, Kidd K, Korsunsky I, Levy M, Mammen A, Nizet V, Ramirez-Valle F, Stites E, Williams M, Wilson M, Rose N, Ladd V, Sirota M. Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders. Cambridge Prisms Precision Medicine 2023, 1: e25. PMID: 38550937, PMCID: PMC10953750, DOI: 10.1017/pcm.2023.14.Peer-Reviewed Original ResearchAutoimmune diseasesPrecision medicinePathogenic autoantigenPatient subtypesDisease heterogeneityComplex etiologyMolecular profilingDiseaseAccount individual variabilityDisease mechanismsForeign cellsMolecular pathwaysNatural defense systemComplex disorderDisease treatmentHealthy tissueIndividual variabilityOwn cellsTreatmentMedicineTherapeuticsDefense systemCurrent understandingCellsAutoantigens
2022
A multipurpose panel of microhaplotypes for casework
Kidd K, Pakstis A, Gandotra N, Scharfe C, Podini D. A multipurpose panel of microhaplotypes for casework. Forensic Science International Genetics Supplement Series 2022, 8: 202-204. DOI: 10.1016/j.fsigss.2022.10.035.Peer-Reviewed Original ResearchMetabolic diversity in human populations and correlation with genetic and ancestral geographic distances
Peng G, Pakstis AJ, Gandotra N, Cowan TM, Zhao H, Kidd KK, Scharfe C. Metabolic diversity in human populations and correlation with genetic and ancestral geographic distances. Molecular Genetics And Metabolism 2022, 137: 292-300. PMID: 36252453, PMCID: PMC10131177, DOI: 10.1016/j.ymgme.2022.10.002.Peer-Reviewed Original ResearchState of the Art for Microhaplotypes
Kidd KK, Pakstis AJ. State of the Art for Microhaplotypes. Genes 2022, 13: 1322. PMID: 35893059, PMCID: PMC9329722, DOI: 10.3390/genes13081322.Peer-Reviewed Original ResearchAncient DNA reveals five streams of migration into Micronesia and matrilocality in early Pacific seafarers
Liu YC, Hunter-Anderson R, Cheronet O, Eakin J, Camacho F, Pietrusewsky M, Rohland N, Ioannidis A, Athens JS, Douglas MT, Ikehara-Quebral RM, Bernardos R, Culleton BJ, Mah M, Adamski N, Broomandkhoshbacht N, Callan K, Lawson AM, Mandl K, Michel M, Oppenheimer J, Stewardson K, Zalzala F, Kidd K, Kidd J, Schurr TG, Auckland K, Hill AVS, Mentzer AJ, Quinto-Cortés CD, Robson K, Kennett DJ, Patterson N, Bustamante CD, Moreno-Estrada A, Spriggs M, Vilar M, Lipson M, Pinhasi R, Reich D. Ancient DNA reveals five streams of migration into Micronesia and matrilocality in early Pacific seafarers. Science 2022, 377: 72-79. PMID: 35771911, PMCID: PMC9983687, DOI: 10.1126/science.abm6536.Peer-Reviewed Original ResearchConceptsEast Asian sourcesStreams of migrationSouthwest Pacific populationsPapuan ancestryRemote OceaniaGenome-wide dataAncient DNAModern individualsNew BritainAsian sourcesMariana ArchipelagoNew GuineansMicronesiaEast AsiansPacific populationsMale migrantsAncestryBritainMatrilocalityOceanianPolynesiansOceaniaCommunityArchipelagoSeafarersA multipurpose panel of microhaplotypes for use with STR markers in casework
Kidd KK, Pakstis AJ, Gandotra N, Scharfe C, Podini D. A multipurpose panel of microhaplotypes for use with STR markers in casework. Forensic Science International Genetics 2022, 60: 102729. PMID: 35696960, PMCID: PMC11071123, DOI: 10.1016/j.fsigen.2022.102729.Peer-Reviewed Original ResearchNorth Asian population relationships in a global context
Kidd KK, Evsanaa B, Togtokh A, Brissenden JE, Roscoe JM, Dogan M, Neophytou PI, Gurkan C, Bulbul O, Cherni L, Speed WC, Murtha M, Kidd JR, Pakstis AJ. North Asian population relationships in a global context. Scientific Reports 2022, 12: 7214. PMID: 35508562, PMCID: PMC9068624, DOI: 10.1038/s41598-022-10706-x.Peer-Reviewed Original ResearchConceptsPopulation genetic studiesPhylogenetic tree analysisAutosomal variationSex chromosomesGenetic variationMost populationsGenetic studiesExtensive variationPopulation relationshipsGenome ConsortiumK projectNorth AsiaRefinement of analysisAsian ethnic groupsGlobal contextAutosomesTree analysisChromosomesAsia populationEthnic groupsMitochondriaPopulationMicrohaplotypesSmall subsetNative AmericansA Distinctive Pattern of Diversity for the TAS2R38 Gene inNorth Africa
Mourali-Chebil S, Elkamel S, Boussetta S, Pakstis A, Kidd K, Benammar-Elgaaied A, Cherni L. A Distinctive Pattern of Diversity for the TAS2R38 Gene inNorth Africa. Human Biology 2022 DOI: 10.1353/hub.2017.0106.Peer-Reviewed Original ResearchNew Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes
Mestiri S, Boussetta S, Pakstis AJ, Kamel S, Gaaied A, Kidd KK, Cherni L. New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes. Molecular Genetics & Genomic Medicine 2022, 10: e1871. PMID: 35128830, PMCID: PMC8922960, DOI: 10.1002/mgg3.1871.Peer-Reviewed Original ResearchConceptsNorth African populationsSingle nucleotide polymorphismsGenetic diversityGenetic variabilitySignificant gene flowHuman genetic diversityLowest average heterozygosityAfrican populationsGene flowEvolutionary forcesGenetic structureAverage heterozygosityAdmixed AmericansChromosome 3NRG1 geneChromosome 8Genetic relationshipsGenesDomain 1Nucleotide polymorphismsSushi multiple domains 1CSMD1 geneHaplotypic analysisWorldwide populationNew insights
2021
The population genetics characteristics of a 90 locus panel of microhaplotypes
Pakstis AJ, Gandotra N, Speed WC, Murtha M, Scharfe C, Kidd KK. The population genetics characteristics of a 90 locus panel of microhaplotypes. Human Genetics 2021, 140: 1753-1773. PMID: 34643790, PMCID: PMC8553733, DOI: 10.1007/s00439-021-02382-0.Peer-Reviewed Original ResearchSTAT3 polymorphisms in North Africa and its implication in breast cancer
Ziadi W, Boussetta S, Elkamel S, Pakstis AJ, Kidd KK, Medimegh I, Elgaaied A, Cherni L. STAT3 polymorphisms in North Africa and its implication in breast cancer. Molecular Genetics & Genomic Medicine 2021, 9: e1744. PMID: 34251094, PMCID: PMC8404238, DOI: 10.1002/mgg3.1744.Peer-Reviewed Original ResearchConceptsNorth African populationsAfrican populationsSTAT3 regionSingle nucleotide polymorphismsRare haplotypesHsa-mirMiR databaseMajor haplotypesGenesNucleotide polymorphismsHaplotypesSNPsSTAT3Allele frequenciesRs7211777Tunisian populationPolymorphismPopulationDiversityNorth AfricaAllelesSignificant frequencyRecombinationAssaysCancerEditorial: Current and Emerging Trends in Human Identification and Molecular Anthropology
Gurkan C, Bulbul O, Kidd KK. Editorial: Current and Emerging Trends in Human Identification and Molecular Anthropology. Frontiers In Genetics 2021, 12: 708222. PMID: 34249111, PMCID: PMC8262838, DOI: 10.3389/fgene.2021.708222.Peer-Reviewed Original ResearchA Distinctive Pattern of Diversity for the TAS2R38 Gene in North Africa
Mourali-Chebil S, Elkamel S, Boussetta S, Pakstis A, Kidd K, Benammar-Elgaaied A, Cherni L. A Distinctive Pattern of Diversity for the TAS2R38 Gene in North Africa. Human Biology 2021, 93: 163-177. PMID: 37733614, DOI: 10.1353/hub.2021.0009.Peer-Reviewed Original ResearchGenetic relationships of Southwest Asian and Mediterranean populations
Kidd KK, Bulbul O, Gurkan C, Dogan M, Dogan S, Neophytou PI, Cherni L, Gurwitz D, Speed WC, Murtha M, Kidd JR, Pakstis AJ. Genetic relationships of Southwest Asian and Mediterranean populations. Forensic Science International Genetics 2021, 53: 102528. PMID: 34020230, DOI: 10.1016/j.fsigen.2021.102528.Peer-Reviewed Original ResearchGenetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region
Mestiri S, Boussetta S, Pakstis AJ, Elkamel S, Elgaaied ABA, Kidd KK, Cherni L. Genetic diversity of the North African population revealed by the typing of SNPs in the DRD2/ANKK1 genomic region. Gene 2021, 777: 145466. PMID: 33524518, DOI: 10.1016/j.gene.2021.145466.Peer-Reviewed Original ResearchMeSH KeywordsAdultAfrica, NorthernAllelesBlack PeopleEthnicityFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenomicsGenotypeGenotyping TechniquesHaplotypesHeterozygoteHuman MigrationHumansLinkage DisequilibriumMaleMiddle AgedPolymorphism, Single NucleotideProtein Serine-Threonine KinasesReceptors, Dopamine D2ConceptsNorth African populationsGenetic diversitySingle nucleotide polymorphismsGenetic structureAncestral gene poolPeculiar genetic structureLowest average heterozygosityNorth African onesAfrican populationsHigh linkage disequilibriumGenetic driftGenomic regionsAverage heterozygosityGene poolSame locusLinkage disequilibriumDisequilibrium analysisGenetic componentGenesNucleotide polymorphismsLociReceptor geneDiversityHuman populationEuropean populationsForensic Ancestry Inference: Data Requirements, Analysis Methods, and Interpretation of Results
Bulbul O, Kidd K. Forensic Ancestry Inference: Data Requirements, Analysis Methods, and Interpretation of Results. 2021, 225-240. DOI: 10.1201/9781003043027-12.Peer-Reviewed Original ResearchStandard DNA markersSingle nucleotide polymorphismsInformative single nucleotide polymorphismsAncestry informative single nucleotide polymorphismsDNA markersShort tandem repeatsTandem repeatsBiogeographic ancestryDNA profilesCrime scene DNANucleotide polymorphismsParallel sequencing technologiesAncestry informative SNPsShort tandem repeat polymorphismsDifferent populationsSequencing technologiesFuture forensic studiesMost populationsForensic geneticsAncestry assignmentTandem repeat polymorphismDNA samplesRepeatsAncestryDNA
2020
Population genetic data of 74 microhaplotypes in four major U.S. population groups
Oldoni F, Yoon L, Wootton SC, Lagacé R, Kidd KK, Podini D. Population genetic data of 74 microhaplotypes in four major U.S. population groups. Forensic Science International Genetics 2020, 49: 102398. PMID: 33045522, DOI: 10.1016/j.fsigen.2020.102398.Peer-Reviewed Original ResearchThe distinctive geographic patterns of common pigmentation variants at the OCA2 gene
Kidd KK, Pakstis AJ, Donnelly MP, Bulbul O, Cherni L, Gurkan C, Kang L, Li H, Yun L, Paschou P, Meiklejohn KA, Haigh E, Speed WC. The distinctive geographic patterns of common pigmentation variants at the OCA2 gene. Scientific Reports 2020, 10: 15433. PMID: 32963319, PMCID: PMC7508881, DOI: 10.1038/s41598-020-72262-6.Peer-Reviewed Original ResearchConceptsOculocutaneous albinism type 2Genetic variationOCA2 genePopulation genetic variationGeographic patternsNormal pigmentation variationPigmentation variationSingle nucleotide polymorphismsPositive selectionHypomorphic proteinEnhancer variantsPigmentation variantsGenesNucleotide polymorphismsDistinctive geographic patternsEye colorStrong selection effectsVariant frequencyPigmentationVariantsProteinAllelesVariationDifferent patternsPolymorphism