2014
Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors
Mishra-Gorur K, Çağlayan AO, Schaffer AE, Chabu C, Henegariu O, Vonhoff F, Akgümüş GT, Nishimura S, Han W, Tu S, Baran B, Gümüş H, Dilber C, Zaki MS, Hossni HA, Rivière JB, Kayserili H, Spencer EG, Rosti RÖ, Schroth J, Per H, Çağlar C, Çağlar Ç, Dölen D, Baranoski JF, Kumandaş S, Minja FJ, Erson-Omay EZ, Mane SM, Lifton RP, Xu T, Keshishian H, Dobyns WB, C. N, Šestan N, Louvi A, Bilgüvar K, Yasuno K, Gleeson JG, Günel M. Mutations in KATNB1 Cause Complex Cerebral Malformations by Disrupting Asymmetrically Dividing Neural Progenitors. Neuron 2014, 84: 1226-1239. PMID: 25521378, PMCID: PMC5024344, DOI: 10.1016/j.neuron.2014.12.014.Peer-Reviewed Original ResearchConceptsComplex cerebral malformationsCerebral cortical malformationsMicrotubule-severing enzyme kataninExome sequencing analysisMitotic spindle formationDrosophila optic lobeCerebral malformationsPatient-derived fibroblastsCell cycle progression delayCortical malformationsMotor neuronsComplex malformationsMicrotubule-associated proteinsCortical developmentReduced cell numberOptic lobeRegulatory subunitBrain developmentCatalytic subunitDeleterious mutationsSpindle formationSupernumerary centrosomesArborization defectsMalformationsHuman phenotypes
2008
Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury
Akdemir O, Berksoy I, Karaoğlan A, Barut Ş, Bilguvar K, Çirakoğlu B, Şahan E, Çolak A. Therapeutic efficacy of Ac-DMQD-CHO, a caspase 3 inhibitor, for rat spinal cord injury. Journal Of Clinical Neuroscience 2008, 15: 672-678. PMID: 18378144, DOI: 10.1016/j.jocn.2007.06.014.Peer-Reviewed Original ResearchConceptsSpinal cord injuryCord injuryGroup 2Therapeutic efficacyRat spinal cord injuryDiffuse hemorrhagic necrosisSpinal cord traumaGroup 3 ratsPolymorphonuclear leukocyte infiltrationCaspase-3 inhibitorCord traumaFunctional recoveryLeukocyte infiltrationLight microscopy examinationHemorrhagic necrosisNeurologic performanceFunctional outcomeSpinal cordRat modelTraumatic injuryVascular thrombiTreatment responseGroup 3InjuryThoracic region