2013
Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression
Miller-Jensen K, Skupsky R, Shah PS, Arkin AP, Schaffer DV. Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression. PLOS Computational Biology 2013, 9: e1003135. PMID: 23874178, PMCID: PMC3708878, DOI: 10.1371/journal.pcbi.1003135.Peer-Reviewed Original ResearchMeSH KeywordsHIV-1HumansIn Vitro TechniquesMutationPhenotypeSelection, GeneticSp1 Transcription FactorStochastic ProcessesTATA BoxTranscription, GeneticConceptsGenomic contextGene expressionSp1 mutationPromoter sequencesStochastic phenotypeEukaryotic gene expressionForward genetic screenBasal expressionHIV-1 gene expressionViral gene expressionCore promoter regionSingle-cell experimentsGene expression levelsGenetic screenHIV LTR promoterPhenotypic noiseAbsence of TatTranscription factorsPromoter elementsGenomic integrationPositive feedback loopGenetic elementsRelevant model systemPromoter regionGenetic selection
2009
Control of Stochastic Gene Expression by Host Factors at the HIV Promoter
Burnett JC, Miller-Jensen K, Shah PS, Arkin AP, Schaffer DV. Control of Stochastic Gene Expression by Host Factors at the HIV Promoter. PLOS Pathogens 2009, 5: e1000260. PMID: 19132086, PMCID: PMC2607019, DOI: 10.1371/journal.ppat.1000260.Peer-Reviewed Original Research