Kathryn Fontaine
she/her/hers
Research Development Technician Imaging Research CenterCards
About
Research
Publications
2025
Cranberry: Combined Rigid and Nonrigid Event-by-Event Motion Correction at Yale
Zhang J, Fontaine K, Volpi T, Zeng T, Du Y, Sun C, Lu Y, Toyonaga T, Onofrey J, Carson R. Cranberry: Combined Rigid and Nonrigid Event-by-Event Motion Correction at Yale. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-1. DOI: 10.1109/nss/mic/rtsd57106.2025.11286359.Peer-Reviewed Original ResearchMotion correctionEvent-by-event motion correctionMotion correction frameworkBrain PET systemAccurate motion correctionNon-rigid motion correctionMulti-target applicationsRobust motion correctionSpatial resolutionPET systemAxial fieldMotion fieldAFOVMotion transformationImage qualityCorrectionFieldResolutionImpact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET
Zeng T, Najmaoui Y, Zhang J, Fontaine K, Hu Y, Chemli Y, Gallezot J, Sun C, Lu Y, Fakhri G, Carson R, Marin T. Impact of Depth-of-Interaction and Spatially-Variant Point-Spread-Function Model on the Performance of Ultra-High Resolution Brain PET. 2021 IEEE Nuclear Science Symposium And Medical Imaging Conference (NSS/MIC) 2025, 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287015.Peer-Reviewed Original ResearchSpatially-varying point spread functionPoint spread functionAccurate point spread functionPSF modelConvergence behaviorImage qualityPoint spread function modelReconstruction toolboxPSF parametersHigh-activity regionsBrain-dedicated PET scannersDepth of interactionPoint-spread-function modelingField of viewSpatial resolutionHuman scansContrast recoverySpread functionPET systemPET scannerReal phantomBrain phantomMonte Carlo simulationsBrain positron emission tomographyCarlo simulationsDevelopment and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET
Lo C, Shanina E, Gravel P, Hu Y, Lucero S, Martins S, Mulnix T, Fontaine K, Nejati S, Sun X, Li H, Qi J, Cherry S, Carson R, Toyonaga T. Development and Initial Evaluation of 3D-Printed High Resolution Brain Phantom for PET. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41446501, PMCID: PMC12724537, DOI: 10.1109/trpms.2025.3638588.Peer-Reviewed Original ResearchPET systemPET system performanceBrain PET systemHigh-resolution PET systemsSpatial resolutionSuperior spatial resolutionBrain phantomPhantom typesPhantom preparationPhantomReconstruction parametersRepositioning accuracyContrast modulationHuman brain anatomyReconstructed imagesMode dataContrast ratioImage resolutionHigh-resolution 3D printingResolutionAnatomical fidelityWhite matterGray matterModeFidelityYRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER
Najmaoui Y, Fontaine K, Fontaine D, Zhang J, Zeng T, Volpi T, Chemli Y, Gallezot J, Tétrault M, Carson R, Fakhri G, Marin T. YRT-PET-NX: Development of a Plugin for an Open-Source PET Reconstruction Platform to Support the NeuroEXPLORER. 2025, 00: 1-2. DOI: 10.1109/nss/mic/rtsd57106.2025.11287275.Peer-Reviewed Original ResearchOpen-sourcePeak-to-valley ratioMini-Derenzo phantomReconstruction platformResolution PET scannerImage reconstruction toolsPacket decodingDetector geometryGPU accelerationMemory usagePET scannerPET systemAccurate system modelMotion correctionScatter estimationVendor softwareReconstruction timeImage reconstructionPluginImage qualitySoftwareHuman datasetsSystem modelManufacturing softwareNon-human primatesPET Head Motion Estimation Using Supervised Deep Learning with Attention
Cai Z, Zeng T, Zhang J, Lieffrig E, Fontaine K, You C, Revilla E, Duncan J, Xin J, Lu Y, Onofrey J. PET Head Motion Estimation Using Supervised Deep Learning with Attention. IEEE Transactions On Medical Imaging 2025, PP: 1-1. PMID: 41082441, DOI: 10.1109/tmi.2025.3620714.Peer-Reviewed Original ResearchHead motion estimationMotion estimationState-of-the-artMotion estimation methodSupervised deep learningRigid head motionMotion correctionCross-attentionDelineation of brain structuresSupervised mannerDeep learningPositron emission tomography scannerMotion correction approachPET raw dataMotion trackingMotion-free imagesDiagnosis of neurological disordersQuantification inaccuraciesRaw dataHead motionBrain positron emission tomographyEstimation methodHead movementsMotion artifactsQualitative resultsYRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography
Najmaoui Y, Chemli Y, Toussaint M, Petibon Y, Marty B, Fontaine K, Gallezot J, Razdevsek G, Orehar M, Dhaynaut M, Guehl N, Dolenec R, Pestotnik R, Johnson K, Ouyang J, Normandin M, Tetrault M, Lecomte R, Fakhri G, Marin T. YRT-PET: An Open-Source GPU-Accelerated Image Reconstruction Engine for Positron Emission Tomography. IEEE Transactions On Radiation And Plasma Medical Sciences 2025, PP: 1-1. PMID: 41424471, PMCID: PMC12714321, DOI: 10.1109/trpms.2025.3619872.Peer-Reviewed Original ResearchOpen-sourceImage reconstructionPositron emission tomography image reconstructionReconstruction algorithmAdvanced image reconstruction algorithmsOpen-source toolkitDevelopment of advanced algorithmsTime-of-flightScanner geometryNovel reconstruction algorithmImage reconstruction algorithmMotion correctionReusable codeGPU accelerationTime-of-flight informationPython bindingsPlugin systemSoftware toolkitMeaningful imagesData formatsFast implementationRigid motion correctionAdvanced algorithmsPoint spread function modelProprietary softwareCarotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling.
Volpi T, Gallezot J, Henry S, Dias M, Khattar N, Toyonaga T, Fontaine K, Mulnix T, Zhang J, Guo L, Gravel P, Radhakrishnan R, Hillmer A, Matuskey D, Carson R. Carotid Artery Image-Derived Blood Time-Activity Curves on the NeuroEXPLORER: Initial Multitracer Validation Against Arterial Sampling. Journal Of Nuclear Medicine 2025, 66: 1993-2001. PMID: 41043999, PMCID: PMC12676648, DOI: 10.2967/jnumed.125.270414.Peer-Reviewed Original ResearchConceptsArea under the curveCommon carotidTime-activity curvesLate area under the curveMethods:Carotid arteryRegions-of-interestResults:Blood samplesPartial volume effectsImage-derived input functionArterial blood samplesArterial input functionAlternative to arterial blood samplingBlood time-activity curvesPET kinetic modelingGold standardInput functionBackground activityArterial samplesCarotidBrain-dedicated PET scannersBrain PET
2024
Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants
Tausta S, Fontaine K, Hillmer A, Strobel S. Fluoride transport in Arabidopsis thaliana plants is impaired in Fluoride EXporter (FEX) mutants. Plant Molecular Biology 2024, 114: 17. PMID: 38342783, PMCID: PMC10859346, DOI: 10.1007/s11103-023-01413-w.Peer-Reviewed Original ResearchConceptsFluoride exportMutant plantsWT plantsArabidopsis thaliana plantsSingle cell eukaryotesMulticellular plantsThaliana plantsCell eukaryotesFluoride toleranceTerminal tissuesMutantsFluoride transportPlantsFloral stemsWildtypeArabidopsisEukaryotesEnvironmental toxinsStemBacteriaPositron emission tomographyPrimary locusToxin
2023
Markerless head motion tracking and event-by-event correction in brain PET
Zeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.Peer-Reviewed Original ResearchConceptsPoint source studyHead motion correctionSmaller residual displacementMotion correctionIterative closest point (ICP) registration algorithmHead motion trackingSpatial resolutionResidual displacementData-driven evaluation methodHigh spatial resolutionLow noiseMotion trackingStereovision cameraMotion tracking deviceStructured lightEvent correctionBrain positron emission tomography (PET) imagingTracking deviceReconstruction resultsHMT methodPoint cloudsNegative biasReference cloudUMTEvaluation methodDose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networks
Li A, Yang B, Naganawa M, Fontaine K, Toyonaga T, Carson R, Tang J. Dose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networks. Physics In Medicine And Biology 2023, 68: 245006. PMID: 37857316, PMCID: PMC10739622, DOI: 10.1088/1361-6560/ad0535.Peer-Reviewed Original Research
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