Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis
Chaudhary O, Trotta D, Wang K, Wang X, Chu X, Bradley C, Okulicz J, Maves RC, Kronmann K, Schofield CM, Blaylock JM, Deng Y, Schalper KA, Kaech SM, Agan B, Ganesan A, Emu B. Patients with HIV-associated cancers have evidence of increased T cell dysfunction and exhaustion prior to cancer diagnosis. Journal For ImmunoTherapy Of Cancer 2022, 10: e004564. PMID: 35470232, PMCID: PMC9039380, DOI: 10.1136/jitc-2022-004564.Peer-Reviewed Original ResearchConceptsViral suppressionTraditional risk factorsCase-control study designMarker of riskControl study designHIV infectionStudy cohortInhibitory receptorsRisk factorsCancer casesT cellsStudy designCancer diagnosisPLWHHIVCancerRiskCD4CellsPatientsTranscription factorsClinical cancer diagnosisCohortSuppressionInfectionDepressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women
Gaffey AE, Cavanagh CE, Rosman L, Wang K, Deng Y, Sims M, O’Brien E, Chamberlain AM, Mentz RJ, Glover LM, Burg MM. Depressive Symptoms and Incident Heart Failure in the Jackson Heart Study: Differential Risk Among Black Men and Women. Journal Of The American Heart Association 2022, 11: e022514. PMID: 35191315, PMCID: PMC9075063, DOI: 10.1161/jaha.121.022514.Peer-Reviewed Original ResearchConceptsIncident heart failureHigher depressive symptomsHF risk factorsHeart failureDepressive symptomsCause mortalityGreater riskLifestyle factorsRisk factorsCases of HFHistory of HFJackson Heart Study participantsSignificant depressive symptomsBaseline depressive symptomsJackson Heart StudyProportional hazards modelSex-specific associationsSex-specific managementCardiovascular outcomesUnadjusted associationsUnadjusted modelsHeart StudyHazards modelSymptomsStudy participants