2020
Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
Zhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling. JCI Insight 2020, 5: e131384. PMID: 32051336, PMCID: PMC7098785, DOI: 10.1172/jci.insight.131384.Peer-Reviewed Original ResearchConceptsEndothelial glucocorticoid receptorVascular inflammationGlucocorticoid receptorGlucocorticoid receptor regulationGlucocorticoid receptor resultsUpregulation of WntEndogenous glucocorticoidsExogenous glucocorticoidsGlucocorticoid response elementCardiovascular diseaseMouse endothelial cellsMouse modelEndothelial WNTInflammationReceptor regulationEndothelial cellsReceptors resultsNext-generation sequencingReceptor interactionReceptorsRegulation of WntWnt pathwayGlucocorticoidsRecent dataWnt
2014
Loss of the Endothelial Glucocorticoid Receptor Prevents the Therapeutic Protection Afforded by Dexamethasone after LPS
Goodwin JE, Feng Y, Velazquez H, Zhou H, Sessa WC. Loss of the Endothelial Glucocorticoid Receptor Prevents the Therapeutic Protection Afforded by Dexamethasone after LPS. PLOS ONE 2014, 9: e108126. PMID: 25299055, PMCID: PMC4191990, DOI: 10.1371/journal.pone.0108126.Peer-Reviewed Original ResearchConceptsKO miceLow-dose LPSSepsis-like syndromeAnti-inflammatory therapyInflammatory cytokines TNFKO mice showRegulation of NFNF-κB activationNitric oxide releaseTherapeutic protectionIL-6INOS productionCytokines TNFReceptor preventsIdentical doseControl animalsMice showGlucocorticoid receptorOxide releaseDexamethasoneLPSMiceProlonged activationActivationSepsis
2011
Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension
Goodwin JE, Zhang J, Gonzalez D, Albinsson S, Geller DS. Knockout of the vascular endothelial glucocorticoid receptor abrogates dexamethasone-induced hypertension. Journal Of Hypertension 2011, 29: 1347-1356. PMID: 21659825, PMCID: PMC3439131, DOI: 10.1097/hjh.0b013e328347da54.Peer-Reviewed Original ResearchConceptsEndothelial glucocorticoid receptorGlucocorticoid receptorMean blood pressure increaseKnockout animalsDexamethasone-induced hypertensionBlood pressure increaseCircadian BP rhythmForms of hypertensionEffects of glucocorticoidsNormal circadian BP rhythmPeripheral circadian clocksBaseline BPBP rhythmMmHg increaseContractile responseBP homeostasisResistance arteriolesTissue-specific knockoutFundamental physiologic processesDexamethasone treatmentHypertensionMouse modelControl animalsVascular endotheliumKnockout mice
2010
The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension
Goodwin JE, Zhang J, Velazquez H, Geller DS. The glucocorticoid receptor in the distal nephron is not necessary for the development or maintenance of dexamethasone-induced hypertension. Biochemical And Biophysical Research Communications 2010, 394: 266-271. PMID: 20188070, PMCID: PMC2946623, DOI: 10.1016/j.bbrc.2010.02.123.Peer-Reviewed Original ResearchConceptsGlucocorticoid-induced hypertensionGlucocorticoid receptorDistal nephronKnockout miceSimilar hypertensive responsesBaseline blood pressureDevelopment of hypertensionReceptor knockout miceAdministration of glucocorticoidsSimilar body weightGlucocorticoid receptor actionHypertensive responseRenal histologyBlood pressureUrinary excretionTissue-specific knockoutMineralocorticoid receptorHypertensionMouse modelLittermate controlsNephron numberSide effectsBody weightReceptor actionImportant mediator
2008
A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension
Goodwin JE, Zhang J, Geller DS. A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension. Journal Of The American Society Of Nephrology 2008, 19: 1291-1299. PMID: 18434569, PMCID: PMC2440298, DOI: 10.1681/asn.2007080911.Peer-Reviewed Original ResearchConceptsVascular smooth muscleAcute hypertensive responseHypertensive responseKO miceSmooth muscleGC receptorChronic hypertensive responseGlucocorticoid-Induced HypertensionNormal circadian variationBaseline BPTissue-specific knockoutMineralocorticoid receptorMouse modelHypertensionExcess reabsorptionCircadian variationCritical roleMiceReceptorsPromiscuous activationMuscleVivoKnockoutResponseGlucocorticoids