2011
Glucocorticoid-induced hypertension
Goodwin JE, Geller DS. Glucocorticoid-induced hypertension. Pediatric Nephrology 2011, 27: 1059-1066. PMID: 21744056, DOI: 10.1007/s00467-011-1928-4.BooksConceptsGlucocorticoid-induced hypertensionForms of hypertensionGlucocorticoid receptorRenal mineralocorticoid receptorsCommon clinical problemVascular smooth muscleBlood pressure regulationVascular endothelial cellsTissue-specific contributionsMineralocorticoid receptorTreatment strategiesClinical dataHypertensionSmooth muscleClinical problemAnimal modelsKidney tissuePressure regulationOrgan systemsWater reabsorptionEndothelial cellsExtra-vascular tissuesReceptorsPathogenesisMouse genetics
2008
A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension
Goodwin JE, Zhang J, Geller DS. A Critical Role for Vascular Smooth Muscle in Acute Glucocorticoid-Induced Hypertension. Journal Of The American Society Of Nephrology 2008, 19: 1291-1299. PMID: 18434569, PMCID: PMC2440298, DOI: 10.1681/asn.2007080911.Peer-Reviewed Original ResearchConceptsVascular smooth muscleAcute hypertensive responseHypertensive responseKO miceSmooth muscleGC receptorChronic hypertensive responseGlucocorticoid-Induced HypertensionNormal circadian variationBaseline BPTissue-specific knockoutMineralocorticoid receptorMouse modelHypertensionExcess reabsorptionCircadian variationCritical roleMiceReceptorsPromiscuous activationMuscleVivoKnockoutResponseGlucocorticoids