2020
Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
Zhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling. JCI Insight 2020, 5: e131384. PMID: 32051336, PMCID: PMC7098785, DOI: 10.1172/jci.insight.131384.Peer-Reviewed Original ResearchConceptsEndothelial glucocorticoid receptorVascular inflammationGlucocorticoid receptorGlucocorticoid receptor regulationGlucocorticoid receptor resultsUpregulation of WntEndogenous glucocorticoidsExogenous glucocorticoidsGlucocorticoid response elementCardiovascular diseaseMouse endothelial cellsMouse modelEndothelial WNTInflammationReceptor regulationEndothelial cellsReceptors resultsNext-generation sequencingReceptor interactionReceptorsRegulation of WntWnt pathwayGlucocorticoidsRecent dataWnt
2008
Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*
Zhang J, Ge R, Matte-Martone C, Goodwin J, Shlomchik WD, Mamula MJ, Kooshkabadi A, Hardy MP, Geller D. Characterization of a Novel Gain of Function Glucocorticoid Receptor Knock-in Mouse*. Journal Of Biological Chemistry 2008, 284: 6249-6259. PMID: 19017639, PMCID: PMC2649105, DOI: 10.1074/jbc.m807997200.Peer-Reviewed Original ResearchConceptsHuman glucocorticoid receptorStudies of glucocorticoidsAdrenocortical sizeGR altersEndogenous glucocorticoidsACTH levelsAdrenal axisReceptor knockImmunologic studiesWild-type GRMaintenance of homeostasisCorticosterone levelsGlucocorticoid receptorGlucocorticoidsNovel gainPhysiologic functionMicePathological processesMutant GRGC functionBasal regulationVivoGC physiologyHomologous recombinationHuman diseases