2023
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2023, 195-215. DOI: 10.1007/978-3-031-06231-5_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2022
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2022, 1-21. DOI: 10.1007/978-3-319-31420-4_41-2.BooksEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2021
Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease
Srivastava SP, Goodwin JE, Tripathi P, Kanasaki K, Koya D. Interactions among Long Non-Coding RNAs and microRNAs Influence Disease Phenotype in Diabetes and Diabetic Kidney Disease. International Journal Of Molecular Sciences 2021, 22: 6027. PMID: 34199672, PMCID: PMC8199750, DOI: 10.3390/ijms22116027.Peer-Reviewed Original ResearchConceptsDiabetic kidney diseaseKidney diseaseLarge-scale RNA sequencingGenome-wide profiling dataLong non-coding RNAsNon-coding RNAsDisease phenotypeTherapeutic targetNoncoding RNAsRNA sequencingPathogenesis of diabetesPotential therapeutic targetCrosstalk mechanismsRegulatory microRNAsCrosstalk interactionsLncRNAsMechanism of actionProfiling dataMicroRNAsAberrant expressionDiverse targetsDisease processDiabetesRNADisease
2019
The Glucocorticoid Receptor in Cardiovascular Health and Disease
Liu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorGlucocorticoid signalingCardiovascular systemNon-genomic pathwaysClinical outcomesExogenous glucocorticoidsGlucocorticoid treatmentCardiovascular healthCardiovascular diseaseNuclear receptor familyTherapeutic strategiesAnimal modelsSteroid hormone cortisolHormone cortisolPathological conditionsReceptorsDiseaseReceptor familySignalingDistinct gene networksHuman diseasesDirect effectCritical roleInflammationPrognosisRole of the glucocorticoid receptor in glomerular disease
Goodwin JE. Role of the glucocorticoid receptor in glomerular disease. American Journal Of Physiology. Renal Physiology 2019, 317: f133-f136. PMID: 31166704, PMCID: PMC6692724, DOI: 10.1152/ajprenal.00217.2019.Peer-Reviewed Original ResearchConceptsGlomerular diseasePotent anti-inflammatory agentSteroid delivery systemsAnti-inflammatory agentsSystemic steroidsBeneficial direct effectsUnfavorable riskSystemic administrationTherapeutic benefitGlucocorticoid receptorRisk assessment algorithmClinicians' effortsBenefit ratioVivo studiesGlucocorticoidsDiseasePersonalized medicineDirect effectDelivery systemGlomeruliSteroidsAdministrationPodocytesReceptors
2018
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2018, 205-219. DOI: 10.1007/978-3-319-31107-4_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2017
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2017, 1-16. DOI: 10.1007/978-3-319-31420-4_41-1.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species