2023
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2023, 195-215. DOI: 10.1007/978-3-031-06231-5_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2022
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2022, 1-21. DOI: 10.1007/978-3-319-31420-4_41-2.BooksEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsEndothelium contributesKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseCommon conditionRare diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesDiseaseRemodeling
2020
Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling
Zhou H, Mehta S, Srivastava SP, Grabinska K, Zhang X, Wong C, Hedayat A, Perrotta P, Fernández-Hernando C, Sessa WC, Goodwin JE. Endothelial cell–glucocorticoid receptor interactions and regulation of Wnt signaling. JCI Insight 2020, 5: e131384. PMID: 32051336, PMCID: PMC7098785, DOI: 10.1172/jci.insight.131384.Peer-Reviewed Original ResearchConceptsEndothelial glucocorticoid receptorVascular inflammationGlucocorticoid receptorGlucocorticoid receptor regulationGlucocorticoid receptor resultsUpregulation of WntEndogenous glucocorticoidsExogenous glucocorticoidsGlucocorticoid response elementCardiovascular diseaseMouse endothelial cellsMouse modelEndothelial WNTInflammationReceptor regulationEndothelial cellsReceptors resultsNext-generation sequencingReceptor interactionReceptorsRegulation of WntWnt pathwayGlucocorticoidsRecent dataWnt
2019
The Glucocorticoid Receptor in Cardiovascular Health and Disease
Liu B, Zhang TN, Knight JK, Goodwin JE. The Glucocorticoid Receptor in Cardiovascular Health and Disease. Cells 2019, 8: 1227. PMID: 31601045, PMCID: PMC6829609, DOI: 10.3390/cells8101227.Peer-Reviewed Original ResearchConceptsGlucocorticoid receptorGlucocorticoid signalingCardiovascular systemNon-genomic pathwaysClinical outcomesExogenous glucocorticoidsGlucocorticoid treatmentCardiovascular healthCardiovascular diseaseNuclear receptor familyTherapeutic strategiesAnimal modelsSteroid hormone cortisolHormone cortisolPathological conditionsReceptorsDiseaseReceptor familySignalingDistinct gene networksHuman diseasesDirect effectCritical roleInflammationPrognosis
2018
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2018, 205-219. DOI: 10.1007/978-3-319-31107-4_41.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species
2017
Endothelial Dysfunction and Vascular Remodeling in Hypertension
Goodwin J. Endothelial Dysfunction and Vascular Remodeling in Hypertension. 2017, 1-16. DOI: 10.1007/978-3-319-31420-4_41-1.Peer-Reviewed Original ResearchEndothelial dysfunctionVascular remodelingAcute kidney injuryChronic kidney diseaseSystemic blood pressureBlood pressure homeostasisKidney injuryBlood pressurePediatric populationResistance vesselsKidney diseaseChildhood obesityAdipokine adiponectinPressure homeostasisVasoactive compoundsCardiovascular diseaseNitric oxideDysfunctionCritical mediatorReactive oxygen speciesRemodelingHemodynamic forcesEndotheliumDiseaseOxygen species